Gingival carcinoma cuniculatum mimicking a reactive/inflammatory process

Is the solid variant of odontogenic keratocyst the neoplastic counterpart of the lesion?

“…Oral carcinoma cuniculatum (CC), a rare low-grade variant of squamous cell carcinoma, has been identified as an important differential diagnosis when it invades the mandible and maxilla because it lacks malignant cytological characteristics and presents some clinical, radiographic, and histopathological aspects similar to keratinizing odontogenic lesions. Histopathologically, CC presents well-differentiated squamous epithelial proliferation, with branched crypt architecture filled with keratin, a structure similar to rabbit burrows (El-Naggar et al, 2017;Silva et al, 2019). Similar to OKC, this lesion exhibits aggressive behavior and is associated with high rates of recurrence.…”