Clinical correlation between N-terminal pro-b-type natriuretic peptide and angiographic coronary atherosclerosis

Ribeiro, Débora da Silva Freitas; Silva, Ricardo P.; Barboza, Daniella R.M.M.; Lima-Júnior, Roberto César Pereira; Ribeiro, Ronaldo A.

doi:10.6061/clinics/2014(06)07

Cited by 9 publications

(7 citation statements)

References 33 publications

(47 reference statements)

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“… 8 BNPs have been found to correlate with several radiologically relevant endpoints including right ventricular enlargement detected on chest computed tomography (CT) in patients with acute pulmonary embolism 9 , 10 and coronary atherosclerosis on angiography. 11 C-reactive protein (CRP) is also an important biomarker in AECOPD. In a systematic review for AECOPD biomarkers, 12 CRP was one of the most commonly studied biomarkers in AECOPD, and elevated concentrations have been found in AECOPD state compared to convalescence state.…”

Section: Introductionmentioning

confidence: 99%

Phenotyping COPD exacerbations using imaging and blood-based biomarkers

Alotaibi¹,

Chen²,

Hollander³

et al. 2018

COPD

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RationaleAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) are caused by a variety of different etiologic agents. Our aim was to phenotype COPD exacerbations using imaging (chest X-ray [CXR] and computed tomography [CT]) and to determine the possible role of the blood tests (C-reactive protein [CRP], the N-terminal prohormone brain natriuretic peptide [NT-proBNP]) as diagnostic biomarkers.Materials and methodsSubjects who were hospitalized with a primary diagnosis of AECOPD and who had had CXRs, CT scans, and blood collection for CRP and NT-proBNP were assessed in this study. Radiologist blinded to the clinical and laboratory characteristics of the subjects interpreted their CXRs and CT images. ANOVA and Spearman’s correlation were performed to test for associations between these imaging parameters and the blood-based biomarkers NT-proBNP and CRP; logistic regression models were used to assess the performance of these biomarkers in predicting the radiological parameters.ResultsA total of 309 subjects were examined for this study. Subjects had a mean age of 65.6±11.1 years, 66.7% of them were males, and 62.4% were current smokers, with a mean FEV1 54.4%±21.5% of predicted. Blood NT-proBNP concentrations were associated with cardiac enlargement (area under the curve [AUC] =0.72, P<0.001), pulmonary edema (AUC =0.63, P=0.009), and pleural effusion on CXR (AUC =0.64, P=0.01); whereas on CT images, NT-proBNP concentrations were associated with pleural effusion (AUC =0.71, P=0.002). Serum CRP concentrations, on the other hand, were associated with consolidation on CT images (AUC =0.75, P<0.001), ground glass opacities (AUC =0.64, P=0.028), and pleural effusion (AUC =0.72, P<0.001) on CT images. A serum CRP sensitivity-oriented cutoff point of 11.5 mg/L was selected for the presence of consolidation on CT images in subjects admitted as cases of AECOPD, which has a sensitivity of 91% and a specificity of 53% (P<0.001).ConclusionElevated CRP may indicate the presence of pneumonia, while elevated NT-proBNP may indicate cardiac dysfunction. These readily available blood-based biomarkers may provide more accurate phenotyping of AECOPD and enable the discovery of more precise therapies.

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Section: Introductionmentioning

confidence: 99%

Phenotyping COPD exacerbations using imaging and blood-based biomarkers

Alotaibi¹,

Chen²,

Hollander³

et al. 2018

COPD

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“…All articles included were published between 2000 and 2020, referring to studies conducted between 1993 and 2017. Most studies were conducted in Brazil [ 3 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 ]. Six studies were conducted in Argentina [ 59 60 61 62 63 64 ], four in Chile [ 65 66 67 68 ], four in Colombia [ 69 70 71 72 ], three in Uruguay [ 73 74 75 ] and two were multi-country studies conducted in Argentina, Brazil, Chile and Colombia [ 12 ] and Brazil and Suriname [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Cardioprotective Medication Use in Coronary Heart Disease Patients in South America: Systematic review and Meta-Analysis

Marzà-Florensa

Drotos

Gulayin

et al. 2022

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Background: Coronary heart disease (CHD) is the most common cause of death globally, and clinical guidelines recommend cardioprotective medications for patients with established CHD. Suboptimal use of these medications has been reported, but information from South America is scarce. Methods: We conducted a systematic review on prevalence of secondary prevention medication in South America. We pooled prevalence estimates, analysed time-trends and guideline compliance, and identified factors associated with medication use with meta-regression models. Results: 73 publications were included. Medication prevalence varied by class: beta-blockers 73.4%(95%CI 66.8%–79.1%), ACEI/ARBs 55.8%(95%CI 49.7%–61.8), antiplatelets 84.6%(95%CI 79.6%–88.5%), aspirin 85.1%(95%CI 79.7%–89.3%) and statins 78.9%(95%CI 71.2%–84.9%). The use of beta-blockers, ACEI/ARBs and statins increased since 1993. Ten publications reported low medication use and nine reported adequate use. Medication use was lower in community, public and rehabilitation settings compared to tertiary centres. Conclusion: Cardioprotective medication use has increased, but could be further improved particularly in community settings.

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“…The second cardiac marker, used in this study, was NT-pro-BNP. The peptide is released in response to tension and hypoxia of cardiomyocytes and is used as a diagnostic and prognostic indicator of chronic heart failure, the risk of fatal complications (myocardial infarction, stroke) [ 18 ], and also has an effect on the vascular wall, which allows us to estimate the risk of development of atherosclerosis and hypertension [ 9 , 11 , 19 , 27 ]. The analysis of the level of titles of NT-pro-BNP shows that the median value in the male and female populations has differences.…”

Section: Discussionmentioning

confidence: 99%

“…It evidences of permanent myocardium damage and is associated with worsening prognosis and high mortality [ 16 , 17 ]. N-terminal fragment of brain natriuretic peptide (NT-proBNP) is evaluated as a predictor of cardiac events and lethal outcomes in acute and chronic heart failure [ 18 ], and also plays a significant role in the formation of atherosclerosis [ 9 , 19 ]. Increased level of FABP-4, is associated with obesity, insulin resistance, hypertension, atherosclerosis [ 12 , 20 - 21 ].…”

Section: Methodsmentioning

confidence: 99%

Level of FABP3, FABP4, Nt-proBNP and Total Cardiovascular Risk in the Population of Central Kazakhstan

Marchenko

Nildibayeva

Sorokina

et al. 2017

Open Access Maced J Med Sci

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AIM:The study analyzed the level of cytokines playing the significant role in the diagnosis of circulatory system diseases and total cardiovascular risk.MATERIAL AND METHODS:The study involved 1,244 residents of Karaganda region. We had studied baseline participant characteristics, in addition to calculating the total cardiovascular risk and assessment of Fatty Acid Binding Proteins 3 (FABP3), Fatty Acid Binding Proteins 4 (FABP4) and N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) level.RESULTS:The results showed the combination of high cardiovascular risk (CVR) with increased titers of cardiac markers, reflecting common pathogenic mechanisms in its development, among residents of Karaganda region.CONCLUSION:The combination of high CVR with the increased titers of cardiac markers showed common pathogenic mechanisms in its development, and support the diagnostic and prognostic value of these parameters among residents of Karaganda region, and also reflects the possibility to include these cardiac markers in the program of screening survey of population for early prevention of cardiovascular disease and its complications.

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Clinical correlation between N-terminal pro-b-type natriuretic peptide and angiographic coronary atherosclerosis

Cited by 9 publications

References 33 publications

Phenotyping COPD exacerbations using imaging and blood-based biomarkers

Phenotyping COPD exacerbations using imaging and blood-based biomarkers

Prevalence of Cardioprotective Medication Use in Coronary Heart Disease Patients in South America: Systematic review and Meta-Analysis

Level of FABP3, FABP4, Nt-proBNP and Total Cardiovascular Risk in the Population of Central Kazakhstan

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