Plasma Total Antioxidant Capacity and Cardiometabolic Risk in Non-Obese and Clinically Healthy Young Adults

Abstract

BackgroundThe oxidative biomarkers play an important role in the genesis of cardiometabolic risk-related processes.ObjectiveTo investigate the total antioxidant capacity of plasma and its association with cardiometabolic risk in non-obese and clinically healthy young adults.MethodsUniversity students of the state of Sergipe, Brazil, aged between 18 and 25 years, were recruited for this study from May of 2013 and October of 2014. Anthropometric, clinical and biochemical parameters were measured and analyzed using protocols which were previously standardized and described in the literature. The measurement of plasma total antioxidant capacity was based on the ability that all the antioxidants present in the sample (plasma) have to inhibit the oxidation of the oxidizable substrate ABTS (2,2`- Azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS•+ by metmyoglobin.ResultsApproximately 25% of the sample presented more than one component of cardiometabolic risk. Low HDL-cholesterol was the most prevalent component. Compared to absence of components, the subjects with at least one component presented greater body weight and waist circumference, higher levels of diastolic blood pressure and fasting glucose, greater total cholesterol/HDL-c ratio, and lower levels of HDL-c (p < 0.05). Fasting glycemia was the only parameter which was associated with total antioxidant capacity (R2 = 0.10; β = 0.17; p = 0.001).ConclusionsThe plasma total antioxidant capacity was not able to predict the cardiometabolic risk components due possibly to the establishment of compensatory mechanisms that become activated in physiological conditions.

Total Antioxidant Status and Other Markers to Distinguish Severely Obese Volunteers with and without Metabolic Syndrome

“…Costa et al [32] did not find any association of TAC with higher levels of body weight, waist circumference, diastolic blood pressure, total cholesterol HDL-C ratio, and lower HDL-C in non-obese clinically healthy young adults, and concluded that this may be due to compensatory mechanisms that get activated in physiological conditions. This viewpoint is supported by other studies [31] where MDA increased but TAC was not affected. This has been attributed to an increase in antioxidant enzymes such as SOD, supporting the hypothesis that homeostatic mechanisms involving the antioxidant enzymes are able to produce sufficient adaptation to keep the total antioxidant levels unaffected in some conditions but not in others.…”

“…Ravi Kiran et al [28] found a lower TAC in diabetic and MetS respondents, Picu et al [29], found low TAS along with low antioxidant enzymes, suggesting a strong association between T2DM and obesity, insulin resistance and OS, Bakhtiyari et al [30] reported a far greater effect of MetS than age on OS in senior women, as indicated by a strong correlation of high TG and low HDL-C, with MDA and TAC. Hopps et al [31] found significantly lower TAS in MetS non-diabetics but not in diabetic MetS respondents, and like us, they concluded that the evaluation of TAS may be a useful marker in the monitoring of MetS.…”

Effect of tannic acid-templated mesoporous silica nanoparticles on iron-induced oxidative stress and liver toxicity in rats

“…In several studies, TAC has been introduced as one of the leading indicators of oxidative stress [ 46 , 47 ]. Therefore, this study measured TAC through DPPH and FRAP assays.…”

Relationship between antioxidant status and attention deficit hyperactivity disorder among children

“…The findings of Hatice Sezen, regarding the overall antioxidant status, was consistent with this study results. [40] TAC is one of the important indicators of oxidative stress,[41] as it determines the synergistic effect of different antioxidant compounds in the sample. However, TAC does not evaluate all the antioxidant components and the important role of enzymes such as SOD, CAT, and GPX; consequently, the data should be interpreted with caution.…”