Predominant overexpression of CD25/FOXP3, IFN-γ, and suppressive cytokines in high-grade lesion samples infected with human papillomavirus

Bonin, Camila Mareti; Padovani, Cacilda Tezelli Junqueira; Ferreira, Alda Maria Teixeira; Ávila, Leandro S.; Machado, Ana Paula; Prata, Thiago Theodoro Martins; Fernandes, Carlos Eurico dos Santos; Tozetti, Inês Aparecida

doi:10.5935/1676-2444.20170004

Cited by 4 publications

(6 citation statements)

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“…However, the number of T cell populations within HPV-positive high grade CINs may not be different [119] . Further, despite the effector role of IFN-γ in antitumor immune response, there is increasing evidence that chronic IFN-γ release could promote immune suppression by upregulation of immunomodulatory signals such as PD-L1 and IDO in HPV-positive precancerous lesions [127] . Adding to the complexity of the role of IFN-γ, IFN-γ can be produced by a variety of cells, which, in combination with different tissue microenvironments, can cause different outcomes to the immune response.…”

Section: Chronic Hpv Infection Immunoregulatory Cytokine Milieu and mentioning

confidence: 99%

Modulation of antigen presenting cell functions during chronic HPV infection

Bashaw

Leggatt

Chandra

et al. 2017

Papillomavirus Research

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High-risk human papillomaviruses (HR-HPV) infect basal keratinocytes, where in some individuals they evade host immune responses and persist. Persistent HR-HPV infection of the cervix causes precancerous neoplasia that can eventuate in cervical cancer. Dendritic cells (DCs) are efficient in priming/cross-priming antigen-specific T cells and generating antiviral and antitumor cytotoxic CD8+ T cells. However, HR-HPV have adopted various immunosuppressive strategies, with modulation of DC function crucial to escape from the host adaptive immune response. HPV E6 and E7 oncoproteins alter recruitment and localization of epidermal DCs, while soluble regulatory factors derived from HPV-induced hyperplastic epithelium change DC development and influence initiation of specific cellular immune responses. This review focuses on current evidence for HR-HPV manipulation of antigen presentation in dendritic cells and escape from host immunity.

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Section: Chronic Hpv Infection Immunoregulatory Cytokine Milieu and mentioning

confidence: 99%

Modulation of antigen presenting cell functions during chronic HPV infection

Bashaw

Leggatt

Chandra

et al. 2017

Papillomavirus Research

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“…The expression of FOXC2 in patients with HPV-positive cervical cancer was higher than patients with HPVnegative cervical cancer (Wang and Yue, 2017) FOXP3 Overexpressed CD25/FOXP3 in high-grade cervical intraepithelial neoplasia (CIN2/3) infected with HPV (Bonin et al, 2017;Scott et al, 2009) FOXP3 Upregulation of FOXP3 Expression during progression of CINs and invasive squamous cell carcinomas (ISCCs) is significantly linked to the expression of P16 INK4a…”

Section: Foxc2mentioning

confidence: 99%

“…Wang & Yue, 2017). Overexpression of CD25/FOXP3 in high-grade CIN (CIN2/3) infected with HPV is associated with the persistence of a high-risk HPV infection, promotes local immunosuppression, and facilitates lesion progression to cervical cancer (Bonin et al, 2017;Scott, Ma, Kuzmich, & Moscicki, 2009). Upregulation of FOXP3 expression during the progression of CINs and invasive squamous cell carcinomas is significantly linked to the expression of P16 INK4a , a critical marker of HPV integration into host cells.…”

Section: Human Papilloma Virusmentioning

confidence: 99%

The roles of FOX proteins in virus‐associated cancers

Ramezani

Nikravesh

Faghihloo

2018

Journal Cellular Physiology

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Forkhead box (FOX) proteins play a crucial role in regulating the expression of genes involved in multiple biological processes, such as metabolism, development, differentiation, proliferation, apoptosis, migration, invasion, and longevity. Deregulation of FOX proteins is commonly associated with cancer initiation, progression, and chemotherapeutic drug resistance in many human tumors. FOX proteins deregulate through genetic events and the perturbation of posttranslational modification. The purpose of the present review is to describe the deregulation of FOX proteins by oncoviruses. Oncoviruses utilize various mechanisms to deregulate FOX proteins, including alterations in posttranslational modifications, cellular localization independently of posttranslational modifications, virus-encoded miRNAs, activation or suppression of a series of cell signaling pathways. This deregulation can affect proliferation, metastasis, chemotherapy resistance, and immunosuppression in virus-induced cancers and help to chronic viral infection, development of gluconeogenic responses, and inflammation. Since the PI3K/ Akt/mTOR signaling pathway is the upstream FOXO, suppressing it can cause FOXO function to return, and this can be one of the reasons for patients to recover from the infection of the viruses used to treat these inhibitors. Hence, FOX proteins could serve as prognosis markers and target therapy specifically in cancers caused by oncoviruses.

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“…A related study of cervical cancer found that large numbers of CD4 and CD25 cells were recruited by T reg cells in the blood of patients with high-grade squamous intraepithelial lesions ( 16 ). The T reg cell numbers in the blood of the cervical cancer and CIN patients were significantly higher than that in the control patients ( 11 ).…”

Section: T-cell Subsets and Cervical Cancermentioning

confidence: 99%

A review of the research progress in T-lymphocyte immunity and cervical cancer

Zhang¹,

Mao²,

Lai³

et al. 2020

Transl Cancer Res TCR

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Cervical cancer develops as a result of T-cell immune evasion by human papillomavirus (HPV).T-cell immunity requires the participation of many factors, such as antigen-presenting cells (APCs), cytokines, co-stimulatory molecules, etc. HPV vaccines are promising treatments to prevent HPV infection and cervical cancer. This article mainly provides a summary of the number and function changes of T cells during HPV infection and cervical cancer development. Studies on t-cell immunotherapy, which is expected to become a new treatment for cervical cancer after surgery, radiotherapy, and chemotherapy, are also reviewed in this article.

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Predominant overexpression of CD25/FOXP3, IFN-γ, and suppressive cytokines in high-grade lesion samples infected with human papillomavirus

Cited by 4 publications

References 0 publications

Modulation of antigen presenting cell functions during chronic HPV infection

Modulation of antigen presenting cell functions during chronic HPV infection

The roles of FOX proteins in virus‐associated cancers

A review of the research progress in T-lymphocyte immunity and cervical cancer

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