Sialadenoma papilliferum of the tongue mimicking a malignant tumor

Santos, Jean Nunes dos; Barros, Ângela Ferreira; Gurgel, Clarissa Araújo Silva; Ramalho, Luciana Maria Pedreira

doi:10.5935/1808-8694.20130071

Cited by 3 publications

(4 citation statements)

References 6 publications

(18 reference statements)

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“…It also presented acanthosis and parakeratosis as described in the literature (38). Some of our findings were also reported in other cases, such as chronic inflamation cells in connective tissue (3,10,12,30), epithelium with hyperkeratosis and parakeratosis (2,3,11,19,20), hyperplastic epithelium (2,19,26), epithelium with focal hypergranulosis (19), and spongiosis in squamous epithelium (19).…”

Section: Discussionsupporting

confidence: 87%

“…The youngest patient, two years old, was reported by Sawyer in 1986 (34), and the fourth youngest patient with SP, to our knowledge, is presented in this paper. Our bibliometric study (Online Resource 1) found only three SP cases published in Brazil (T Table 1), and all of them occurred in adult patients (11,18), which makes this case the first one involving a young patient in Brazil. The reason adults are more frequently affected is uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…The IHC studies were performed to determine SP’s histogenesis, which is still unclear (4,10,18). The following antibodies were used in these studies : AE1/AE3, carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), cytokeratin (CK) 7, CK13, CK14, CK19, Ki-67, P40, P63, vimentin, smooth muscle actin (SMA), and SM-100 (3,4,10,11,18,19,31). A normal salivary gland presents CKs 14, 13, 7, 8, and 19 (all of them found in the SP immunoprofile) but does not stain for vimentin or smooth muscle actin (18).…”

Section: Discussionmentioning

confidence: 99%

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Sialadenoma papilliferum: Bibliometric analysis

Vasconcelos¹,

Gerber²,

Saraiva³

et al. 2019

J Clin Exp Dent

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BackgroundSialadenoma papilliferum is a benign rare condition of salivary glands showing a characteristic papillary growth of the ductal epithelium that ends up being confused with more frequent lesions of the oral cavity. Objectives: To perform a bibliometric analysis of all articles about Sialadenoma papilliferum in the oral cavity and to add a singular case report of Sialadenoma in the lower lip.Material and MethodsA total of 36 publications referring to Sialadenoma papilliferum in the oral cavity from the PubMed platform was reviewed. The specific data were collected, and a bibliometric analysis was performed using Microsoft Excel. The results obtained were then compared with this new case report.ResultsThe people most affected with sialadenoma were white males at the average age of 56. The lesion was asymptomatic, usually white or red, with an average size of 1.4 cm, and the palate was by far the most affected site. The majority of the lesions were excised, and only two cases indicated recurrence.ConclusionsWith surgical removal, Sialadenoma papilliferum has a favorable prognosis and no further treatment is required. Due to few recorded cases of recurrence, a long follow-up period is recommended to ensure that the lesion does not redevelop. Key words:Sialadenoma papilliferum, salivary gland, oral cavity, bibliometric analysis.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sialadenoma papilliferum: Bibliometric analysis

Vasconcelos¹,

Gerber²,

Saraiva³

et al. 2019

J Clin Exp Dent

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“…Santos et al also reported a case of SP on the tongue with apparently malignant clinical aspects, which led to the clinical diagnosis of squamous cell carcinoma [40].…”

Section: Possible Malignant Transformationmentioning

confidence: 99%

Intraoral Sialadenoma Papilliferum: A Comprehensive Review of the Literature with Emphasis on Clinical and Histopathological Diagnostic Features

Antonelli

Almeida

Bologna-Molina

et al. 2022

Oral

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Background. Sialadenoma papilliferum (SP) is a rare benign epithelial tumor of salivary gland origin, its diagnosis being potentially challenging. It was first described by Abrams and Finck in 1969 as an analog of the cutaneous syringocystadenoma papilliferum. The aim of this comprehensive review is to highlight the clinical and histopathological diagnostic aspects of intraoral SP, analyzing cases previously described and reporting new cases. Methods. Medline, Scopus, and Web of Science were searched up to February 2022, using as entry term “sialadenoma papilliferum”. No time limits were applied and only studies in English were taken into account. Only cases involving the mouth were included. Conference proceedings, personal communications, and letters to the editor were excluded. Results. In total, 42 out of 234 articles fulfilled the inclusion criteria, with 64 cases reported. Mean age of patients with SP was 57.2 years, with a higher prevalence among males. The most affected site was the palate, particularly the hard palate. Four cases with uncertain malignant features have been reported. While clinical manifestations of SP are rather unspecific (e.g., submucosal swelling with ulceration), histopathological and immunohistochemical features are quite peculiar, SP have a limited growth potential, leading to conservative excision as treatment of choice. Conclusions. SP, though rare, should be taken into consideration in the differential diagnosis of intraoral swellings, particularly those located on the palate.

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