Large Accumulation of Collagen and Increased Activation of Mast Cells in Hearts of
            Mice with Hyperlipidemia

Cheng, Yunpeng; Zhu, Yanqiu; Zhang, Jia-shu; Duan, Xingping; Zhang, Ying

doi:10.5935/abc.20170143

Cited by 13 publications

(12 citation statements)

References 20 publications

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“…In the study of hyperlipidemia on the heart tissue, the expression of chymase increased in the experimental group compared to the control group (5). Studies have shown that MCTCs increase in the urinary bladder lamina propria (25), mucosa, and detrusor layer as a result of interstitial cystitis (38).…”

Section: Discussionmentioning

confidence: 97%

Effect of probiotic on mast cell density and expression of tryptase, chymase, and TNF-α in the urinary bladder of rats with high cholesterol

Ertuğrul

Tütüncü

Çiftçi

2022

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Section: Discussionmentioning

confidence: 97%

Effect of probiotic on mast cell density and expression of tryptase, chymase, and TNF-α in the urinary bladder of rats with high cholesterol

Ertuğrul

Tütüncü

Çiftçi

2022

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…Cell proliferation was measured in real-time using the xCELLigence system (Roche Applied Science, Penzberg, Germany) ( 18 ). This system measures electrical impendence caused by adherent cells to evaluate proliferation in real time ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

MicroRNA-327 regulates cardiac hypertrophy and fibrosis induced by pressure overload

Qiu

Shen

et al. 2018

Int J Mol Med

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MicroRNA (miRNA/miR) dysregulation has been reported to be fundamental in the development and progression of cardiac hypertrophy and fibrosis. In the present study, miR-327 levels in fibroblasts were increased in response to cardiac hypertrophy induced by transverse aortic constriction with prominent cardiac fibrosis, particularly when compared with the levels in unstressed cardiomyocytes. In neonatal rat cardiac fibroblasts, induced expression of miR-327 upregulated fibrosis-associated gene expression and activated angiotensin II-induced differentiation into myofibroblasts, as assessed via α-smooth muscle actin staining. By contrast, miR-327 knockdown mitigated angiotensin II-induced differentiation. Cardiac fibroblast proliferation was not affected under either condition. In a mouse model subjected to transverse aortic constriction, miR-327 knockdown through tail-vein injection reduced the development of cardiac fibrosis and ventricular dysfunction. miR-327 was demonstrated to target integrin β3 and diminish the activation of cardiac fibroblasts. Thus, the present study supports the use of miR-327 as a therapeutic target in the reduction of cardiac fibrosis.

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“…Capsaicin was shown to cause a decrease in the number of MC TC s in rat ovarian tissue (44). In an experimental hyperlipidemia study, it was mentioned that chymase expression increased in the experiment group in comparison to the control group (7). It has also been shown that trauma, which stimulates the immune system, causes an increase in the number of MC TC s (45).…”

Section: M M U N O H I S T O C H E M I C a L F I N D I N G S C H Y M A S Epositive Mast Cellsmentioning

confidence: 99%

Possible effect of thymoquinone on mast cell number and chymase, IL-4, IFN-γ expression in rat spleen

Ertuğrul¹,

Tütüncü²,

Ozdemir³

et al. 2021

Medycyna Weterynaryjna

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Thymoquinone (TQ) has been widely used in traditional medicine for the treatment of many diseases, to support the circulatory and immune system and to protect general health. Moreover, it is used as a nutritional supplement for preventive and therapeutic purposes in the respiratory, digestive and urinary systems. Secretion granules in the cytoplasm of mast cells contain primary mediators such as histamine, neutral proteases such as tryptase and chymase, and cytokines such as interleukin-4 (IL-4) and interferon-gamma (IFN-γ). 35 Sprague Dawley adult female rats were used as the study material. The rats were randomly assigned to five groups. First group: 1 ml/kg dose and second group: 2 ml/kg dose of TQ prepared at 1/1 (v/v) of ethanol and saline was intraperitoneally injected regularly in the rats daily for 42 days. Third group: 10 mg/kg dose and fourth group: 20 mg/kg dose of TQ was administered orally with the aid of a gavage probe. Fifth group was the control group in which no intervention was made. The lowest number of mast cells was detected in the group administered TQ at a dose of 20 mg/kg by oral gavage. It was determined that the numbers of mast cells in the control group and the group treated with TQ at a dose of 1 ml/kg intraperitoneally were close to each other. It was concluded that the increase or decrease between groups in the distribution of mast cells, chymase, IL-4, and IFN-γ cytokine expression may be partially effected in the spleen tissue by substances such as TQ.

show abstract

Large Accumulation of Collagen and Increased Activation of Mast Cells in Hearts of Mice with Hyperlipidemia

Cited by 13 publications

References 20 publications

Effect of probiotic on mast cell density and expression of tryptase, chymase, and TNF-α in the urinary bladder of rats with high cholesterol

Effect of probiotic on mast cell density and expression of tryptase, chymase, and TNF-α in the urinary bladder of rats with high cholesterol

MicroRNA-327 regulates cardiac hypertrophy and fibrosis induced by pressure overload

Possible effect of thymoquinone on mast cell number and chymase, IL-4, IFN-γ expression in rat spleen

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