Interleukin-13 gene polymorphisms at −1055 C/T and +2044 G/A positions in patients with squamous cell carcinoma of head and neck

Khademi, Bijan; Hashemi, Seyed Basir; Ghaderi, Abbas; Shahrestani, Ali; Mohammadianpanah, Μohammad

doi:10.5935/1808-8694.20120010

Cited by 5 publications

(6 citation statements)

References 11 publications

(16 reference statements)

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“…Similarly, anti-proliferative effect of IL-13 on human solid tumors that inhibit their clonal growth and DNA synthesis is shown 46 . In contrast to this most previous studies involving this variants recorded null result for its association with different cancers such as head and neck carcinoma 47 and lung cancer 48 . Nevertheless a recent meta-analysis study suggests the possibility of IL-13+rs1800925 genotype as a risk factor for gliomas and IL-13+rs20541 contributes towards cancer 49 .…”

Section: Discussioncontrasting

confidence: 76%

Single Nucleotide Polymorphisms in IL-10, IL-12p40, and IL-13 Genes and Susceptibility to Glioma

et al. 2015

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Glioma is one of the most aggressive and most common tumors of the central nervous system (CNS) in humans. The exact causes of glioma are not well known, but evidence suggests the involvement of genetic factors in addition to environmental risk factors. The present study aimed to determine whether polymorphisms in IL-10-1082A/G, IL-12p40 1188C/A, and IL-13+2044G/A (rs20541) are associated with the incidence of glioma in Iraqi patients. Ninety-six patients with different grades of glioma and 40 apparently healthy individuals were recruited. A blood sample and genomic DNA were collected from all subjects. The amplification refractory mutation system and sequence-specific primer polymerase chain reaction (PCR) were used for genotyping of IL-10-1082A/G and IL-12p40 1188C/A, respectively; whereas, the IL-13+2044G/A was detected by DNA sequencing after amplification of the genes by PCR.All SNPs were within Hardy-Weinberg equilibrium and each appeared in three genotypes in patients and controls. In IL-10-1082A/G, these genotypes frequencies were AA (75%), AG (22.93%) and GG (2.07%) in patients as compared to similar frequencies (62.5%), (27.5%) and (10%) respectively, in controls. The variant IL-12p40 1188C/A genotype was AA (72.92%), AC (23.96%), and CC (3.13%%) in patients as compared to 65%, 30%, and 5%, respectively, in controls. The frequencies of IL-13+2044G/A genotypes (GG, GA, and AA) were 89.58%, 9.37%, and 1.04% among patients versus 47.5%, 32.5% and 20%, respectively, among controls. These results suggest a protective role of mutant alleles G and A in IL-10-1082A/G and IL-13+2044G/A against gliomas. Further studies with more rigorous parameter designs will be needed to confirm the current findings.

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Section: Discussioncontrasting

confidence: 76%

Single Nucleotide Polymorphisms in IL-10, IL-12p40, and IL-13 Genes and Susceptibility to Glioma

et al. 2015

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“…Periodontitis is a chronic inflammatory disease of the oral cavity that affects tooth-supporting tissues and alveolar bone, leading to progressive tooth loss [1][2][3] . The pathogenesis of chronic periodontitis is multifactorial, resulting from a complex interaction between pathogenic microbes, host immune responses, environmental and genetic factors.…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of chronic periodontitis is multifactorial, resulting from a complex interaction between pathogenic microbes, host immune responses, environmental and genetic factors. [3][4][5] Although bacterial infection is the primary cause in triggering periodontal disease, it's progression depends on the production of host mediators in response to bacteria and it's metabolic products. 4,6 Innate and adaptive immune reactivity control the response to periodontal pathogens 7 .…”

Section: Introductionmentioning

confidence: 99%

IL-8 as a Potential Diagnostic Salivary Biomarker in Periodontal Diseases- A Systematic Review

Chand¹,

Arora²,

Chhina³

2020

SSRN Journal

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IL-8 (chemokine) stimulate the recruitment of inflammatory cells and thus known to play a major role in the initiation and progression of any inflammation, Current systematic review aimed in finding role of salivary IL-8 as a biomarker in Periodontal Diseases, despite of having an important role in the pathogenesis of Periodontal diseases only few studies were done till date to find its co-relation with Periodontitis, Electronic searches of the PubMed, and Scopus databases were conducted from 2000 to 2016 for literature detecting IL-8 levels in individuals with CP compared with healthy individuals in the saliva of the patients. Only 5 Publications till date reported with levels of salivary Il-8 in CP, overall systematic review reported contradictory findings regarding IL-8 levels in patients with Chronic Periodontitis when compared with healthy controls, thus more number of longitudinal studies are required to conform the exact co-relation.

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“…Periodontitis is a chronic inflammatory disease of the oral cavity that affects tooth-supporting tissues and alveolar bone, leading progressively to tooth loss and can affect individual's oral health-related quality of life [1][2][3][4]. Chronic periodontitis affects nearly 50% of adult population and 60% of aged population globally, being considered the most prevalent inflammatory disease worldwide [5].…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of chronic periodontitis is multifactorial, resulting from a complex interaction between pathogenic microbes, the host immune responses, genetic and environmental factors [3,5,6,]. Although bacterial infection is the primary cause in triggering periodontal disease, it's progression depends on the production of host mediators in response to bacteria and it's metabolic products [3]. Porphyromonas gingivalis and Fusobacterium nucleatum are major culprits in periodontal destruction and are highly associated with periodontitis development [5,7].…”

Section: Introductionmentioning

confidence: 99%

Expression of Interleukin (IL)-1β, IL-8, IL-10 and IL-13 in Chronic Adult Periodontitis Progression

Et¹,

Mohor²,

D³

et al. 2017

Arch Med

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Introduction: Cytokines play a major role in the pathogenesis of periodontal disease and may be used as markers in diagnosis. We aimed to evaluate correlation between progression of periodontal disease and plasma expression of several interleukins. Material and method:A total of 88 subjects, 40 males and 48 females, divided into 4 groups: healthy group (HG), early generalized chronic periodontitis group (EGP), moderate generalized chronic periodontitis group (MGP) and advanced generalized chronic periodontitis group (AGP), were included in the study. Enzyme-linked immunosorbent assay (ELISA) test was used for quantification of interleukin (IL)-1β, IL-8, IL-10 and IL-13 in the blood samples. Clinical periodontal parameters were recorded and statistical analysis, using SPSS version 25.0, was performed.Results: Both IL-1β and IL-8 plasmatic levels were significantly higher in EGP, MGP and AGP groups compared to the control group. IL-10 and IL-13 plasma levels were significantly higher in the HG compared to chronic periodontitis groups. Significant correlations were found between IL-1β, IL-8, IL-10 and IL-13 in chronic periodontitis patients and between IL-10 and IL-13 in the control group. Conclusion:Our results suggest that interdependence between these interleukins is much more frequent in chronic periodontitis patients and that plasma concentration of each interleukin, seems to be closely associated with periodontal disease progression. A possible causal relationship between periodontal and systemic inflammation is evident.

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Interleukin-13 gene polymorphisms at −1055 C/T and +2044 G/A positions in patients with squamous cell carcinoma of head and neck

Abstract: This study suggests that there is no association between IL-13 gene polymorphisms (at position -1055C/T and +2044GI A) and susceptibility of the patients to SCC of head and neck.

Cited by 5 publications

References 11 publications

Single Nucleotide Polymorphisms in IL-10, IL-12p40, and IL-13 Genes and Susceptibility to Glioma

Single Nucleotide Polymorphisms in IL-10, IL-12p40, and IL-13 Genes and Susceptibility to Glioma

IL-8 as a Potential Diagnostic Salivary Biomarker in Periodontal Diseases- A Systematic Review

Expression of Interleukin (IL)-1β, IL-8, IL-10 and IL-13 in Chronic Adult Periodontitis Progression

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