Ischemia-modified albumin must be evaluated as an oxidative stress marker together with albumin and bilirubin in individuals with acute appendicitis

Varikasuvu, Seshadri Reddy; Perugu, I Balananda; Garg, Mohinder Kumar

doi:10.6061/clinics/2015(07)11

Cited by 8 publications

(8 citation statements)

References 14 publications

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“…However, subgroup analyses revealed significantly higher serum IMA levels in patients diagnosed with AA compared with the control group. Several previous studies support this expected finding [18][19][20][21][22]. is can be explained in terms of ischemia occurring in AA.…”

Section: Discussionsupporting

confidence: 62%

The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen

Yeniocak

Saraç

Yazıcıoğlu

et al. 2020

Emergency Medicine International

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Aim. The aim of this study was to evaluate the diagnostic value of serum ischemia-modified albumin (IMA) levels in patients presenting to the emergency department with acute abdominal pain and its use in differentiating acute surgical abdomen. Methods. This single-center prospective cross-sectional study included 334 adult patients who presented to the emergency department. These consisted of 194 patients (Group 1) with nontraumatic abdominal pain commencing in the preceding week, who were definitely diagnosed and either hospitalized in a specific department or planned for discharge, and a control group of 140 patients (Group 2). Results. The mean IMA value of the patients diagnosed with acute appendicitis was statistically significantly higher than that of the control group. The mean IMA value of the patients diagnosed with acute appendicitis, ovarian pathologies, and gastritis-peptic ulcer was statistically significantly higher than that of the nonspecific abdominal pain group. Conclusion. Serum IMA levels can be used as a diagnostic marker in patients with acute appendicitis. Furthermore, serum IMA levels in patients presenting to the emergency department with abdominal pain may be indicative of patients requiring surgery or of complicated cases, particularly in terms of acute appendicitis and ovarian pathologies.

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Section: Discussionsupporting

confidence: 62%

The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen

Yeniocak

Saraç

Yazıcıoğlu

et al. 2020

Emergency Medicine International

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“…Ischemia-modified albumin (IMA), calculated through the evaluation of the binding of cobalt to albumin, is a new biomarker for ischemia. A level of IMA is also detected in diseases related to oxidative stress, such as psoriasis, vascular injury of diabetes mellitus, multiple sclerosis, some cancers, acute appendicitis, polycystic ovary syndrome, and beta-thalassemia major (8)(9)(10)(11)(12)(13)(14). However, IMA has not yet been evaluated in AA.…”

Section: Introductionmentioning

confidence: 99%

Ischemic modified albumin as a new biomarker in predicting of oxidative stress in alopecia areata

Ataş¹,

Gönül²,

Öztürk³

et al. 2019

Turk J Med Sci

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Background and aim: The results show that oxidative stress is a pathophysiologic factor for alopecia areata (AA); however, the markers used can be confounding. Thus, we aimed to investigate the role of oxidative stress in the pathogenesis of AA through an evaluation of ischemia-modified albumin (IMA), other markers of the oxidant/antioxidant system; such as SOD, CAT, GSH-ST and MDA, and contributing clinical risk factors. Materials and Methods: The usefulness of IMA as a new marker for oxidative stress was compared with other markers, and evaluated in patients with AA. Results: The mean serum level of IMA was of higher statistical significance in AA patients than in the control group (IMA: 0.57±0.01 vs. 0.52±0.02 ΔABSU, p<0.0001). IMA (p=0.03, OR=25.8, 95% CI=1.4–482.7) was found to be an independent predictor of oxidative stress in patients with AA. Increased severity of AA was found as an independent risk factor for IMA. Conclusion: Long-lasting disease, male gender, >1 site involvement of disease and increased severity of disease were correlated with increased oxidation. Presence of AA, male gender and severe disease were determined to be independent risk factors for antioxidant and oxidant systems. IMA has great potential as a biomarker of oxidative stress in AA when compared to other studied biomarkers. Keywords: biomarkers, alopecia areata, oxidative stress, antioxidative system, ischemia-modified albumin

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“…In circumstances where OS increases, the extent of albumin structure modification also increases. Recently, IMA has been widely accepted as a marker of OS in many pathological conditions including AA (26)(27)(28). In their study, Dumlu et al (29) also observed increased IMA levels in the AG than in the CG.…”

Section: The Demographic Results Of Groupsmentioning

confidence: 87%

“…Eventually, complicated cases owing to late diagnosis (plastron or perforated appendicitis) and negative appendectomies continue to be encountered. In the literature, negative appendectomy rate was reportedly around 12.2%, and perforated appendicitis rate was 3.4% in adult patients (26,39). In a study conducted by Oyetunji et al (40) which involved 250.873 pediatric patients on whom appendectomy had been performed, it was demonstrated that negative appendectomy rate was 6.7%.…”

Section: Discussionmentioning

confidence: 99%

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

Demir¹,

Günal²,

Özmen³

et al. 2020

Turkish Journal of Pediatric Disease

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Objective: We aimed to investigate the potential of assessing thiol/disulfide homeostasis as novel oxidative stress markers to improve the challenging diagnosis of acute appendicitis in children. Material and Methods: A total of 60 pediatric patients (0-18 years) were enrolled in the study, 30 of which were in the control group and 30 in the acute appendicitis group. Native thiol, total thiol, dynamic disulfide, dynamic thiol, ischemia modified albümin, albumin, White blood cell, hemoglobin, hematocrit, and platelet counts of both groups were measured. The results of both groups were compared using the SPSS (Statistical Package for Social Sciences) version 17 (Chicago, USA) program. For all variables, p <0.05 was considered significant. Results: Total thiol (p<0.001), native thiol (p<0.001), and albümin (p<0.001) levels were significantly decreased while dynamic disulfide, dynamic thiol (p=0.003), and ischemia modified albümin (p<0.001) levels those indicating oxidant side were increased in acute appendicitis group compared to control. White blood cell counts in acute appendicitis group were higher (p<0.001), and platelet counts were lower (p=0.03) than the control group. Conclusion: In the differential diagnosis of acute appendicitis, especially in case that are difficult to diagnose, besides a physical examination, imaging, and current laboratory tests, quantification of thiol/disulfide homeostasis may be helpful in diagnosing. In addition, evaluating albumin and IMA levels may increase the specificity of the test. This test can be more helpful in cases diagnosis is difficult such as children small in their ages and mental retardation.

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Ischemia-modified albumin must be evaluated as an oxidative stress marker together with albumin and bilirubin in individuals with acute appendicitis

Cited by 8 publications

References 14 publications

The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen

The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen

Ischemic modified albumin as a new biomarker in predicting of oxidative stress in alopecia areata

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

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