Assessment of Carotid Intima-Media Thickness as an Early Marker Of Vascular Damage In Hypertensive Children

Baroncini, Liz Andréa Villela; Sylvestre, Lucimary de Castro; Baroncini, Camila Varotto; Pecoits‐Filho, Roberto

doi:10.5935/abc.20170043

Cited by 18 publications

(15 citation statements)

References 34 publications

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“…Baroncini et al found significant correlation between carotid IMT and hypertension, but no significant correlation with age, gender and BMI in hypertensive children (21). In our study with adult CKD patients, we found carotid IMT was significantly associated with age, BMI, iPTH and CCI, but with no difference between males and females.…”

Section: Fgf 23 and Imt In Chronic Kidney Disease 45contrasting

confidence: 54%

FGF23 Level and Intima‐Media Thickness Are Elevated From Early Stages of Chronic Kidney Disease

Figurek

Spasovski²,

Popović-Pejičić

2017

Ther Apher Dial

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Considering high cardiovascular (CV) risk in chronic kidney disease (CKD), the aim of this crosssectional study was to assess the association between carotid intima-media thickness (IMT) and fibroblast growth factor (FGF) 23 as important players in CV pathophysiology. Eighty-seven patients with mean estimated glomerular filtration rate 40.1 mL/min per 1.73 m 2 were involved. FGF23 and IMT were elevated from early stages of CKD. Mean IMT value was 1.10 ± 0.20 mm, being significantly elevated starting from early CKD, showing no correlation with FGF23 (r = À0.01, P = À0.91). Unlike the FGF23 level that followed worsening of kidney function, IMT was increasing only in the initial CKD stages, with no further increase from CKD stage 3 on. Although we found no direct association between current use of vitamin D and statin therapy, this may be associated with the sustained reference values of lipid and vitamin D status under treatment that further preclude worsening of IMT in patients with advanced CKD.

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Section: Fgf 23 and Imt In Chronic Kidney Disease 45contrasting

confidence: 54%

FGF23 Level and Intima‐Media Thickness Are Elevated From Early Stages of Chronic Kidney Disease

Figurek

Spasovski²,

Popović-Pejičić

2017

Ther Apher Dial

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“…Other studies have also shown that glucose and LDL levels in adolescents with hypertension are higher and HDL is lower than those without hypertension with or without a family history of hypertension [15]. This result was also strengthened from further analysis of the Riskesdas 2013 by Sihombing which showed that the risk of hypertension in DM respondents increased in the age group ≥45 years by 2.63 times, mental emotional disorders 2.19 times, central obesity 1.75 times, total cholesterol 1.68 times, general obesity 1.57 times, not working 1.39 times, low education 1.30 times with p <0.05 [16]. In addition, analysis of previous cohort studies of risk factors NCD data conducted by Sirait and Riyadina showed that incidents hypertension that appeared in one year period (2012) from Kebon Kalapa respondents was 16.8%, while risk factors related to the incidence of hypertension included age, education (low and medium), nutritional status (overweight and obese) and stress [17].…”

Section: Discussionmentioning

confidence: 89%

Risk Factors for Newly Diagnosed Hypertensive at Non-Diabetes Participants: A Cohort Study in Central Bogor, Indonesia

Sulistiowati¹,

Sihombing²

2020

Proceedings of the 4th International Symposium on Health Research (ISHR 2019)

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Hypertension is a major contributor to cardiovascular disease. Hypertension is known as the silent killer disease. The patients do not feel any symptoms or asymptomatic and for a long time, if it is not be cured they will get some complications. The prevalence of hypertension is rising in the world including Indonesia. This aim of the study is to assess the risk factors for newly diagnosed hypertension at non-diabetes respondents in the Cohort Study of Risk Factors for Non-Communicable Diseases in Central Bogor. We conducted a prospective study, the sample was respondents from baseline data Cohort Study 2011-2012 that they were not diagnosed hypertensive with JNC VII criteria, and not diabetes mellitus with ADA criteria (3984 persons), conducted follow-up for 6 years. Data collected by interviews, physical examinations (weight, height, abdominal circumference, blood pressure), and laboratories (fasting plasma glucose and 2 hours after loading 75 g of glucose, total cholesterol, HDL, LDL, triglycerides). We used multiple logistic regression for analysis and odd ratios with 95% confidence intervals were calculated to identify risk factors associated with hypertension. The incidence of hypertension increases every year and proportion of cumulative in 6 years was 770 persons (19.32%), 219 mens (28.4%) and 551 womens (71.6%). Hypertensive participants had higer levels for fasting plasma glucose and 2 hours after loading, triglycerides and LDL than normotensive (p<0.001). Risk factors assosiated with hypertension are age ≥45 years (OR=1.31; 95% CI=1.114-1.549), obesity (OR=1.89; 95% CI=1.592-2.250), diabetes (OR=2.31; 95% CI=1.674-3.182), high LDL (OR=1.59; 95% CI=1.303-1.947), and stress (OR=2.5; 95% CI=1.985-3.166) with p ≤ 0.05. Age, obesity, diabetes, high LDL and stress are important risk factors associated with hypertension. Most of the risk factors can be modified and require prevention efforts with lifestyle changes.

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“…The estimated sample size was based on a previous study on CIMT, which required the highest number of sample size compared to CRP, PWVcf, and AI. The mean difference of CIMT between the healthy subjects and with those at risk was 0.04 mm (Baroncini et al 2017), with an alpha value of 0.05, a power value of 80%, and a standard deviation of 0.05 mm. The sample size was calculated based on the formula by Eng (2003).…”

Section: Methodsmentioning

confidence: 90%

Vascular Markers among Young Women with CVD Risk Factors

Aminuddin¹,

Ugusman²,

Salamt³

et al. 2019

JSM

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Data pertaining to carotid intima-media thickness (CIMT), carotid-femoral pulse wave velocity (PWVcf), augmentation index (AI), and C-reactive protein (CRP) are less studied among young Asian women. The objectives of this study were to determine the associations between these vascular markers with other cardiovascular (CVD) risk factors and future CVD risks; and secondly, to determine the associations between the markers themselves among young women. One hundred and forty-eight young women who were healthy, or having any CVD risk factor, were recruited. They were divided into a healthy group (HG, n=71) and a risk group (RG, n=77). The parameters measured included body anthropometry, blood pressure (BP), CIMT, PWVcf, AI, CRP, blood sugar, and lipid profiles. The future CVD risk was expressed in short and long term Framingham Risk Scores (FRS). The data was analysed via SPSS and p-value <0.05 was accepted as significant. The RG had significantly higher PWVcf, AI, and hs-CRP when compared to HG. All of the markers were associated with CVD risk factors and the long-term FRS. The independent variable for CIMT was age (R 2 =0.11), while PWVcf was determined by diastolic BP and age (R 2 =0.29). AI was independently determined by age, heart rate, and LDL (R 2 =0.28), while for CRP, it was weight and HDL (R 2 =0.30). In conclusion, among the young women with CVD risk factor, CIMT, PWVcf, AI, and hs-CRP can be used to assess their risk of future CVD. No associations were observed between the markers themselves, which suggests that every marker reflects a different entity. They should be measured independently for a complete vascular assessment. ABSTRAKMaklumat berkaitan ketebalan intima media arteri karotid (CIMT), halaju gelombang nadi arteri karotid femor (PWVcf), indeks augmentasi (AI) dan protein C-Reaktif (CRP) kurang dikaji dalam kalangan belia wanita Asia. Objektif kajian ini adalah menentukan hubungan antara penanda saluran darah tersebut dengan faktor-faktor risiko CVD yang lain serta risiko CVD pada masa depan, dan kedua adalah untuk menentukan hubungan penanda saluran darah tersebut sesama sendiri dalam kalangan wanita muda. Seramai seratus empat puluh lapan wanita muda yang sihat atau mempunyai faktor risiko CVD direkrut. Mereka dibahagikan kepada kumpulan sihat (HG, n=71) dan kumpulan berisiko (RG, n=77). Parameter yang diukur meliputi antropometri badan, tekanan darah (BP), CIMT, PWVcf, AI, CRP, glukosa darah dan profil lipid. Risiko CVD pada masa depan dibentangkan dalam bentuk Skor Risiko Framingham (FRS) jangka masa panjang dan pendek. Data dianalisis menggunakan SPSS dan nilai p<0.05 diterima sebagai signifikan. Kumpulan RG mempunyai PWVcf, AI dan Hs-CRP yang lebih tinggi apabila dibandingkan dengan HG. Kesemua penanda saluran darah ini mempunyai hubungan dengan faktor risiko CVD dan FRS jangka masa panjang. Variabel tidak bersandar bagi CIMT adalah umur (R 2 =0.11) sementara PWVcf ditentukan oleh BP diastolik dan umur (R 2 =0.29). AI ditentukan secara bebas oleh umur, kadar nadi dan LDL (R 2 =0.30) manak...

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Assessment of Carotid Intima-Media Thickness as an Early Marker Of Vascular Damage In Hypertensive Children

Cited by 18 publications

References 34 publications

FGF23 Level and Intima‐Media Thickness Are Elevated From Early Stages of Chronic Kidney Disease

FGF23 Level and Intima‐Media Thickness Are Elevated From Early Stages of Chronic Kidney Disease

Risk Factors for Newly Diagnosed Hypertensive at Non-Diabetes Participants: A Cohort Study in Central Bogor, Indonesia

Vascular Markers among Young Women with CVD Risk Factors

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