Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients

Abstract

Background Sirtuins may act in many cellular processes like apoptosis, DNA repair and lipid/glucose metabolism. Experimental studies suggested some sirtuin types may have protective effects against endothelial dysfunction, atherosclerosis, cardiac hypertrophy and reperfusion injury. Data about sirtuins in acute myocardial infarction (AMI) patients are scarce. Objectives To investigate temporal changes of serum sirtuin 1,3 and 6 levels in AMI patients; to compare the serum sirtuin 1,3 and 6 levels between AMI patients and control subjects; and to investigate the association of serum sirtuin 1,3 and 6 levels with prognostic markers of AMI. Methods Forty patients with AMI and 40 patients with normal coronary arteries were included. Left ventricular ejection fraction (LVEF), serum proBNP, CRP, sirtuin1, sirtuin 3 and sirtuin 6 levels were processed. Peak troponin T levels, GRACE score, first day / second day sirtuin levels were recorded of AMI patients. A p value < 0.05 was considered statistically significant. Results Serum sirtuin 1,3 and 6 levels in AMI patients were similar to those in normal coronary patients. No temporal change in serum sirtuin 1,3 and 6 levels were found in AMI course. No correlation was evident between the sirtuin levels and the following parameters: proBNP, CRP, peak troponin and LVEF. Baseline sirtuin 1 and 6 levels were positively correlated with reperfusion duration. Baseline sirtuin 3 levels were negatively correlated with GRACE score. Conclusion Serum sirtuin 1,3 and 6 levels in AMI patients were similar to those in normal coronary patients. This study does not represent evidence of the possible protective effects of sirtuin1, 3 and 6 in AMI patients.

<p>The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis</p>

“…Serum SIRT1 level was found to be significantly higher in patients with LVH compared to those without LVH and to healthy subjects; multivariate logistic regression analysis revealed that increased serum SIRT1 concentration independently predicted LVH in patients with hypertension. Another recent human study on SIRT1 concentration was reported by Kızıltunç et al 39 They assessed temporal changes of serum sirtuin1 in 40 patients with acute myocardial infarction (AMI) compared to subjects with normal coronary arteries and found no differences between AMI patients and the latter group. In our population of patients with end-stage kidney disease on maintenance hemodialysis no differences in sirtuin1 levels between patients with LVH or other known cardiovascular disease and without was found.…”

Involvement of Sirtuins and Klotho in Cardioprotective Effects of Exercise Training Against Waterpipe Tobacco Smoking-Induced Heart Dysfunction

“…Our findings indicated that tobacco consumption reduces the proteins involved in cell survival including SIRT1, SIRT3, and Klotho, and increases the rate of apoptosis ( Figures 5 – 8 ). Many cell functions, such as proliferation, apoptosis, cell survival, and response to stress, are mediated by class III histone deacetylases enzymes through deacetylating target proteins ( Kiziltunc et al, 2019 ). A number of studies have reported that SIRT1, one of the members of class III histone deacetylases enzymes, inhibits apoptosis in cardiomyocytes ( Tanno et al, 2010 ; Yu et al, 2016 ) and its reduction is associated with various cardiovascular pathologies such as cardiac hypertrophy and the severity of heart failure ( Kong et al, 2010 ; Sosnowska et al, 2017 ).…”

Biomarkers of Inflammation and Oxidative stress in the Prediction and Management of Acute Coronary Syndrome

“…The sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases. There are seven closely related SIRT family members (Sirt1-7), and these are divided into four classes (144)(145)(146)(147). The best-known function of SIRTs is deacetylation (148).…”