Is the solid variant of odontogenic keratocyst the neoplastic counterpart of the lesion?

Solid variant of odontogenic keratocyst in a 22‐year‐old man: Report of a case

“…Only single mutation of PTCH1 was found between nine cases and BRAF mutation was negative in all nine cases of SOCK, a mutation found in up to 90% of KA 12 . Following this, it was found that calretinin staining is positive in stellate reticulum‐like epithelium and ameloblastoma while none of SKCOT showed positive stain 9,10,12 …”

“…12 Following this, it was found that calretinin staining is positive in stellate reticulum-like epithelium and ameloblastoma while none of SKCOT showed positive stain. 9,10,12 Primary intraosseous carcinoma (PIOC) resembling keratinizing squamous cell carcinoma (SCC) is another keratinizing malignant tumor of oral cavity. These may arise de novo, from odontogenic cysts.…”

“…The lumens of cysts are filled with layers of keratin, desquamated squames, and/or necrotic material. 2 , 9 , 10 The supporting connective tissue may contain varying degrees of chronic inflammatory reactions with giant cells and thick collagen fibers. These fibers demonstrate polarization colors of greenish‐yellow range.…”

Transformation of an odontogenic keratocyst into a solid variant of odontogenic keratocyst/keratoameloblastoma during long‑term follow‑up: A case report

“…Based on these characteristics, OKC may consist of a spectrum of clinicopathological features from simple individual cysts, to cysts with multiple daughter cysts/epithelial islands, and to solid lesions recognized as true benign neoplasms. However, SOKC remains poorly defined because of unclear histopathological criteria due to the small number of reported cases ( 2 , 3 , 5 , 7 , 10 ). Given their overlapping pathological features, SOKC is difficult to distinguish from KA, a rare variant of AB with extensive keratinization in epithelial islands.…”

“…The diagnostic differences between KA and SOKC are the stellate reticulum-like appearance of focal areas, subnuclear vacuolization of basal cells and lamellated-type central keratinization, which are characteristic of KA ( 11 ). However, a lesion with histological features resembling those of both SOKC and KA has been reported under the name of SOKC with ameloblastomatous transformation ( 7 ), and SOKC and KA may fall into a similar histological spectrum of odontogenic tumors. Ide et al ( 10 ) also suggested that SOKC and KA share a histogenetic relationship and form a clinicopathological spectrum, indicating that they should not necessarily be separated into different entities.…”