High Residual Platelet Activity in Response to Acetylsalicylic Acid in Acute
            Coronary Syndrome: A New Challenge for Antiplatelet Treatment?

Filho, Dário Celestino Sobral; Júnior, José Gildo de Moura Monteiro

doi:10.5935/abc.20190199

Cited by 4 publications

(3 citation statements)

References 21 publications

(34 reference statements)

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“…Glycine, serine, and threonine metabolism is impaired in vascular endothelial cells exposed to oxidized low density lipoprotein 23. The production of reactive oxygen species due to metabolic disorders of glutathione contributes to the development of atherosclerosis 24. The pathological mechanism of bile acid biosynthesis in atherosclerosis has not been reported, but high serum bilirubin levels are protective against intracranial atherosclerosis 25.…”

Section: Discussionmentioning

confidence: 99%

Thrombosis origin identification of cardioembolism and large artery atherosclerosis by distinct metabolites

Bai

Hao

et al. 2022

J NeuroIntervent Surg

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BackgroundThe diagnosis of cerebral thrombosis origin is challenging and remains unclear. This study aims to identify thrombosis due to cardioembolism (CE) and large artery atherosclerosis (LAA) from a new perspective of distinct metabolites.MethodsDistinct metabolites between 26 CE and 22 LAA origin thrombi, which were extracted after successful mechanical thrombectomy in patients with acute ischemic stroke in the anterior circulation, were analyzed with a ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) system. Enriched metabolic pathways related to the metabolites were identified. Least absolute shrinkage selection operator regression analyses and a filtering method were used to select potential predictors. Furthermore, four machine learning classifiers, including decision tree, logistic regression, random forest (RF), and k means unsupervised classification model, were used to evaluate the predictive ability of the selected metabolites.ResultsUPLC-QTOF-MS analysis revealed that levels of 88 and 55 metabolites were elevated in LAA and CE thrombi, respectively. Kyoto Encyclopedia of Genes and Genomes analysis revealed a significant difference between the pathways enriched in the two types of thrombi. Six metabolites (diglyceride (DG, 18:3/24:0), DG (22:0/24:0), phytosphingosine, galabiosylceramide (18:1/24:1), triglyceride (15:0/16:1/o–18:0), and glucosylceramide (18:1/24:0)) were finally selected to build a predictive model. The predictive RF model was confirmed to be the best, with a satisfactory stability and prediction capacity (area under the curve=0.889).ConclusionsSix metabolites as potential predictors for distinguishing between cerebral thrombi of CE and LAA origin were identified. The results are useful for understanding the pathogenesis and for secondary stroke prevention.

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Section: Discussionmentioning

confidence: 99%

Thrombosis origin identification of cardioembolism and large artery atherosclerosis by distinct metabolites

Bai

Hao

et al. 2022

J NeuroIntervent Surg

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“…(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). No two individuals' platelets are precisely the same, something that can be clearly observed in the heterogeneity of their responses to agonist and to antiplatelet agents (20)(21)(22)(23)(24), Studies using antiplatelet drugs have shown that marked differences in platelet responses may be linked to such factors, with genomic and nutrigenomic reasons postulated (25,26). The approach to antiplatelet medication in secondary prevention has begun to evolve, as it becomes clearer that different demographics may respond very differently to xed doses of antiplatelets (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Equivalence of Different Intakes of Fruitflow® in Affecting Platelet Aggregation and Thrombin Generation Capacity in a Randomized, Pilot Study in Male Subjects

Das

Datta

Biswas

et al. 2021

Preprint

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BackgroundWe aimed to investigate the range of intakes linked to efficacy and to make an initial assessment of variability in response to the water-soluble tomato extract, Fruitflow®. Platelet response to ADP agonist and thrombin generation capacity were monitored at baseline and 24h after consuming 0,30,75,150,300mg of Fruitflow® in a randomized, double-blinded crossover study in male subjects 30–65 years of age (n=12, ISRCTN53447583,24/02/2021). ResultsResults showed that the changes from baseline aggregation (-12.0±13.9 to -17.7±15.7%) and thrombin generation (-8.6±4.1 to -11.3±2.3%) achieved for the 75mg, 150mg, and 300mg supplements were equivalent. Effects observed for 0 mg and 30mg supplements were non-equivalent to150mg and not different from baseline (aggregation changed by -0.7±10.2 to 3.0±5.0%, thrombin generation by 0.8±3.1%). ConclusionsThe data suggest that the efficacious range for Fruitflow® lies between 75mg and 300mg, depending on the individual. It may be pertinent to personalize the daily intake of Fruitflow® depending on individual platelet response.

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“…Cardiovascular diseases (CVD) are a leading cause of worldwide death. Thrombosis provoked by increased platelet activity and triggering platelet aggregation is one of the CVD causes (1). Platelets halt blood loss after tissue plasma but excessive platelet aggregation also plays a crucial role in various CVD such as hypertension, arterial disease, heart failure, stroke and atherosclerosis (2,3).…”

Section: Introductionmentioning

confidence: 99%

High-performance thin-layer chromatography fingerprinting, total phenolic and total flavonoid contents and anti-platelet-aggregation activities of Prosopis farcta extracts

Kobarfard

Ayatollahi

Khosravi-Dehaghi

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Cardiovascular diseases are a leading cause of worldwide death and excessive platelet is closely related with their pathogenesis. Different plants and natural compounds have demonstrated anti-platelet effects. The aim of this study was to report the high-performance thin-layer chromatography (HPTLC) fingerprinting and anti-platelet-aggregation activities of different leaf extracts (n-hexane, chloroform, ethyl acetate, methanol and aqueous) of Prosopis farcta (Syrian mesquite) plant. The results showed a 100% inhibition of aggregation activity after plasmatic adenosine diphosphate (ADP) aggregation activation of ethyl acetate, ethanolic, methanolic and aqueous extracts, at 60 mg/mL concentration. The IC 50 ADP value of these extracts ranged between 4.07 and 11.39 mg/mL. Moreover, these extracts reported the highest amounts of phenolic and flavonoid contents. In conclusion, phytochemicals present in P. farcta leaves have anti-platelet-aggregation activities. Future studies are needed to identify the compounds with anti-platelet potential present in P. farcta.

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High Residual Platelet Activity in Response to Acetylsalicylic Acid in Acute Coronary Syndrome: A New Challenge for Antiplatelet Treatment?

Cited by 4 publications

References 21 publications

Thrombosis origin identification of cardioembolism and large artery atherosclerosis by distinct metabolites

Thrombosis origin identification of cardioembolism and large artery atherosclerosis by distinct metabolites

Evaluation of the Equivalence of Different Intakes of Fruitflow® in Affecting Platelet Aggregation and Thrombin Generation Capacity in a Randomized, Pilot Study in Male Subjects

High-performance thin-layer chromatography fingerprinting, total phenolic and total flavonoid contents and anti-platelet-aggregation activities of Prosopis farcta extracts

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