Evaluation of Serum Levels of Inflammation, Fibrinolysis and Oxidative Stress
            Markers in Coronary Artery Disease Prediction: A Cross-Sectional Study

Abolhasani, Sakhavat; Shahbazloo, Shahnam Valizadeh; Saadati, Hossein Mozafar; Mahmoodi, Neda; Khanbabaei, Nafiseh

doi:10.5935/abc.20190159

Cited by 18 publications

(17 citation statements)

References 34 publications

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“…MDA level is a useful marker for the severity of CAD and reflecting the presence of easily removed plaque [23], [24]. MDA can be predictive markers of adverse cardiovascular outcomes [25]. Elevated concentration of MDA relates to severe coronary artery calcification in patients with renal disease [26].…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Plasma Neuregulin-1 and MDA Levels with Severity of CAD

Aliska¹,

Fadil²,

Ilhami³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Neuregulins (NRGs) are one of the epidermal growth factors (EGF) superfamily, which released in cellular injuries, such as neurons and myocardial cells. Neuregulin-1β (NRG-1β) could be activated when stress happens to myocardial cells, acting as a survival factor to repair the injury. Malondialdehyde (MDA) is also produced during oxidative stress in cardiac injury. In vivo study of myocardial cells in rats and dogs that got ischemic, dilated, and viral cardiomyopathy showed that NRG-1 could improve the injured cardiac performance, attenuated pathological changes, and prolonged survival of the cells. AIM: We aimed to observe NRG-1 levels in CAD patients in Indonesia, mainly focused in Minang ethnicity. This study also analyzes the relationship between NRG-1 and MDA with CAD’s severity. METHODS: We measured plasma NRG-1 in 61 nondiabetic patients within 38–82 years old range with STEMI, NSTEMI, and UAP. RESULTS: We found their plasma NRG1, respectively, was 10.3 (1.9–38.2) ng/ml, 14.3 ± 7.2 ng/ml, and 7.05 (4.5–0.4) ng/mL. Plasma NRG 1 increased in AMI patients. CONCLUSION: This study concludes that NRG1’s activated during cardiac cells injury, in any AMI.

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Section: Discussionmentioning

confidence: 99%

“…Elevated concentration of MDA relates to severe coronary artery calcification in patients with renal disease [26]. Higher MDA levels mean worse prognosis on CAD who underwent PCI in a recent study [25]. MDA has a stable concentration in blood over 36 h in patients [28].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Plasma Neuregulin-1 and MDA Levels with Severity of CAD

Aliska¹,

Fadil²,

Ilhami³

et al. 2020

Open Access Maced J Med Sci

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“…Abolhasani et al conducted a study showing that the serum concentrations of high-sensitivity C-reactive protein (hs-CRP), sialic acid (SA), vitronectin (VN), plasminogen activator inhibitor-1 (PAI-1), Ox-LDL, and MDA were significantly elevated in patients with CAD relative to the healthy control group [ 132 ]. ROS-mediated lipid peroxidation leads to the formation of unsaturated aldehydes, including acrolein and MDA, which have toxic effects [ 112 ].…”

Section: Oxidative Stress In Coronary Artery Diseasementioning

confidence: 99%

Oxidative Stress in Ischemic Heart Disease

Kibel

Lukinac

Đambić

et al. 2020

Oxidative Medicine and Cellular Longevity

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One of the novel interesting topics in the study of cardiovascular disease is the role of the oxidation system, since inflammation and oxidative stress are known to lead to cardiovascular diseases, their progression and complications. During decades of research, many complex interactions between agents of oxidative stress, oxidation, and antioxidant systems have been elucidated, and numerous important pathophysiological links to na number of disorders and diseases have been established. This review article will present the most relevant knowledge linking oxidative stress to vascular dysfunction and disease. The review will focus on the role of oxidative stress in endotheleial dysfunction, atherosclerosis, and other pathogenetic processes and mechanisms that contribute to the development of ischemic heart disease.

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“…Inflammation causes coronary plaque formation or rupture by adjusting the balance of anti- and pro-inflammatory adipocytokines. 4 , 5 Therefore, inflammatory cells in peripheral blood may be related to the onset and progression of ACS. Inflammatory cells in peripheral blood mainly include neutrophils, monocytes, platelets, and lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of peripheral blood inflammatory cell subsets in patients with acute coronary syndrome undergoing percutaneous coronary intervention

et al. 2021

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Objective This study aimed to investigate the predictive value of inflammatory cells in peripheral blood on the prognosis of patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Methods Patients (n=1558) were consecutively enrolled and the median follow-up was 1142 days. Patients were divided into the major adverse cardiac events (MACE) 1 group (n=63) (all-cause mortality [n=58] and rehospitalization for severe heart failure [n=5], no MACE1 group (n=1495), MACE2 group (n=38) (cardiac mortality [n=33] and rehospitalization for severe heart failure [n=5]), and no MACE2 group (n=1520). The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were analyzed. Results The NLR, MLR, and PLR were higher in the MACE groups than in the no MACE groups. Different subsets of inflammatory cells had similar diagnostic values for MACE. Kaplan–Meier curves showed that the survival time gradually decreased with an increase in the degree of risk as determined by the NLR, MLR, and PLR. The risk of MACE was highest in the extremely high-risk group. Conclusion Peripheral blood inflammatory cell subsets can predict MACE in patients with ACS undergoing PCI. These cell subsets could be important laboratory markers for the prognosis and clinical treatment of these patients.

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Evaluation of Serum Levels of Inflammation, Fibrinolysis and Oxidative Stress Markers in Coronary Artery Disease Prediction: A Cross-Sectional Study

Cited by 18 publications

References 34 publications

Relationship between Plasma Neuregulin-1 and MDA Levels with Severity of CAD

Relationship between Plasma Neuregulin-1 and MDA Levels with Severity of CAD

Oxidative Stress in Ischemic Heart Disease

Prognostic value of peripheral blood inflammatory cell subsets in patients with acute coronary syndrome undergoing percutaneous coronary intervention

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