Residual C-peptide in patients with Type 1 diabetes and multiethnic backgrounds

Almeida, Mirella Hansen de; Dantas, Joana Rodrigues; Barone, Bianca; Serfaty, Fabiano Marcel; Kupfer, Rosane; Albernaz, Marta de Souza; Bencke, Maria Rocio; Zajdenverg, Lenita; Rodacki, Melanie; Oliveira, José Egídio Paulo de

doi:10.6061/clinics/2013(01)rc02

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Research in Germany and Italy also obtained similar results [31,32]. This is due to the duration of disease in this study subjects averaged still a decade so obtained low levels of C-peptide despite the increase of 25(OH)D 3 and this indicates that the progressive destruction of pancreatic β cells occur mainly in the first years of the emergence T1DM disease [38]. In addition, the onset that occurs at a young age also affects the levels of C-peptide [39].…”

Section: Subject Characteristicssupporting

confidence: 71%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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Type 1 Diabetes Mellitus (T1DM) has become a health problem in many countries. T1DM is the consequence of autoimmune destruction process of β cells. There was relationship between vitamin D deficiency with T1DM. The destruction process was caused by an imbalance of pro-inflammatory and anti-inflammatory cytokines. One of the pro-inflammatory cytokines is IL-2. C-peptide examination to see the function of beta cells due to destruction of pancreatic beta cell. Administration of vitamin D 3 supplementation still cause controversy and give varying results. This randomized clinical trial was conducted to determine the levels of 25(OH)D 3 , IL-2, and C-peptide in people with T1DM who received vitamin D 3 supplementation. The subjects were 26 children with T1DM, divided into K1 group (received vitamin D 3 supplementation) and K2 group (received placebo). The results showed higher levels of 25(OH)D 3 in the K1 group and statistically found a significant difference (p = 0.00). Higher levels of IL-2 and lower C-peptide were obtained in the K1 group and no statistically significant differences were found (p = 0.76 and p= 0.26). The insignificant relationship and the negative correlation were found between 25(OH)D 3 and IL-2 (p = 0.71; r = -0.12), 25(OH)D 3 and C-peptide (p = 0.59; r = -0.16), also levels of IL-2 and C-peptide (p = 0.13; r = -0.44) in children with type 1 diabetes who received vitamin D3 supplementation. From this study can be concluded that administration vitamin D 3 supplementation in patients with T1DM can increase levels 25(OH)D 3 significantly. This increase has not significantly lowered levels of IL-2 and increased levels of C-peptide. However, there was an absolute decrease in the rate of slower C-peptide in the supplemented group than in the placebo group.

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Section: Subject Characteristicssupporting

confidence: 71%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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“…Hal ini menunjukkan bahwa untuk mengetahui efek DM tipe 1 pada pankreas tidak dapat dilakukan dalam hitungan bulan melainkan dalam hitungan dekade atau minimal dalam lima tahun. [21][22][23] Perjalanan alamiah penyakit DM tipe 1 berhubungan dengan komplikasi jangka panjang, salah satu diantaranya adalah risiko terjadinya osteoporosis. Salah satu biomarker dari aktivitas pembentukan tulang adalah osteokalsin.…”

Section: Pembahasanunclassified

Pengaruh Pemberian Vitamin D3 Terhadap Kadar Osteokalsin, 25(oh)d Dan Durasi Sakit Pada Diabetes Mellitus Tipe 1 Pada Anak

Setia

Tjahjono

2019

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Diabetes mellitus tipe 1 (DM tipe 1) adalah salah satu penyakit kronik yang sampai saat ini belum dapat disembuhkan. Anak dan remaja dengan T1D (type 1 diabetes) mempunyai risiko osteoporosis dan komplikasi jangka panjang lainnya lebih tinggi daripada anak dan remaja nondiabetik. Kadar 25(OH)D ditemukan lebih rendah pada anak dengan DM tipe 1. Penelitian ini ingin membuktikan bahwa suplementasi vitamin D3 pada anak dengan DM tipe 1 dapat meningkatkan kadar 25(OH)D dan osteokalsin, serta ingin mengetahui hubungan antara durasi sakit terhadap kadar osteokalsin dan 25(OH)D serum. Desain penelitian ini adalah double-blinded randomized controlled trial suplementasi vitamin D3 pada anak dengan DM tipe 1. Sebanyak 26 pasien rawat jalan dengan DM tipe 1 berusia 1-18 tahun berpartisipasi dalam penelitian ini. Pasien kemudian dibagi menjadi 2 kelompok, kelompok kontrol dan kelompok perlakuan, sedangkan durasi sakit dibagi menjadi 2, yaitu kurang dan lebih dari lima tahun. Pasien diberikan vitamin D3 2000 IU tiap hari selama 6 bulan. Hasil penelitian mendapatkan bahwa kadar osteokalsin pada kelompok perlakuan lebih tiggi namun tidak berbeda bermakna dibandingkan dengan kelompok kontrol (p=0,663). Namun, kadar 25(OH)D pada kelompok perlakukan lebih tinggi secara signifikan dibanding dengan kelompok kontrol (p=0,000). Tidak ada korelasi antara durasi penyakit, baik dengan kadar osteokalsin maupun kadar 25(OH)D (p=0,955 dan p=0,203 secara berurutan). Pemberian vitamin D3 selama 6 bulan pada anak dengan DM tipe 1 dapat meningkatkan kadar osteokalsin dan 25(OH)D serum. Durasi penyakit tidak berhubungan dengan kadar osteokalsin dan 25(OH)D setelah suplementasi vitamin D3 selama 6 bulan. Kata kunci: diabetes mellitus tipe 1, durasi penyakit, osteokalsin, vitamin D3

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“…It is likely that the improved glycaemic control that is associated with residual beta-cell function (5,(7)(8)(9)(10) results in reduced vascular damage, with hyperglycaemia acknowledged as the principal cause of microvascular complications (11). However, significant reductions in HbA1c and time spent in hyperglycaemia only occur at high beta-cell function (C-peptide ~200 pmol/L) (4,9,12), while even very low levels of beta-cell function may offer protection against diabetes-related complications (C-peptide >10 pmol/L) (5,7,13). It is unclear how beta-cell function may protect against complications independently of reducing hyperglycaemic induced damage.…”

Section: Introductionmentioning

confidence: 99%

Type 1 Diabetes Patients With Different Residual Beta-Cell Function but Similar Age, HBA1c, and Cardiorespiratory Fitness Have Differing Exercise-Induced Angiogenic Cell Mobilisation

et al. 2022

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BackgroundMany individuals with type 1 diabetes retain residual beta-cell function. Sustained endogenous insulin and C-peptide secretion is associated with reduced diabetes related complications, but underlying mechanisms remain unclear. Lower circulating numbers of endothelial and hematopoietic progenitor cells (EPCs and HPCs), and the inability to increase the count of these cells in response to exercise, are also associated with increased diabetes complications and cardiovascular disease. It is unknown whether residual beta-cell function influences HPCs and EPCs. Thus, this study examined the influence of residual beta-cell function in type 1 diabetes upon exercise-induced changes in haematopoietic (HPCs) and endothelial progenitor cells (EPCs).MethodsParticipants with undetectable stimulated C-peptide (n=11; Cpepund), 10 high C-peptide (Cpephigh; >200 pmol/L), and 11 non-diabetes controls took part in this observational exercise study, completing 45 minutes of intensive walking at 60% V˙O2peak. Clinically significant HPCs (CD34+) and EPCs (CD34+VEGFR2+) phenotypes for predicting future adverse cardiovascular outcomes, and subsequent cell surface expression of chemokine receptor 4 (CXCR4) and 7 (CXCR7), were enumerated at rest and immediately post-exercise by flow cytometry.ResultsExercise increased HPCs and EPCs phenotypes similarly in the Cpephigh and control groups (+34-121% across phenotypes, p<0.04); but Cpepund group did not significantly increase from rest, even after controlling for diabetes duration. Strikingly, the post-exercise Cpepund counts were still lower than Cpephigh at rest.ConclusionsResidual beta-cell function is associated with an intact exercise-induced HPCs and EPCs mobilisation. As key characteristics (age, fitness, HbA1c) were similar between groups, the mechanisms underpinning the absent mobilisation within those with negative C-peptide, and the vascular implications, require further investigation.

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Residual C-peptide in patients with Type 1 diabetes and multiethnic backgrounds

Cited by 6 publications

References 23 publications

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Pengaruh Pemberian Vitamin D3 Terhadap Kadar Osteokalsin, 25(oh)d Dan Durasi Sakit Pada Diabetes Mellitus Tipe 1 Pada Anak

Type 1 Diabetes Patients With Different Residual Beta-Cell Function but Similar Age, HBA1c, and Cardiorespiratory Fitness Have Differing Exercise-Induced Angiogenic Cell Mobilisation

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