Brugada-Like Electrocardiographic Changes Induced by Hypokalemia

Gazzoni, Guilherme Ferreira; Borges, Anibal Pires; Bergoli, Luis Carlos Corsetti; Soares, J.; Kalil, Carlos; Bartholomay, Eduardo

doi:10.5935/abc.20130073

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…We have established six etiological categories of BrP 2-4 along with a systematic approach to diagnose BrP 3 by excluding sodium channel dysfunction in the myocardium. The presented case by Gazzoni et al 1 would possibly qualify under category (i) metabolic conditions; however, further analysis of this case report is required.…”

Section: Dear Editormentioning

confidence: 87%

“…We read with great interest the case report by Gazzoni et al 1 regarding a Brugada ECG pattern induced by hypokalemia. This paper is important because it contributes to the growing body of literature describing Brugada Phenocopies (BrP) 2-5 .…”

Section: Dear Editormentioning

confidence: 94%

“…We are establishing an international registry database at www.burgadaphenocopy.com and invite Gazzoni et al 1 to submit this case along with future cases to the registry should they satisfy the BrP diagnostic criteria 3 . The goal of this registry is to provide long-term follow-up and insight into the pathophysiology and natural history of patients presenting with BrP.…”

Section: Dear Editormentioning

confidence: 99%

See 2 more Smart Citations

Possible Brugada Phenocopy Induced by Hypokalemia in a Patient with Congenital Hypokalemic Periodic Paralysis

Anselm

Genaro

Baranchuk

2013

Arquivos Brasileiros De Cardiologia

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Section: Dear Editormentioning

confidence: 87%

Section: Dear Editormentioning

confidence: 94%

Section: Dear Editormentioning

confidence: 99%

See 1 more Smart Citation

Possible Brugada Phenocopy Induced by Hypokalemia in a Patient with Congenital Hypokalemic Periodic Paralysis

Anselm

Genaro

Baranchuk

2013

Arquivos Brasileiros De Cardiologia

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Brugada Phenocopies: Consideration of Morphologic Criteria and Early Findings From an International Registry

Anselm

Gottschalk

Baranchuk

2014

Canadian Journal of Cardiology

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Brugada phenocopy: A new electrocardiogram phenomenon

Anselm

Evans

Baranchuk

2014

WJC

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Brugada phenocopies (BrP) are clinical entities that are etiologically distinct from true congenital Brugada syndrome. BrP are characterized by type 1 or type 2 Brugada electrocardiogram (ECG) patterns in precordial leads V1-V3. However, BrP are elicited by various underlying clinical conditions such as myocardial ischemia, pulmonary embolism, electrolyte abnormalities, or poor ECG filters. Upon resolution of the inciting underlying pathological condition, the BrP ECG subsequently normalizes. To date, reports have documented BrP in the context of singular clinical events. More recently, recurrent BrP has been demonstrated in the context of recurrent hypokalemia. This demonstrates clinical reproducibility, thereby advancing the concept of this new ECG phenomenon. The key to further understanding the pathophysiological mechanisms behind BrP requires experimental model validation in which these phenomena are reproduced under strictly controlled environmental conditions. The development of these validation models will help us determine whether BrP are transient alterations of sodium channels that are not reproducible with a sodium channel provocative test or alternatively, a malfunction of other ion channels. In this editorial, we discuss the conceptual emergence of BrP as a new ECG phenomenon, review the progress made to date and identify opportunities for further investigation. In addition, we also encourage investigators that are currently reporting on these cases to use the term BrP in order to facilitate literature searches and to help establish this emerging concept.

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Brugada-Like Electrocardiographic Changes Induced by Hypokalemia

Cited by 3 publications

References 14 publications

Possible Brugada Phenocopy Induced by Hypokalemia in a Patient with Congenital Hypokalemic Periodic Paralysis

Possible Brugada Phenocopy Induced by Hypokalemia in a Patient with Congenital Hypokalemic Periodic Paralysis

Brugada Phenocopies: Consideration of Morphologic Criteria and Early Findings From an International Registry

Brugada phenocopy: A new electrocardiogram phenomenon

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