Thrombotic thrombocytopenic purpura: a case report

Drumond, João Paulo Nunes; Abou-Arabi, Rima M.; Figueiredo, Raissa P. C.; Mourão, Vanessa N.; Aiziro, Juliana B.; Caly, Décio N.; Cortez, Afonso José Pereira

doi:10.5935/1676-2444.20180045

Cited by 2 publications

(2 citation statements)

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“…The literature does not provide a treatment time, however, therapy should be continued until the platelet count reaches 100,000/mm 3 and the LDH levels fall below 400 U/l, as these are the most sensitive markers for assessing therapeutic response [ 9 ]. In both of our cases, platelet counts increased to above 150,000/mm 3 for two days after which plasmapheresis was halted, although LDH levels showed an increasing trend immediately after plasmapheresis was stopped and later showed a downward trend.…”

Section: Discussionmentioning

confidence: 99%

Thrombotic Thrombocytopenic Purpura: A Tale of Two Cases

Ghogale¹,

Pandey²,

Praveen³

et al. 2022

Cureus

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Microangiopathic hemolytic anaemia, thrombocytopenia, renal failure, neurologic abnormalities, and fever form the pentad of thrombotic thrombocytopenic purpura (TTP). Early diagnosis is crucial because TTP responds well to plasmapheresis therapy but is associated with substantial mortality if left untreated. A substantial percentage of patients with TTP used to die from systemic microvascular thrombosis in the brain and the heart. However, since plasma exchange therapy became a mainstay in the treatment of TTP, mortality has reduced considerably. Diagnosing TTP can be difficult due to the vast range of symptoms and the absence of clearly defined diagnostic criteria. Hemolytic uremic syndrome and disseminated intravascular coagulation are a close differential of TTP. Here we report two patients with TTP who achieved remission when treated with steroids, plasmapheresis and were free of disease relapse till about two months during follow-up in the outpatient department.

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Section: Discussionmentioning

confidence: 99%

Thrombotic Thrombocytopenic Purpura: A Tale of Two Cases

Ghogale¹,

Pandey²,

Praveen³

et al. 2022

Cureus

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“…Treatment options for TTP are plasmapharesis, FFP transfusion, steroids and immunosuppression. 6 All these treatment options were used in our patient.…”

Section: Discussionmentioning

confidence: 99%

Churg Strauss Syndrome â€“ Case Report

Noreen¹,

Amanat²,

Jalil³

et al. 2022

Ann Pak Inst Med Sci

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We report a 49 year old male patient who presented with swelling in both thighs without pain and dyspnea. Platelet count was low (13,000/mm3) with increased eosinophils (48.9%). Patient developed pulmonary embolism. His ADAMTS 13 level was low and was therefore diagnosed as TTP. Treatment given was corticosteroid and plasma exchange. After a year he developed a lump in the skull. Histopathology report revealed vasculitis. Due to presence of vasculitis (TTP) along with eosinophilia, patient was finally diagnosed as a case of Churg Strauss Syndrome (CSS).

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Thrombotic thrombocytopenic purpura: a case report

Cited by 2 publications

References 0 publications

Thrombotic Thrombocytopenic Purpura: A Tale of Two Cases

Thrombotic Thrombocytopenic Purpura: A Tale of Two Cases

Churg Strauss Syndrome â€“ Case Report

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