The Effects of Trimetazidine on QT-interval Prolongation and Cardiac Hypertrophy in
            Diabetic Rats

Ramezani-Aliakbari, Fatemeh; Badavi, Mohammad; Dianat, Mahin; Mard, Seyyed Ali; Ahangarpour, Akram

doi:10.5935/abc.20180248

Cited by 12 publications

(11 citation statements)

References 33 publications

(30 reference statements)

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“…[ 38 ] Another study of the effects of TMZ in diabetic rats also reported that it significantly reduced IL‐6 levels. [ 39 ] These results appear to be inconsistent with the present study, which may be attributable to our research involving acute ischemia and to TMZ reducing macrophage infiltration. TMZ will probably reduce the levels of IL‐1β, which has a wide spectrum of action from autoimmune diseases to sepsis, by preventing the infiltration of macrophages and through different pathways, such as sirtulin‐1.…”

Section: Discussioncontrasting

confidence: 99%

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The protective effects of trimetazidine against ovary ischemia–reperfusion injury via the TLR4/Nf‐kB signal pathway

Ozturk

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Deniz

et al. 2022

J Biochem & Molecular Tox

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Late diagnosis and treatment of ovarian ischemia can lead to worsening of ischemia, irreversible damage to ovarian functions and infertility. In this process, there is no approved medical treatment that can reduce the negative effects of ischemia and contribute positively to ovarian functions during reperfusion after detorsion. Rats were randomly assigned into one of six groups of eight animals each. The groups were designed as follows: The control group, The ischemia(I) group, The Ischemia + Trimetazidine (I + TMZ) (20 mg/kg) group, and The ischemia-reperfusion group (I/R). The Ischemia-Reperfusion + Trimetazidine (I/R + TMZ) (20 mg/kg) group, and The Sham + Trimetazidine (Sham + TMZ) (20 mg/kg) group. In this study performed thiobarbituric acid reactive substances (TBARS), total thiol (-SH), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), toll-like receptor 4 (TLR4), and nuclear factor-kappa B(NF-κβ). Increased oxidative stress and inflammation were as a result of ovarian I and I/R application. Trimetazidine (TMZ), was sufficient to reduce the oxidative stress and inflammation. TLR4 and NF-κβ, which were upregulated by oxidative stress and inflammation, were regressed by TMZ. TMZ should be considered as a potential therapeutic agent in addition to surgery in the clinical treatment of ovarian torsion.

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Section: Discussioncontrasting

confidence: 99%

“…The protective effects of TMZ against endothelial dysfunction and inflammation through an increase in microRNA‐24 are also consistent with these findings. [ 39 ] All these results show that TMZ protects the ovarian follicles against apoptosis and inflammation by regulating the NF‐κβ pathway.…”

Section: Discussionmentioning

confidence: 95%

The protective effects of trimetazidine against ovary ischemia–reperfusion injury via the TLR4/Nf‐kB signal pathway

Ozturk

Topçu

Deniz

et al. 2022

J Biochem & Molecular Tox

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“…Other data supporting ROS participation in this process are that N-acetylcysteine restores total myocardial glutathione, lowers oxidative stress, and reduces myocyte hypertrophy and fibrosis in aortic stenosis rats [ 153 ]. In addition, drugs such as trimetazidine (TZM) decrease cardiac hypertrophy by increasing the level of antioxidant enzymes such as catalase, superoxide dismutase and GSH peroxidase [ 154 ].…”

Section: Role Of Oxidative Stress In the Generation Of Cardiovascular Diseasesmentioning

confidence: 99%

Glutathione Participation in the Prevention of Cardiovascular Diseases

et al. 2021

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Cardiovascular diseases (CVD) (such as occlusion of the coronary arteries, hypertensive heart diseases and strokes) are diseases that generate thousands of patients with a high mortality rate worldwide. Many of these cardiovascular pathologies, during their development, generate a state of oxidative stress that leads to a deterioration in the patient’s conditions associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Within these reactive species we find superoxide anion (O2•–), hydroxyl radical (•OH), nitric oxide (NO•), as well as other species of non-free radicals such as hydrogen peroxide (H2O2), hypochlorous acid (HClO) and peroxynitrite (ONOO–). A molecule that actively participates in counteracting the oxidizing effect of reactive species is reduced glutathione (GSH), a tripeptide that is present in all tissues and that its synthesis and/or regeneration is very important to be able to respond to the increase in oxidizing agents. In this review, we will address the role of glutathione, its synthesis in both the heart and the liver, and its importance in preventing or reducing deleterious ROS effects in cardiovascular diseases.

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“…9 Além das potenciais estratégias não farmacológicas descritas, novas indicações de medicamentos foram contempladas nos estudos publicados nos ABC. Ramezani-Aliakbari et al 10 avaliaram o uso da trimetazidina em ratos com cardiomiopatia diabética. O fármaco, comumente utilizado para melhorar o metabolismo miocárdico na insuficiência coronariana, reduziu o grau de hipertrofia miocárdica e melhorou parâmetros eletrocardiográficos e de função ventricular.…”

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