Short and long term impact of adenotonsillectomy on the immune system

Santos, Fábio Pires de Souza; Weber, Raimar; Fortes, Bibiana Callegaro; Pignatari, Shirley Shizue Nagata

doi:10.5935/1808-8694.20130006

Cited by 22 publications

(10 citation statements)

References 15 publications

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“…1B ), with predominance among the benchmarks. Our findings, however, are similar to those found by Santos et al, 9 who reported normal levels in the preoperative and postoperative periods (1 to 2 months). However, after 12 months of follow-up, the IgA and IgG levels showed significant increases.…”

Section: Discussionsupporting

confidence: 92%

“…It is associated with improved quality of life and sleep, although its causes and its effects on the immune system (e.g., reducing infections) are still controversial. 9 …”

Section: Discussionmentioning

confidence: 99%

“…The adverse impact of immune adenotonsillectomy surgery in children has been studied for years, but past reports have shown different postoperative immunoglobulin levels in the long and short term. 9 …”

Section: Discussionmentioning

confidence: 99%

“…The immunoglobulin results were compared using the Friedman test (three groups), and they showed the preoperative value of IgG ( p = 0.002) and the significant reduction of IgA ( p = 0.026). 9 …”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Microorganisms and Immunoglobulins in Children with Tonsillar Hypertrophy and Adenoiditis

Miramontes

Fagundes

Jurgielewicz

et al. 2014

Int. Arch. Otorhinolaryngol.

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Introduction: Benign idiopathic tonsillar hypertrophy (HBI) may affect a child's quality of life and sleep. Several studies have sought to relate the clinical features of HBI with the infectious and/or immunologic changes that occur. Objective: To increase the knowledge of the etiology of HBI. Data Synthesis: From 2012 to 2013 we conducted a retrospective observational study of 101 children with HBI who underwent tonsillectomies at Ambulatory ENT General Hospital of the East Zone of São Paulo City, a region with a poor socioeconomic population. Preoperative serologic results were available to confirm mononucleosis, cytomegalovirus, anti-streptolysin O (ASLO) and immunoglobulins. The mean patient age was 5.8 years (55% male, 45% female). Using the Mann-Whitney U test, we identified significant gender differences in the parameters of immunoglobulins (Ig) M (IgM), IgA, and IgE. Forty-seven percent of the patients had increased ASLO levels, and 37% had increased IgE levels. Conclusion: An evaluation of a patient's serologic parameters and laboratory results may be relevant to the etiology and prevention of HBI. Based on the results obtained from the study sample, the identification of etiologic agents and causative factors remain a public health challenge that affects the quality of life of children.

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Section: Discussionsupporting

confidence: 92%

“…It is associated with improved quality of life and sleep, although its causes and its effects on the immune system (e.g., reducing infections) are still controversial. 9 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Microorganisms and Immunoglobulins in Children with Tonsillar Hypertrophy and Adenoiditis

Miramontes

Fagundes

Jurgielewicz

et al. 2014

Int. Arch. Otorhinolaryngol.

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“…As the largest components of Waldeyer ring, [2–4] they are secondary lymphoid organs, and part of the mucosa-associated lymphoid tissue. [5,6]…”

Section: Introductionmentioning

confidence: 99%

Short- and long-term impacts of adenoidectomy with/without tonsillectomy on immune function of young children <3 years of age

Yan¹,

Song²,

Liu³

et al. 2019

Medicine

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To investigate the short- and long-term impacts of adenoidectomy with/without tonsillectomy on the immune functions of young children < 3 years of age. This longitudinal prospective study included 40 pediatric patients (age <3 y) undergoing adenoidectomy with/without tonsillectomy for snoring and sleep apnea. Serum immunoglobulin IgA, IgG, IgM, complement C3, and C4 levels were measured for the status of humoral immunity; CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD56+, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cells were measured for the status of cellular immunity. Blood samples were taken at 3 time points: before surgery, 1 month after surgery (short-term), and 3 months after surgery (long-term). All patients were assessed for short-term outcome at 1-month postoperation, but only 30 patients were followed at 3 months after surgery. The incidence of recurrent respiratory tract infections and other immune-related conditions were recorded at each follow-up. The levels of IgA significantly decreased from the preoperative level at 1-month follow-up ( P < .05), but still within normal range. No significant changes were found in the levels of IgA, IgG, IgM, C3, C4, CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD56+, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cell at 3-month follow-up in comparison with preoperative levels. There was also no episode of recurrent respiratory tract infection and other immune-deficiency conditions. Adenoidectomy with/without tonsillectomy may result in a reduction in individual antibodies in children <3 years of age, but did not show negative impacts on their immune functions. Also, the surgery does not lead to the increased risk of upper respiratory tract infection in these children.

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Toward Adenotonsillectomy in Children

Ingram

Friedman

2015

JAMA Pediatr

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Short and long term impact of adenotonsillectomy on the immune system

Abstract: This study indicated that adenotonsillectomy does not pose negative short or long term impacts upon the cellular and humoral immunity of children submitted to the procedure.

Cited by 22 publications

References 15 publications

Prevalence of Microorganisms and Immunoglobulins in Children with Tonsillar Hypertrophy and Adenoiditis

Prevalence of Microorganisms and Immunoglobulins in Children with Tonsillar Hypertrophy and Adenoiditis

Short- and long-term impacts of adenoidectomy with/without tonsillectomy on immune function of young children <3 years of age

Toward Adenotonsillectomy in Children

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