Catheter Ablation for Atrial Fibrillation in Patients with Heart FailureMauricio
            Scanavacca and Edimar Alcides Bocchi

Scanavacca, Maurício; Bocchi, Edimar Alcides

doi:10.5935/abc.20180066

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…A IC pode predispor um indivíduo à ocorrência de FA através de vários mecanismos, como o aumento da pressão de enchimento do ventrículo esquerdo ou a dilatação e a fibrose do AE, levando à remodelação estrutural e elétrica do átrio. A FA pode aumentar a mortalidade em pacientes com disfunção ventricular esquerda, 68 portanto, o tratamento da FA nesse subconjunto de pacientes é de importância crucial, 69 - 73 dadas as limitações da amiodarona, único medicamento antiarrítmico disponível para esse subgrupo. As mais recentes diretrizes europeias de 2020 referem indicação Classe IIa, 15 com base em estudos comparativos com amiodarona (AATAC) 69 e na publicação de estudos randomizados como o AMICA 74 e CASTLE-AF, 75 este último realizado em pacientes com IC grave (Fração de ejeção média 32%), demonstrando uma redução expressiva na mortalidade ou hospitalização por IC (38%) e na mortalidade cardiovascular (51%).…”

Section: Situações Especiaisunclassified

“…AF can increase mortality in patients with left ventricular dysfunction. 68 Treatment of AF in this subset of patients is of critical importance 69 - 73 given the limitations of Amiodarone, the only antiarrhythmic drug available for this subgroup. In the most recent European guidelines published in 2020, AF ablation in patients with HF received a Class Ia 15 indication based on comparative studies with Amiodarone (AATAC) 69 and the publication of randomized studies such as AMICA 74 and CASTLE-AF, 75 the latter performed in patients with severe HF (mean EF 32%), demonstrating a significant reduction in mortality or hospitalization for HF (38%) and cardiovascular mortality (51%).…”

Section: Special Situationsmentioning

confidence: 99%

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Fibrilação Atrial (Parte 2) – Ablação por Cateter

Saad

d’Ávila²

2021

Arquivos Brasileiros De Cardiologia

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Resumo Após mais de 20 anos desde sua utilização inicial, a ablação por cateter se tornou um procedimento rotineiramente realizado para tratamento de pacientes com fibrilação atrial (FA). Fundamentado inicialmente no isolamento elétrico das veias pulmonares em pacientes com FA paroxística, subsequentes avanços no entendimento da fisiopatologia levaram a técnicas adicionais não só para obter melhores resultados, mas também para tratar pacientes com formas persistentes de arritmia, assim como pacientes com cardiopatia estrutural e insuficiência cardíaca.

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Section: Situações Especiaisunclassified

Section: Special Situationsmentioning

confidence: 99%

Fibrilação Atrial (Parte 2) – Ablação por Cateter

Saad

d’Ávila²

2021

Arquivos Brasileiros De Cardiologia

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“…For example, the common RFA strategy for VT is to identify a clinically relevant scar tissue and deliver ablative energy to homogenize the scar. However, the effects of RFA on fibrotic tissue are not fully understood [3]. Conduction velocity (CV) slowing is one of the determinants for AF and VT vulnerability [4].…”

Section: Introductionmentioning

confidence: 99%

Cell Unexcitability and Electrotonic Coupling Phenomenon Analysis of Ablation-Created Lesions: A Study Case with Ablated Explanted Human Heart

Paredes¹,

Salinet²,

Crowley³

et al. 2022

Computing in Cardiology Conference (CinC)

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This study investigates the effects of radiofrequency ablation (RFA)-created lesions on an explanted human heart in wedge preparation by simultaneous endo and sub-endo optical mapping. The heart in Langendorff perfusion was ablated under 40 W. The ventricle was stained with Vm sensitive dye Di-4-ANBDQPQ and two excitation light bands of different penetration depths were used (red = 660 nm, green = 525 nm) to perform a conduction velocity (CV) difference analysis for identification of CV alternans. The relative change in fluorescence (∆F/F) traces were analyzed before and after ablation. Local activation time (LAT) was determined by the 50% approach. Local CV was obtained using the circle method, and RFA created lesions were characterized by examining the CV alternans correlated with transmural heterogeneities. The presence of CV alternans results from reduced excitability in a non-homogeneous lesion consisting of excitable and non-excitable cells. The absence of CV alternans in optical mapping with green light and their presence with deep-red light illustrates incomplete ablation across the ventricular wall or non-homogeneous ablation in the mid-myocardial layer. The presence of an intramural scar impairs the efficacy of the RFA procedure, suggesting a need for alternative ablations strategies.

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Catheter Ablation for Atrial Fibrillation in Patients with Heart FailureMauricio Scanavacca and Edimar Alcides Bocchi

Cited by 2 publications

References 15 publications

Fibrilação Atrial (Parte 2) – Ablação por Cateter

Fibrilação Atrial (Parte 2) – Ablação por Cateter

Cell Unexcitability and Electrotonic Coupling Phenomenon Analysis of Ablation-Created Lesions: A Study Case with Ablated Explanted Human Heart

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