Resistance Training Controls Arterial Blood Pressure in Rats with L-NAME- Induced Hypertension

Araujo, Ayslan Jorge Santos de; Santos, Anne Carolline Veríssimo dos; Souza, Karine dos Santos; Aires, Marlúcia Bastos; Santana‐Filho, Valter Joviniano; Fioretto, Emerson Ticona; Mota, Marcelo Mendonça; Santos, Márcio Roberto Viana dos

doi:10.5935/abc.20130051

Cited by 26 publications

(35 citation statements)

References 29 publications

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“…A number of studies have reported that exercise reduces blood pressure in both hypertensive and normotensive subjects [12][13][14] . Although the mechanisms by which regular exercise reduces blood pressure are not completely clear [15][16][17] , the benefits of physical activity may accrue through reduction of other cardiovascular risk factors, such as improved glucose tolerance 18 or lower BMI and visceral fat 19 , resulting in a lower occurrence of comorbidities associated with hypertension 20 . In addition, long-term regular physical activity preserves cardiac compliance 21 , endothelial regulation of smooth muscle tone and other aspects of vascular wall structure/function 22 , workload and cardiac performance 23 .…”

Section: Discussionmentioning

confidence: 99%

Exercise, Blood Pressure and Mortality: Findings of Eight Years of Follow-Up

Turi

Bonfim

Codogno

et al. 2017

Rev Bras Med Esporte

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Introduction: In the last decades, unhealthy habits, such as low levels of physical activity and poor diet, have increased. Consequently, the prevalence of cardiovascular diseases and mortality has increased significantly among adults. However, it is known that regular physical exercises help to improve health outcomes. Thus, the aim of this study was to analyze the effects of eight years of regular participation in an exercise program on blood pressure and mortality in the Brazilian public health system. Methods: The sample consisted of 34 participants with hypertension and/or type II diabetes who were followed up for eight years. They were paired by age, body mass index and chronic disease in two groups: exercise and control. During the follow-up period, medical records were used to assess systolic and diastolic blood pressure, as well as number of medical appointments and the occurrence of deaths. Results: In the follow-up period, five participants died in the control group and none in the exercise group. The Kaplan-Meier analysis identified 29.4% lower mortality among active participants (Fisher's exact test with p = 0.044). The number of medical appointments and the values of diastolic blood pressure were significantly lower for active participants. Conclusion: After a follow-up of eight years, participants in the exercise group attended fewer medical appointments, had better blood pressure control and a lower occurrence of deaths.

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Section: Discussionmentioning

confidence: 99%

Exercise, Blood Pressure and Mortality: Findings of Eight Years of Follow-Up

Turi

Bonfim

Codogno

et al. 2017

Rev Bras Med Esporte

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“…This is in large part due to the fact that the etiology of hypertension is multifactorial in nature and it is as of yet unclear how these factors interact to contribute to the development of hypertension. Recent findings from animal studies suggest aerobic exercise may prevent increases in BP through beneficial alterations in insulin sensitivity and autonomic nervous system function[71], while resistance training may prevent increases in BP through beneficial alterations in vasoconstriction regulation[72]. Proposed mechanisms through which physical activity may prevent the development of hypertension are summarized in table 2.…”

Section: Mechanismsmentioning

confidence: 99%

Physical Activity and the Prevention of Hypertension

2013

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As the worldwide prevalence of hypertension continues to increase, the primary prevention of hypertension has become an important global public health initiative. Physical activity is commonly recommended as an important lifestyle modification that may aid in the prevention of hypertension. Recent epidemiologic evidence has demonstrated a consistent, temporal, and dose-dependent relationship between physical activity and the development of hypertension. Experimental evidence from interventional studies have further confirmed a relationship between physical activity and hypertension as the favorable effects of exercise on blood pressure reduction have been well characterized in recent years. Despite the available evidence strongly supporting a role for physical activity in the prevention of hypertension, many unanswered questions regarding the protective benefits of physical activity in high-risk individuals, the factors that may moderate the relationship between physical activity and hypertension, and the optimal prescription for hypertension prevention remain. We review the most recent evidence for the role of physical activity in the prevention of hypertension and discuss recent studies that have sought to address these unanswered questions.

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“…SNP is an antihypertensive drug that by an increased in the release of nitric oxide, relaxed smooth muscle of vessels and reduces blood pressure [18, 19]. In this study pretreatment of SNP significantly attenuate the effect of L-NAME on SBP and MAP.…”

Section: Discussionmentioning

confidence: 72%