Peripheral Th17/Treg cell-mediated immunity imbalance in allergic rhinitis patients**Please cite this article as: Huang X, Chen Y, Zhang F, Yang Q, Zhang G. Peripheral Th17/Treg cell-mediated immunity imbalance in allergic rhinitis patients. Braz J Otorhinolaryngol. 2014;80:152-5, ****Study conducted at Third Hospital, Sun Yat-sen University, Guangdong, China

Huang, Xianbo; Chen, Yulian; Zhang, Fucheng; Yang, Qintai; Zhang, Gehua

doi:10.5935/1808-8694.20140031

Cited by 49 publications

(20 citation statements)

References 13 publications

(12 reference statements)

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“…In the study of Ciprandi and colleagues, serum IL-17 levels of AR patients were detected higher than those of controls and also, a positive correlation was indicated between serum IL-17 level and SS [ 28 ]. In another study, it was shown that serum IL-17 level in AR patients was higher while TGF- β level was lower than that in controls [ 29 ]. In our study and in many studies of literature mentioned above, it was shown that Th17 cells were active in a period when both SAR and PAR patients are symptomatic.…”

Section: Discussionmentioning

confidence: 99%

Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35

et al. 2018

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Background We aimed in our study to research the role of new cytokines such as IL-35, IL-22, and IL-17 that may form a target for novel treatment approaches. Methods IL-10, IL-17, TGF-β, IFN-γ, IL-22, and IL-35 serum levels of allergic rhinitis (AR) patients were measured using ELISA method. Allergic sensitization was demonstrated by the skin prick test. Patients only with olive tree sensitivity were evaluated for seasonal AR (SAR). Patients only with mite sensitivity were included in the study for perennial AR (PAR). AR clinic severity was demonstrated by the nasal symptom scores (NSS). Results In total, 65 AR patients (patient group), having 31 PAR and 34 SAR patients, and 31 healthy individuals (control group) participated in the study. Cytokine levels between the patient group and the control group were compared; IL-17 (p = 0.038), IL-22 (p = 0.001), and TGF-β (p = 0.031) were detected as high in the patient group, and IFN-γ (p < 0.001) was detected as low in the patient group. When correlation analysis was made between age, gender, prick test result, NSS, AR duration, and cytokine levels in the patient group, a negative correlation was detected only between IFN-γ (p = 0.032/r = −0.266) level and NSS. Conclusions Accompanied by the literature information, these results made us think that T cell subgroups and cytokines have an important role in AR immunopathogenesis. It is thought that future studies to be conducted relating to this subject will form new targets in treatment.

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Section: Discussionmentioning

confidence: 99%

Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35

et al. 2018

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“…T h 17/T reg cell imbalance has been associated with airway allergic inflammation ( 23 , 24 ). A previous study demonstrated that the FOXP3 + T reg cell count in the nasal mucosa of allergic mice increased significantly following IB treatment ( 1 ), which was consistent with the current results of enhanced nasal mucosa FOXP3 mRNA expression following IB treatment.…”

Section: Discussionmentioning

confidence: 99%

Effects of anticholinergic agent on miRNA profiles and transcriptomes in a murine model of allergic rhinitis

Hou

Xie

et al. 2017

Molecular Medicine Reports

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Anticholinergic agent, ipratropium bromide (IB) ameliorates symptoms of allergic rhinitis (AR) using neuroimmunologic mechanisms. However, the underlying molecular mechanism remains largely unclear. In the present study, 27 mice with AR induced by ovalbumin were randomly allocated to one of three groups: Model group, model group with IB treatment for 2 weeks, and model group with IB treatment for 4 weeks. Allergic symptoms were evaluated according to symptoms scores. Differentially expressed genes [microRNAs (miRNAs) and messenger RNAs (mRNAs)] of nasal mucosa were identified by microarray analysis. The expression levels of candidate genes were measured by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The data indicates that the symptoms scores in allergic mice were significantly reduced by IB treatment. In the nasal mucosa of allergic mice with IB treatment, 207 mRNAs and 87 miRNAs were differentially expressed, when compared with the sham group. IB treatment significantly downregulated the expression levels of interleukin-4Rα and prostaglandin D2 synthase, whereas the leukemia inhibitory factor, A20 and nuclear receptor subfamily 4, group A, member 1 expression levels were upregulated. Similarly, the expression levels of mmu-miR-124-3p/5p, −133b-5p, −133a-3p/5p, −384-3p, −181a-5p, −378a-5p and −3071-5p were significantly increased. RT-qPCR data further validated these mRNA and miRNA expression levels. Thus, IB treatment regulated expression of allergic immune-associated mRNAs and miRNAs of the nasal mucosa in allergic mice, which may be associated with ameliorated nasal allergic symptoms.

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“…In a murine AR model, antibody mediated neutralization of IL-17 resulted in less eosinophil and neutrophil infiltration and lower Th2 and Th17 cytokine levels in nasal mucosa [ 16 ]. Elevated Th17 percentages and serum IL-17A levels have been reported in AR patients compared to controls [ 18 , 20 , 21 ] and a reduction of circulating Th17 cells after successful AIT has been reported [ 19 ]. A more recent study did not observe changes in Th17 numbers and function in AR patients during pollen season [ 22 ].…”

Section: Blood Cells In Armentioning

confidence: 99%

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

Jordakieva

Jensen‐Jarolim²

2018

World Allergy Organization Journal

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Allergic rhinitis (AR) is an IgE-mediated inflammatory disease of the nasal mucosa with well described local immune responses during allergen exposure. The frequent association of AR with general extra-nasal symptoms and other allergic conditions, such as conjunctivitis and asthma, however, support a more systemic disease impact. In addition to acute elevation of soluble inflammatory mediators in periphery blood, a growing number of studies have reported changes in circulating blood cells after specific nasal allergen challenge or environmental allergen exposure. These findings imply an involvement of specific blood leukocyte subsets, thrombocytes and recently, erythrocytes. This review summarizes the circulating blood cell dynamics associated with allergen exposure in AR subjects reported so far. Additionally, the impact of therapy, particularly allergen-specific immunotherapy (AIT), the only currently available causal treatment reducing AR-related symptoms, is further considered in this context.

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Abstract: The imbalance of peripheral Th17/Treg cells plays an important role in the pathogenesis of AR.

Cited by 49 publications

References 13 publications

Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35

Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35

Effects of anticholinergic agent on miRNA profiles and transcriptomes in a murine model of allergic rhinitis

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

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