Total Antioxidant Status and Other Markers to Distinguish Severely Obese Volunteers with and without Metabolic Syndrome

Singh, Sharmistha; Dwivedi, Astha; Kumar, Shashank; Mittal, Poonam

doi:10.4236/fns.2019.106048

Cited by 3 publications

(1 citation statement)

References 26 publications

(20 reference statements)

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“…Nevertheless, obesity may impact the relationship between oxidative stress biomarkers and MetS. For example, obesity is associated with low systemic antioxidant defenses and enhanced lipid peroxidation, as indicated by elevated MDA levels [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Increased Aldehyde Formation as a Key Component of the Metabolic Syndrome in Adolescents: A Machine Learning Study

Bonifácio¹,

Maes²,

Farias³

et al. 2020

Preprint

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Purpose: To investigate the alterations in nitro-oxidative stress (OS) and antioxidant status in adolescents with metabolic syndrome (MetS) and whether these alterations occur independently from effects of overweight or obesity.Methods: Blood was collected in 47 adolescents with MetS and 94 adolescents without MetS as assessed with the International Diabetes Federation criteria. The International Obesity Task Force (IOTF) criteria were used to classify the subjects into those with overweight or obesity. We measured nitro-oxidative biomarkers including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), and malondialdehyde (MDA), and antioxidant biomarkers, i.e. total radical-trapping antioxidant parameter (TRAP), paraoxonase (PON)-1 activity, thiol (SH-) groups, as well as tumor necrosis factor-α, glucose, insulin, triglycerides, uric acid and high-density lipoprotein cholesterol (HDL-C).Results: Logistic regression analysis showed that increased MDA and NOx and a lowered TRAP/uric acid ratio were associated with MetS. Machine learning including soft independent modeling of class analogy (SIMCA) showed that the top-3 most important features of MetS were increased glucose and MDA and lowered HDL-C. Support vector machine using MDA, glucose, insulin, HDL-C, triglycerides and body mass index as input variables yielded a 10-fold cross-validated accuracy of 89.8% when discriminating MetS from controls. The association between MetS and increased MDA was independent from the effects of overweight-obesity. glucose, insulin, triglycerides and HDL-C.Conclusion: In adolescents, increased MDA formation is a key component of MetS, indicating that increased production of reactive oxygen species with consequent lipid peroxidation and aldehyde formation participate in the development of MetS.

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Section: Introductionmentioning

confidence: 99%

Increased Aldehyde Formation as a Key Component of the Metabolic Syndrome in Adolescents: A Machine Learning Study

Bonifácio¹,

Maes²,

Farias³

et al. 2020

Preprint

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show abstract

Effect of Nicotine Abuse on Oxidative Stress and Perceived Stress and Its Relationship With Coping Self Efficacy Among University Graduates

Kumar¹,

Dwivedi²,

Mishra³

et al. 2020

JEBAS

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An interdisciplinary review of the literature portrayed stress as an important cause for nicotine abuse among university students. Independent studies have shown nicotine to contribute perceived stress (PS) and oxidative stress (OS) but its mediation relation with PS and OS remains unclear and inspires active exploration. A prominent study on the relationship of smoking with perceived stress and coping styles in adolescents motivates to study the effect of nicotine abuse (NA) on PS, CSE, and OS indices among young adult university graduates. The study sample included 45 university graduates with 1-3 years of tobacco abuse history and 50 age-matched controls. The respondents were compared for perceived stress scale (PSS) score, coping self-efficacy (CSE) score, erythrocyte malondialdehyde (E_MDA), plasma MDA (P_MDA), erythrocyte superoxide dismutase (E_SOD), and plasma catalase (P_CAT). The study found NA increased the PS but not the CSE. Linear regression analysis showed a strong inverse relation between the PSS Score and CSE Score in the controls. Among the biochemical indices of OS, only P_MDA showed a significant difference between the groups. Multiple regressions showed a significant positive association of E_MDA with PSS Score and a significant negative association of E_SOD with PSS Score across the groups. Further, the mediation model is used to show a significant relationship between NA and PSS Score by Combined MDA (C_MDA). The result of study suggested that nicotine increases PS and reduces CSE. P_MDA is an important biochemical marker of nicotine abuse. E_MDA and E_SOD are important predictors of PS. These findings are important for psychobiochemical interventions in the management of NA. Therefore, this study encourages an interdisciplinary discourse on nicotine abuse with psychological and biochemical measures.

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Comparative Study of Inflammatory and Oxidative Stress Biomarkers in Different Metabolically Healthy Obesity Phenotypes

Dwivedi¹,

Kumar²,

Singh³

et al. 2020

FNS

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Total Antioxidant Status and Other Markers to Distinguish Severely Obese Volunteers with and without Metabolic Syndrome

Cited by 3 publications

References 26 publications

Increased Aldehyde Formation as a Key Component of the Metabolic Syndrome in Adolescents: A Machine Learning Study

Increased Aldehyde Formation as a Key Component of the Metabolic Syndrome in Adolescents: A Machine Learning Study

Effect of Nicotine Abuse on Oxidative Stress and Perceived Stress and Its Relationship With Coping Self Efficacy Among University Graduates

Comparative Study of Inflammatory and Oxidative Stress Biomarkers in Different Metabolically Healthy Obesity Phenotypes

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