Safflower Oil (Carthamus tinctorius L.) Intake Increases Total Cholesterol and LDL-cholesterol Levels in an Experimental Model of Metabolic Syndrome

Abstract

Background: Overweight has been considered an important public health problem. To reverse this situation, various types of treatment are proposed. The safflower oil (Carthamus tinctorius L.) has been used in the prevention/ treatment of obesity.

Effect of safflower oil (Carthamus tinctorius L.) supplementation in the abdominal adipose tissues and body weight of male Wistar rats undergoing exercise training

“…However, our results showed that safflower oil had no effect on the blood glucose levels. Similar results were demonstrated by Santana et al (2017) , who found no effect on glucose levels in rats that received safflower oil supplementation by gavage (1.0 ml/1,000 g of animal weight, for 10 weeks). These differences in the results could be explained by the different methods of oil administration, since one study demonstrated its effects after treatment by gavage ( Santana et al, 2017 ) and the other after including it in the diet ( Zhang et al, 2010 ).…”

“…Results of studies that evaluated the effect of safflower oil on biochemical parameters remained controversial, which may be due to the differences in experimental protocols. Santana et al (2017) evaluated the therapeutic effects of safflower oil supplementation administered by gavage (1.0 ml/1,000 g of animal weight, for 10 weeks) in an experimental model of metabolic syndrome, and their results showed an increase in TC and LDL cholesterol levels. Crescenzo et al (2015) demonstrated that after 2 weeks of consuming a safflower-linseed oil-based diet (L), the male Sprague-Dawley rats exhibited no differences in TG levels but presented a significant reduction in TC levels compared with rats fed with a lard-based diet.…”

“…Studies have shown that safflower oil is effective in reducing TC levels in exogenously hypercholesterolemic rats ( Sato, Yoshida, Nagao, & Imaizumi, 2000 ) and in altering the adipocytic adiposity-related gene expression, resulting in the effective amelioration of diet-induced obesity in mice ( Zhang, Li, Liu, Sun, & Zhang, 2010 ). However, other studies suggest that safflower oil supplementation can have possible deleterious effects on the lipid profile as it increased the levels of TC and low-density lipoprotein (LDL)-cholesterol in male Wistar rats but had no effects on the abdominal adipose tissue weight ( Takeuchi et al, 1995 , Santana et al, 2017 ). Moreover, studies on the effects of safflower oil in combination with aerobic exercise on obesity is limited.…”

Morphological Characteristics of Safflower Seedlings Under Compaction Levels in a Clayey Latosol

“…It is considered an important medicinal plant (Soleymani, 2017), as its oil is currently used as a thermogenic compound, also used in the treatment of cardiovascular problems (Toma, 2014). Several studies have shown that dietary supplementation with safflower oil had a positive effect on the lipid profile, with an antiatherogenic function (Santana et al, 2017).…”

O uso de fitoterápicos e plantas medicinais em processo de redução de peso: analisando prescrições nutricionais

“…Entre os seus componentes estão presentes os ácidos graxos, poliinsaturados e os monoinsaturados, alcaloides e flavonoides. Alguns estudos indicam que podem agir na prevenção das dislipidemias, aterosclerose e saciedade, o que pode colaborar para perda de gordura corporal (SANTANA et al, 2017;SCHULTZ et al, 2014 Costuma ser citada em estudos com objetivo de atenuar processos relacionados a ansiedade e estresse, esses efeitos são atribuídos a presença de terpenos e flavonoides presentes na sua composição (PACÍFICO et al, 2018;CAETANO et al, 2015). (SOUZA et al, 2015;SCHLEIER et al, 2016).…”