The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs

Amora, Luciana de Albuquerque Salviano; Murashima, Adriana de Andrade Batista; Rossato, Maria; Moreira, Márcia Bento; Hyppolito, Miguel Ângelo; Fagundes, Djalma José

doi:10.5935/1808-8694.20130060

Cited by 8 publications

(4 citation statements)

References 19 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Limited numbers of studies have investigated the role of HBO in ototoxicity. Amora et al [22] suggested that HBO therapy did not change the electrophysiological thresholds of guinea pigs treated with amikacin. However, Yassuda et al [6] found that HBO therapy had a protective effect on cisplatin ototoxicity in albino guinea pigs.…”

Section: Discussionmentioning

confidence: 99%

Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?

Cobanoglu

Vuralkan

Arslan³

et al. 2019

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?

Cobanoglu

Vuralkan

Arslan³

et al. 2019

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…AMK has been shown to significantly enhance the ABR threshold shifts in guinea pigs (21). Similarly, in this study, we found that AMK-induced hearing injury in mice followed by the common characteristics of aminoglycoside ototoxicity, and more severe damage was caused at a higher frequency.…”

Section: Discussionmentioning

confidence: 99%

FoxO3a plays a key role in the protective effects of pomegranate peel extract against amikacin-induced ototoxicity

Liu

Zhang

Sun

et al. 2017

International Journal of Molecular Medicine

View full text Add to dashboard Cite

The use of amikacin (AMK) in present treatment strategies results in severe ototoxicity; however, the underlying molecular mechanisms of this toxicity remain unclear. In this study, we investigated the effectiveness of orally administered pomegranate peel extract (PPE), a strong antioxidant, as a protective agent against AMK-induced ototoxicity. To this end, PPE was orally administered to adult BALB/c mice for 5 days, and the mice were then concurrently treated with AMK (500 mg/kg/day for 15 consecutive days). Auditory threshold shifts induced by AMK were significantly attenuated. The results of immunohistochemical staining and western blot analysis revealed that PPE exerted its protective effects by by downregulating the phosphorylation of Forkhead box O3a (FoxO3a), an important transcription factor which is involved in the responses to oxidative stress. The results also showed that PPE treatment inhibited mitogen-activated protein kinase phosphorylation, prevented the activation of pro-apoptotic protein caspase-3, decreased the levels of apoptosis-inducing Bax protein, and increased the levels of the anti-apoptotic mediator, Bcl-2, induced by AMK in the mouse cochlea. Taken together, our experimental findings suggest that phosphorylated FoxO3a mediates AMK-induced apoptosis in BALB/c mice cochlea. PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.

show abstract

“…Numerous in vivo and in vitro studies have demonstrated that Amikacin caused hair cell death and aberration of hearing thresholds and/or hearing levels [ 28 29 30 31 32 33 34 35 36 37 ]. In our study, group 1 (AK) had significant decreases of DPOAE amplitudes on days 7 and 15 as compared to initial DPOAE amplitudes, and our findings are compatible with relevant literature.…”

Section: Discussionmentioning

confidence: 99%

“…Studies with numerous agents were conducted in recent years in search of a prevention for amikacin-induced ototoxicity [ 28 29 30 31 32 33 34 35 36 37 ] ( Table 2 ). Research on this issue was accelerated especially during the last decade, but currently there is no agent in use (for counteracting AK's ototoxic effects) that has achieved general consensus.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats

Aksoy

Doğan

Özturan

et al. 2015

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

ObjectivesIn this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats.MethodsThirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status.ResultsThere were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group.ConclusionOur study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.

show abstract

The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs

Abstract: Hyperbaric oxygen therapy did not change the cochlear hair cell morphology or the electro-physiological thresholds of the guinea pigs given amikacin.

Cited by 8 publications

References 19 publications

Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?

Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?

FoxO3a plays a key role in the protective effects of pomegranate peel extract against amikacin-induced ototoxicity

An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats

Contact Info

Product

Resources

About