Association Between Hemodynamic Profile, Physical Capacity and Quality of Life in Pulmonary Hypertension

Abstract

BackgroundNo studies have described and evaluated the association between hemodynamics, physical limitations and quality of life in patients with pulmonary hypertension (PH) without concomitant cardiovascular or respiratory disease.ObjectiveTo describe the hemodynamic profile, quality of life and physical capacity of patients with PH from groups I and IV and to study the association between these outcomes.MethodsCross-sectional study of patients with PH from clinical groups I and IV and functional classes II and III undergoing the following assessments: hemodynamics, exercise tolerance and quality of life.ResultsThis study assessed 20 patients with a mean age of 46.8 ± 14.3 years. They had pulmonary capillary wedge pressure of 10.5 ± 3.7 mm Hg, 6-minute walk distance test (6MWDT) of 463 ± 78 m, oxygen consumption at peak exercise of 12.9 ± 4.3 mLO2.kg-1.min-1 and scores of quality of life domains < 60%. There were associations between cardiac index (CI) and ventilatory equivalent for CO2 (r=-0.59, p <0.01), IC and ventilatory equivalent for oxygen (r=-0.49, p<0.05), right atrial pressure (RAP) and 'general health perception' domain (r=-0.61, p<0.01), RAP and 6MWTD (r=-0.49, p<0.05), pulmonary vascular resistance (PVR) and 'physical functioning' domain (r=-0.56, p<0.01), PVR and 6MWTD (r=-0.49, p<0.05) and PVR index and physical capacity (r=-0.51, p<0.01).ConclusionPatients with PH from groups I and IV and functional classes II and III exhibit a reduction in physical capacity and in the physical and mental components of quality of life. The hemodynamic variables CI, diastolic pulmonary arterial pressure, RAP, PVR and PVR index are associated with exercise tolerance and quality of life domains.

Association of daily physical activity with psychosocial aspects and functional capacity in patients with pulmonary arterial hypertension: a cross‐sectional study

“…In this study, the mean walking distance in the 6MWT was 451.5 ± 96.4 m, which is slightly higher than that found in a Brazilian registry (398 ± 152 m) 22 and similar to another Brazilian study, which reported 463 ± 78 m. 23 The figures from these Brazilian studies are higher than those reported in other registries, such as the American registry with 374 ± 129 m 24 and the French registry with 329 ± 109 m. 25 We observed a strong correlation between accelerometer data and 6MWT distance, a finding similar to other studies that also used an accelerometer to assess PA in patients with PAH. 3,19…”

Cuidado De Enfermagem Na Atenção Primária À Criança Com Síndrome De Williams-Beuren: Uma Revisão Integrativa

“…No acompanhamento de pacientes com hipertensão pulmonar, diversos aspectos são norteadores de decisões terapêuticas e determinantes do prognóstico (TORRES et al, 2015). Nos últimos anos, vários biomarcadores da HP foram investigados com o intuito de buscar um método eficiente e não invasivo de estratificação e monitorização (PLÁCIDO et al, 2017).…”