Evaluation of the Equivalence of Different Intakes of Fruitflow® in Affecting Platelet Aggregation and Thrombin Generation Capacity in a Randomized, Pilot Study in Male Subjects

Abstract

BackgroundWe aimed to investigate the range of intakes linked to efficacy and to make an initial assessment of variability in response to the water-soluble tomato extract, Fruitflow®. Platelet response to ADP agonist and thrombin generation capacity were monitored at baseline and 24h after consuming 0,30,75,150,300mg of Fruitflow® in a randomized, double-blinded crossover study in male subjects 30–65 years of age (n=12, ISRCTN53447583,24/02/2021). ResultsResults showed that the changes from baseline aggregation (-12.0±13.9 to -17.7±15.7%) and thrombin generation (-8.6±4.1 to -11.3±2.3%) achieved for the 75mg, 150mg, and 300mg supplements were equivalent. Effects observed for 0 mg and 30mg supplements were non-equivalent to150mg and not different from baseline (aggregation changed by -0.7±10.2 to 3.0±5.0%, thrombin generation by 0.8±3.1%). ConclusionsThe data suggest that the efficacious range for Fruitflow® lies between 75mg and 300mg, depending on the individual. It may be pertinent to personalize the daily intake of Fruitflow® depending on individual platelet response.