The impact of environmental factors on quality of life and symptoms of children with allergic rhinitis

Castro, Therezita M. Peixoto Patury Galvão; Marinho, Diogo; Cavalcante, Camila Carvalho

doi:10.5935/1808-8694.20130102

Cited by 9 publications

(3 citation statements)

References 21 publications

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“…The symptoms are often at their worst in children and in people in their 30s and 40s. The severity of symptoms tends to vary throughout life; many people experience periods when they have no symptoms at all [32]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Hyeonggaeyeongyo-Tang in Ovalbumin-Induced Allergic Rhinitis Model

Hong

Kim

Choi

et al. 2014

Mediators of Inflammation

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Allergic rhinitis (AR) is an allergic inflammation of the nasal airways. The prevalence of AR is increasing worldwide. We investigated whether Hyeonggaeyeongyo-tang (HYT) is effective to suppress the progression of AR induced by ovalbumin (OVA). Male BALB/c mice were used for this study. Allergic rhinitis was induced by OVA. Treatment with HYT was assessed to study the effect of HYT on allergic rhinitis in mice. Histological analysis, immunohistochemistry, multiplex cytokine assay, blood analysis, and cell viability assay were performed to verify inhibitory effect of HYT on allergic rhinitis. HYT did not show any toxicity maintaining body weight. Food intake was steady without variation in mice. HYT reduced infiltration of inflammatory cells and mast cells into nasal cavity. HYT reduced the levels of cytokines and leukocytes in the blood. HYT decreased the splenocyte cell viability. Antihistamines and steroids are the most common medications used to treat allergic rhinitis. However, long-term use of drug generates resistance or side effects requiring the development of new drug. Our present study clearly demonstrates that HYT suppresses the progression of allergic rhinitis induced by OVA. This suggests that HYT might be a useful drug for the treatment of allergic rhinitis.

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Section: Discussionmentioning

confidence: 99%

Effects of Hyeonggaeyeongyo-Tang in Ovalbumin-Induced Allergic Rhinitis Model

Hong

Kim

Choi

et al. 2014

Mediators of Inflammation

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Environmental factors may also have an impact on symptoms, including pain and the occurrence of complications such as photosensitivity, deficiencies, the cancer risk and infections. [6][7][8][9][10][11][12] Individual disease burden has already been evaluated in several skin diseases using patient questionnaires such as topic dermatitis, vitiligo hand eczema, haemangioma, inherited ichthyosis, sensitive skin and very recently psoriasis. [13][14][15][16][17] Even though it has become the main focus in the management of dermatological diseases, no methodology allowing the design of patient-oriented burden questionnaires in dermatology has been proposed so far.…”

Section: Introductionmentioning

confidence: 99%

<p>A Method for Designing a Patient Burden Questionnaire in Dermatology</p>

Ezzedine¹,

Bennani²,

Shourick³

et al. 2020

CCID

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Introduction In recent years, the concept of “disease burden” has been given a central role in evaluating patient care, particularly in skin diseases. Measuring patient-reported outcomes (PRO) such as symptoms and disease burden may be useful. Aim To present a methodology that facilitates the development and validation of burden questionnaires for patients suffering from skin diseases. Methodology Based on past published burden questionnaires, a methodology for designing skin disease burden questionnaires was to be developed. Results Based on 16 burden questionnaires developed and published over the last 10 years, the authors propose a standardized methodology for the easy design and validation of disease burden questionnaires for patients with chronic skin diseases. The authors provide detailed guidance for the conception, development and validation of the questionnaires, including reliability, internal consistency, external validity, cognitive debriefing, testing–retesting, translation and cross-cultural adaptation, as well as for statistical analysis. Conclusion The proposed methodology enhances the design and validation of disease burden questionnaires in dermatology. Burden questionnaires may be used in clinical research as well as in daily clinical practice.

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Nasal obstruction during adolescence induces memory/learning impairments associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone levels

Ogawa

Okihara

Kokai

et al. 2018

J of Neuroscience Research

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The hippocampus is an important brain region involved in memory and learning. Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B (TrkB), and phospho-p44/p42 mitogen-activated protein kinase (MAPK) are known to contribute to hippocampal memory/learning. The present study aimed to clarify the effects of nasal obstruction during the growth period on memory/learning in an animal model, using combined behavioral, biochemical, and histological approaches. Male BALB/C mice underwent unilateral nasal obstruction (UNO) by cauterization at 8 days of age and were subjected to Y-maze and passive avoidance tests at 15 weeks of age. The serum corticosterone levels were measured using an enzyme-linked immunosorbent assay, and brain tissues were subjected to hematoxylin-eosin staining and histological analysis or homogenization and Western blot analysis. Compared with control mice, UNO mice had lower blood oxygen saturation levels and exhibited apparent memory/learning impairments during behavioral testing. Additionally, the UNO group had higher hippocampal BDNF levels and serum corticosterone levels, lower hippocampal TrkB and phospho-p44/p42 MAPK levels, and reduced neuron numbers relative to controls. Our findings suggest that UNO during adolescence affects the hippocampus and causes memory/learning impairments.

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The impact of environmental factors on quality of life and symptoms of children with allergic rhinitis

Abstract: The studied environmental factors were not correlated with patient quality of life. However, the analysis of patient households and symptoms indicates the environment played a role in the onset of allergy events.

Cited by 9 publications

References 21 publications

Effects of Hyeonggaeyeongyo-Tang in Ovalbumin-Induced Allergic Rhinitis Model

Effects of Hyeonggaeyeongyo-Tang in Ovalbumin-Induced Allergic Rhinitis Model

<p>A Method for Designing a Patient Burden Questionnaire in Dermatology</p>

Nasal obstruction during adolescence induces memory/learning impairments associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone levels

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