Neutrophil-Lymphocyte Ratio in Cardiovascular Disease Risk Assessment

Santos, Heitor O.; Izidoro, Luíz Fernando Moreira

doi:10.5935/2359-4802.20180038

Cited by 15 publications

(12 citation statements)

References 4 publications

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“…The NLR has recently been a focus of attention, especially in cardiovascular disease. The NLR has been proposed for use in risk stratification of many cardiovascular diseases, including aortic stenosis [18,19] and heart failure [7]. A high NLR is associated with poor clinical outcomes in various cardiac diseases, including acute coronary syndrome, stable coronary disease, non-STsegment elevation myocardial infarction (NSTEMI), and STEMI [20,21].…”

Section: Overall (N ═ 97)mentioning

confidence: 99%

The Impact of Transcatheter Aortıc Valve Implantatıon on Neutrophıl to Lymphocyte Ratıo: A Retrospective Study

Afşin¹,

Kavalcı²,

Ulutaş³

et al. 2019

Int J Clin Cardiol

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Background: Transcatheter aortic valve implantation (TAVI) has become a novel therapeutic option for patients with severe aortic stenosis who have been considered inoperable or high risk for conventional surgical aortic valve replacement. The aim of this study was to determine the effect of TAVI on neutrophil to lymphocyte ratio (NLR). Methods: A total of 97 patients with severe aortic valve stenosis undergoing TAVI in our clinic were included in the study. The patients were divided into two groups based on valve type; patients with CoreValve bioprosthesis (n = 56) and patients with Edwards SAPIEN-XT bioprosthesis (n = 41). Blood samples were drawn before TAVI and were performed at 1 and 6 months after TAVI. Results: The patients in the Edwards SAPIEN group were older than the patients in the CoreValve group (76.7 ± 6.6 years, p = 0.019). Eurologistic score (p = 0.002), choronic obstructive pulmonary disease (p = 0.006), and pulmonary arterial pressure-systole (p = 0.001) were significantly higher in patients in the CoreValve group than those in the Edwards SAPIEN group. Aortic valve area had increased in both groups after the procedure (p < 0.001 and p < 0.001, respectively). In addition, interventricular septal wall thickness, posterior wall thickness, and left ventricular mass index regressed in both groups at 6 month follow-up (p < 0.001, p < 0.001, and p < 0.001, respectively). When compared with the baseline NLR, a significant decrease was observed in the values at 1 and 6 months in both groups (p < 0.001 and p < 0.001, respectively). Conclusions: A decrease in the NLR can be both a sign of regression of valvular inflammation and myocardial hypertrophy in patients with degenerative aortic stenosis after TAVI. Our results show that it may be used during the follow-up of patients with TAVI.

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Section: Overall (N ═ 97)mentioning

confidence: 99%

The Impact of Transcatheter Aortıc Valve Implantatıon on Neutrophıl to Lymphocyte Ratıo: A Retrospective Study

Afşin¹,

Kavalcı²,

Ulutaş³

et al. 2019

Int J Clin Cardiol

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“…Altered adipose tissue and adipocyte function negatively influence the ability of the endothelium to produce nitric oxide and prostacyclin. This causes depletion of vasodilator, antithrombotic and anti-atherogenic properties affecting CV fitness [18] Atherosclerotic plaques having activated macrophages and T-cell lymphocytes multiply and spawn an augmented inflammatory response [19] further increasing the CV risk [20]. EDF has also been linked to the fatigued state of a person.…”

Section: Introductionmentioning

confidence: 99%

Effect of Oxyjun™ on Adipose Tissue Inflammation - A Randomized, Placebo-Controlled Clinical Study

Srivastava

Girandola

Kokate

2020

Int. J. Phys. Educ. Fit. Sports

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The objective of the study was to explore the effect of Oxyjun™ on the cardiovascular function of overweight people by reducing obesity induced systemic inflammation. Males aged between 18 - 35 years and body mass index of 25 - 34.9 kg/m2 were recruited in the study. Participants were randomized on baseline visit in two groups to receive either single dose of 400 mg of Oxyjun™ and placebo (for 8-weeks. Participants were evaluate for obesity related inflammation and quality of life using the change in neutrophil lymphocyte ratio (NLR), high density lipoprotein (HDL-c) and 36 items short form survey (SF-36). NLR was reduced by 0.71 in the Oxyjun™ group and by 0.42 in the placebo group. Within group comparison was significant for Oxyjun™ when compared from baseline (p<0.001) and reduction of NLR in Oxyjun™ group was more than 1.5 times higher than that of placebo. HDL-c levels were improved in the Oxyjun™ group with an increase of 4.04 mg/dL whereas, HDL-c was reduced in the placebo group by 1.22 mg/dL; p=0.09. Further, SF-36 health concepts of fatigue, mental health, and social function showed significant improvement and also the pain scores were improved. No adverse or serious adverse events were reported for the Oxyjun™ as well as the placebo group during the study. Oxyjun™ reduced the NLR of participants demonstrating its potential for lowering adipose tissue induced inflammation. Further, increased HDL levels in Oxyjun™ group can assist in promoting cardiovascular fitness and prevent the risk of future cardiovascular events.

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“…The neutrophil to lymphocyte ratio (NLR) is being used as a rapidly accessible, cheap, non-invasive and valuable marker for the assessment of systemic inflammation in general practice (8). The calculation of NLR from routine complete blood count is being used as a prognostic factor in many cancers (9).…”

Section: Introductionmentioning

confidence: 99%

Retrospective Analysis of the Effects of Neutrophil / Lymphocyte Ratio on Intraoperative Acidosis Development and Hospitalization Time in Patients Underwent Radical Robotic Prostatectomy

Görgülü¹,

Dinc²,

Ertuğ³

2018

Akd Med J

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Objective: This study aimed the predictive value of the neutrophil to lymphocyte ratio (NLR) for intraoperative acidosis and postoperative lenght of hospital stay in patients undergoing robotic assisted radical prostatectomy procedure. Material and Methods: Patients with locally advanced prostate cancer undergoing elective robotic assisted radical prostatectomy procedure were included in the study. Inclusion criteria was being ASA I-II, and receiving sugammadex for recovery of neuromuscular block. Complete blood counts and blood-gas analyses were performed perioperatively. The neutrophil to lymphocyte ratio was calculated by dividing neutrophil counts to lymphocyte counts. Acidosis was defines as pH levels below 7.35. Results: A total of forty-six patients (mean age 64.06±6.4 years) were included. Blood gas changes were detected in twenty three patients. Eighteen patients in the study population had combined acidosis. Twelve patients had acidosis according to pH levels, seven patients had PaCO2 ≥ 45 mmHg, and seven patients had Lactate ≥1.6 mmol/L. Median hospital stay was five days (0-10 days). NLR levels were not found to be significantly different between the groups, and were not correlated with patient age (p=0.907) or duration of hospital stay (p=0.654). Conclusion: NLR was not found to be a marker for acidosis or predictive of prolonged hospital stay in patients undergoing the RARP procedure.

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Neutrophil-Lymphocyte Ratio in Cardiovascular Disease Risk Assessment

Cited by 15 publications

References 4 publications

The Impact of Transcatheter Aortıc Valve Implantatıon on Neutrophıl to Lymphocyte Ratıo: A Retrospective Study

The Impact of Transcatheter Aortıc Valve Implantatıon on Neutrophıl to Lymphocyte Ratıo: A Retrospective Study

Effect of Oxyjun™ on Adipose Tissue Inflammation - A Randomized, Placebo-Controlled Clinical Study

Retrospective Analysis of the Effects of Neutrophil / Lymphocyte Ratio on Intraoperative Acidosis Development and Hospitalization Time in Patients Underwent Radical Robotic Prostatectomy

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