Effects of Hyeonggaeyeongyo-Tang in Ovalbumin-Induced Allergic Rhinitis Model

Abstract

Allergic rhinitis (AR) is an allergic inflammation of the nasal airways. The prevalence of AR is increasing worldwide. We investigated whether Hyeonggaeyeongyo-tang (HYT) is effective to suppress the progression of AR induced by ovalbumin (OVA). Male BALB/c mice were used for this study. Allergic rhinitis was induced by OVA. Treatment with HYT was assessed to study the effect of HYT on allergic rhinitis in mice. Histological analysis, immunohistochemistry, multiplex cytokine assay, blood analysis, and cell viability assay were performed to verify inhibitory effect of HYT on allergic rhinitis. HYT did not show any toxicity maintaining body weight. Food intake was steady without variation in mice. HYT reduced infiltration of inflammatory cells and mast cells into nasal cavity. HYT reduced the levels of cytokines and leukocytes in the blood. HYT decreased the splenocyte cell viability. Antihistamines and steroids are the most common medications used to treat allergic rhinitis. However, long-term use of drug generates resistance or side effects requiring the development of new drug. Our present study clearly demonstrates that HYT suppresses the progression of allergic rhinitis induced by OVA. This suggests that HYT might be a useful drug for the treatment of allergic rhinitis.

Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis

“…Loerbroks et al ( 32 ) reported that the prevalence of asthma among obese women was almost twice as high as among normal weight women, and a causal relationship between asthma and incident weight gain cannot be excluded. In an animal model study, Hong et al ( 33 ) observed that normal group mice exhibited increased weight compared with AR mice. The current study indicated that food intake was decreased and that weight increase was lower in AR group mice.…”

Mahuang Fuzi Xixin Decoction Attenuates Th1 and Th2 Responses in the Treatment of Ovalbumin-Induced Allergic Inflammation in a Rat Model of Allergic Rhinitis

“…Researchers have successfully established different animal models of AR by using OVA as an allergen and Al(OH) 3 as an adjuvant [35, 36]. In this study, a rat model of AR was successfully established through intraperitoneal injection of OVA and Al(OH) 3 suspension and nasal instillation with 5% OVA solution.…”

Hyeonggaeyeongyo‐Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre‐Post Study

“…In a previous animal study, HYT had antiallergic effects, inhibiting the increase of the levels of IL-4, IL-13, leukemia inhibitory factor (LIF), eosinophils, neutrophils, monocytes, basophils, lymphocytes, and WBC in ovalbumin-induced AR model [ 10 ]. Based on previous studies, we hypothesized that IgE and eosinophils will be suppressed in patients with AR; however, current study showed no decrease in IgE and eosinophils in AR patients.…”

“…Park and Hong reported that HYT has anti-inflammation effects for AR via the suppression of NF- κ B activation and iNOS production in BALB/c mice [ 9 ]. Hong et al reported that HYT reduces infiltration of inflammatory cells and mast cells into the nasal cavity and reduces the levels of cytokines and leukocytes in the blood in an ovalbumin-induced AR model [ 10 ]. In a clinical study, HYT has shown effectiveness in the treatment of adult patients with acne vulgaris [ 11 ].…”