New contribution to the tudy of ventricular remodeling and valve rings in dilated cardiomyopathy: anatomical and histological evaluation

Abstract

IntroductionIdiopathic dilated cardiomyopathy causes great impact but many aspects of its pathophysiology remain unknown.ObjectiveTo evaluate anatomical and histological aspects of hearts with idiopathic dilated cardiomyopathy and compare them to a control group, evaluating the behavior of the perimeters of the atrioventricular rings and ventricles and to compare the percentage of collagen and elastic fibers of the atrioventricular rings.MethodsThirteen hearts with cardiomyopathy and 13 normal hearts were analysed. They were dissected keeping the ventricular mass and atrioventricular rings, with lamination of segments 20%, 50% and 80% of the distance between the atrioventricular groove and the ventricular apex. The sections were subjected to photo scanning, with measurement of perimeters. The atrioventricular rings were dissected and measured digitally to evaluate their perimeters, later being sent to the pathology laboratory, and stained by hematoxylin-eosin, picrosirius and oxidized resorcin fuccin.ResultsRegarding to ventricles, dilation occurs in all segments in the pathological group, and the right atrioventricular ring measurement was higher in idiopathic dilated cardiomyopathy group, with no difference in the left side. With respect to collagen, both sides had lower percentage of fibers in the pathological group. With respect to the elastic fibers, there was no difference between the groups.ConclusionThere is a change in ventricular geometry in cardiomyopathy group. The left atrioventricular ring does not dilate, in spite of the fact that in both ventricles there is lowering of collagen.

Diagnostic Classification of Patients with Dilated Cardiomyopathy Using Ventricular Strain Analysis Algorithm

“…Although cardiomyocytes in DCMP are hypertrophy, the thickness of ventricular muscle wall may be normal or relatively thin due to the expansion of cardiac cavity. However, the ventricular muscle wall may also be thickened to different degrees in the early stage of the disease, which can occur at all ages, and the incidence rate in male is higher than that in female [ 4 ]. The echocardiogram images or image sequences often suffer with speckle noise, which degrades image contrast and blocks out the underlying cardiac anatomy.…”

Dilated Cardiomyopathy: Normalized Multiparametric Myocardial Strain Predicts Contractile Recovery

“…Notably, these LV geometric changes occur in an axisymmetric, circumferentially uniform distribution. [1, 2] It is therefore intuitive that the contractile injury behind these architectural changes should be manifest in a similarly uniform and homogeneous geometrical distribution. However, investigations using multiple imaging modalities to characterize regional contractile function have suggested heterogeneous contractile injury in patients with DCM.…”