Brugada Phenocopies: Consideration of Morphologic Criteria and Early Findings From an International Registry

Coronary anomalies resulting in ischemia induced Brugada Phenocopy

“…BrPs are clinical entities that present with ECGs identical to those found in Brugada Syndrome (BrS) but are the result of various clinical circumstances [2,3]. They may be induced by a number of clinical conditions that are characterized into six etiological categories: (i) metabolic conditions; (ii) mechanical compression; (iii) myocardial ischemia & pulmonary embolism; (iv) myocardial & pericardial disease; (v) ECG modulations; and (vi) miscellaneous [4].…”

Brugada Phenocopy as a Dynamic Electrocardiographic Pattern during Acute Anterior Myocardial Infarction

“…This remains an important task to be resolved since ischemia may either induce a BrP or, inversely, unmask a true congenital BrS . In this clinical situation, current criteria allowed us to confirm the diagnosis of Type‐1, Class B BrP . Although the case presented here would require a challenge with a sodium channel blocker (ajmaline, flecainide, or procainamide), we did not perform these tests given the severe life‐threatening clinical situation and complete reversal of the ECG pattern once myocardial ischemia resolved.…”

“…Conditions inducing BrP can be characterized into six etiologic categories: metabolic disorders, mechanical compression, pulmonary embolism and myocardial ischemia, myocardial and pericardial diseases, ECG modulations, and miscellaneous . A systematic approach to diagnose BrP is very useful to differentiate between this entity and BrS (Table ) …”

Link between Brugada phenocopy and myocardial ischemia: Results from the International Registry on Brugada Phenocopy

“…Brugada phenocopy (BrP) is a clinical condition characterized by ECG patterns identical to those found in BrS yet are elicited by various clinical conditions . Upon resolution of the underlying condition, the ECG pattern normalizes (Table ) . Given the low diagnostic yield of genetics in “true BrS,” genetic testing is not a mandatory criterion for the diagnosis of BrP (Table ).…”

“…[2][3][4] Upon resolution of the underlying condition, the ECG pattern normalizes (Table 1). [5][6][7] Given the low diagnostic yield of genetics in "true BrS," genetic testing is not a mandatory criterion for the diagnosis of BrP (Table 1). Myocardial ischemia commonly induces a range of ECG changes including modulations of the ST-segment and production of the Brugada ECG pattern.…”