Poultry by-products as source of collagen, nanokeratin and bioapatite for biomedical use

Souza, Francisco Fábio Pereira de; Cavalcante, Fábio Lima; Castro-Silva, Igor Iuco; Silva, André Luis Coelho da; Souza-Filho, Men de Sá Moreira de

doi:10.5935/1806-6690.20210049

Cited by 5 publications

(8 citation statements)

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“…FTIR analysis showed spectra with similar profiles between implants with the presence of chemical groups with characteristic bands of protein structures, such as collagen and nanokeratin 11 , 15 , 17 , 21 , 23 , and minerals, such as bioapatite 11 , 16 , 18 , 21 , 23 , as shown in the literature. The high similarity between the thermal behavior of the materials is directly associated with the majority presence of poultry collagen in the formulations 11 , 13 .…”

Section: Discussionsupporting

confidence: 73%

“…Interestingly, a more pronounced inflammatory response was observed for groups G3 and G4, which contained nanokeratin in their composition. It is believed that the inflammatory profile is related to the presence of nanokeratin, since the literature points out to accentuated inflammatory responses to polymeric materials 38 , 40 , including keratin extracted from chicken feathers 4 , 11 , 13 .…”

Section: Discussionmentioning

confidence: 99%

“…All fresh raw materials from Gallus gallus domesticus were derived from the broiler processing waste of a poultry industry in Fortaleza, Ceará, Brazil. Each component of the poultry hydrogels was obtained separately, following the protocol previously described by Souza et al 11 .…”

Section: Methodsmentioning

confidence: 99%

“…The poultry industry can be a source of raw material, and this reality is even more sensitive in Brazil, the second country in the world with the largest production of chicken protein, around 13 million tons per year, equivalent to the sum of all national production of beef, pork, and fish 9 . Within the context of circular economy, by-products of skin, feathers and bones could return to the production chain for the synthesis of biomaterials 9 - 11 , thus converging with the global sustainable development goals 12 .…”

Section: Introductionmentioning

confidence: 99%

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Development and characterization of poultry collagen-based hybrid hydrogels for bone regeneration

et al. 2022

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Purpose: Poultry by-products can contribute as an innovative natural source for the development of composites based on polymers and minerals aiming at bone regeneration. The objective of this study was the physicochemical and biological characterization of collagen-based hydrogels crosslinked with ultraviolet (UV)-riboflavin. Methods: Pure hydrogels of 100% collagen (G1) or hybrid hydrogels, 90% collagen:10% apatite (G2), 90% collagen:10% nanokeratin (G3), and 90% collagen:5% apatite:5% nanokeratin (G4) were characterized by scanning electron microscope, Fourier-transform infrared spectroscopy, differential scanning calorimetry, swelling degree and quali-quantitative histological analysis. Ectopic implantation in subcutaneous tissue in mice at one, three and nine weeks allowed to assess the inflammation (neutrophils, lymphocytes, macrophages, and giant cells) and repair (neovascularization, and connective tissue) to determine biocompatibility and the integrity of biomaterials to score their biodegradability. Histomorphometry on critical size defects in rat calvaria at one and three months evaluated the percentage of bone, connective tissue, and biomaterials in all groups. Results: The hydrogels presented porous microstructure, water absorption and physicochemical characteristics compatible with their polymeric and/or mineral composition. All materials exhibited biocompatibility, biodegradability, and low osteoconductivity. G2 showed greater density of new bone and biomaterial than the G1, G3 and G4. Conclusions: The collagen-apatite group formulation suggests potential for development as osteopromoting membrane.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development and characterization of poultry collagen-based hybrid hydrogels for bone regeneration

et al. 2022

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“…or polysaccharides (including chitosan, alginate, starch, and arabinoxylan, etc. ), have restricted mechanical characteristics, immunogenic prospect, and demand [10][11][12]. Poly(glycolic acid) (PGA), poly(L-lactic acid) (PLLA), and their copolymers, such as poly(DL-lactic-co-glycolic acid), are some of the most common synthetic polymers (PLGA).…”

Section: Introductionmentioning

confidence: 99%

Development of Biodegradable Bio-Based Composite for Bone Tissue Engineering: Synthesis, Characterization and In Vitro Biocompatible Evaluation

et al. 2021

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Several significant advancements in the field of bone regenerative medicine have been made in recent years. However, therapeutic options, such as bone grafts, have several drawbacks. There is a need to develop an adequate bone substitute. As a result, significant bone defects/injuries pose a severe challenge for orthopaedic and reconstructive bone tissue. We synthesized polymeric composite material from arabinoxylan (ARX), β-glucan (BG), nano-hydroxyapatite (nHAp), graphene oxide (GO), acrylic acid (AAc) through free radical polymerization and porous scaffold fabricated using the freeze-drying technique. These fabricated porous scaffolds were then coated with chitosan solution to enhance their biological activities. The complex structure of BG, nHAp, GO was studied through various characterization and biological assays. The structural, morphological, wetting and mechanical analyses were determined using FT-IR, XRD, XPS, SEM/EXD, water contact angle and UTM. The swelling (aqueous and PBS media) and degradation (PBS media) observed their behavior in contact with body fluid. The biological activities were conducted against mouse pre-osteoblast cell lines. The result found that BGH3 has desirable morphological, structural with optimum swelling, degradation, and mechanical behavior. It was also found to be cytocompatible against MC3T3-E1 cell lines. The obtained results confirmed that the fabricated polymeric scaffolds would be a potential bone substitute to regenerate defective bone with different loading bearing applications for bone tissue engineering.

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Optimization and characterization of biodegradable films from chicken gelatin crosslinked with oxidized phenolic compounds

Erge,

Güler,

Eren

2024

Food Chemistry

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Poultry by-products as source of collagen, nanokeratin and bioapatite for biomedical use

Cited by 5 publications

References 0 publications

Development and characterization of poultry collagen-based hybrid hydrogels for bone regeneration

Development and characterization of poultry collagen-based hybrid hydrogels for bone regeneration

Development of Biodegradable Bio-Based Composite for Bone Tissue Engineering: Synthesis, Characterization and In Vitro Biocompatible Evaluation

Optimization and characterization of biodegradable films from chicken gelatin crosslinked with oxidized phenolic compounds

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