Sepsis-associated organ dysfunction and increased supportive care are associated
            with high serum interleukin-6 levels

Carta, Adriana; Lucca, Maria Gabriela de; Pires, Milton Dorival; Lobo, Suzana Margareth

doi:10.5935/1676-2444.20160060

Cited by 2 publications

(4 citation statements)

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“…The results demonstrated significant decline of IL-6 at 48 h after the pharmacotherapy of systemic infection compared with their initially high levels at the at the time of admission to the intensive care unit (Table 1). These observations may be confirmed with other reports [15,17,[34][35][36][37][38]. In the case of patients with septic shock, the levels of IL-6 in blood serum remained high during the first 48 h after admission to the ICU (70.0 pg/mL at admission; 50.0 pg/mL at 48 h), compared to septic patients (60.0 pg/mL at admission; 7.0 pg/mL at 48 h), this may indicate additional anti-inflammatory mechanisms involved in the course of infection, perhaps due to increased damage of the endothelium in patients with septic shock.…”

Section: Discussionsupporting

confidence: 93%

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Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Vivas

Guerrero

Tascón

et al. 2021

IMAS

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In this study, IL-6 levels were assessed as inflammatory biomarker of bacterial sepsis in patients hospitalized at the ICU of the hospital of Colombia.Materials and methodsProspective study on 62 patients diagnosed with sepsis and septic shock. An ELISA assay was used to test serum levels of IL-6 at admission and 48 h after admission. Variables were analyzed by χ2 test (alfa <0.05). Multivariable Cox regression was used to determine the survival with the statistical program SPSS v23.00.ResultsPatient's median age was 53 years old and 59.7% were male. Lung was the most common primary site of infection (43.5%), and hypertension comorbidity with higher prevalence (40%). Infection by Gram negative bacteria were significantly more frequent among patients than Gram positive (P = 0.037). Overall, survival analysis showed that 10 (16.1%) patients died with a survival median of 7.00 +4.874 (2–3) days. In patients with sepsis we detected a significant decline in the average of IL-6 serum levels after 48 h of admission [7.50 (SD: 7.00–68.00) pg/mL vs. 68.00 [SD: 7.00–300.00] pg/mL (P = 0.000). Only 25% of patients with septic shock who presented high levels of IL-6 at the time of admission and at 48 h had a survival up to 15 days (P = 0.005).ConclusionWe found significant differences between the plasma levels of IL-6 during the first 48 h after admission to the ICU among patients with sepsis and septic shock. Patients with sepsis had a significant decline in IL-6 levels, whereas in patients who developed septic shock, levels of this cytokine remained high and have a lower survival compared to those who maintained low levels of IL-6.

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Section: Discussionsupporting

confidence: 93%

“…Studies suggest that serum levels of IL-6 in patients with sepsis are elevated in non-survivors and are associated with early mortality [35][36][37][38]. In our study we did not find a significant correlation between serum levels of IL-6 and sepsis outcome in terms of mortality.…”

Section: Discussioncontrasting

confidence: 77%

Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Vivas

Guerrero

Tascón

et al. 2021

IMAS

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“…The early-onset activation of innate immune cells after infection releases proinflammatory cytokines that further mediate responses in the target tissues and in adaptive immune cells like lymphocytes (3). In this context, proinflammatory cytokines, like IL-1 β and IL-6, seem to exert a primary role in mediating (4) autocrine and paracrine signaling, with reflections on biosynthetic pathways (5)(6)(7)(8)(9). For instance, an increase in IL-6 stimulates the liver synthesis of reactant C-reactive protein (CRP), a pro-and anti-inflammatory effector (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the onset of inflammatory response, termination, and transition to the homeostasis after sepsis are ATP demanding processes and require biosynthetic precursors provided by metabolic pathways. While studies have shown that an altered inflammatory response in the acute and prolonged phases of sepsis is tightly connected with impaired immune cells metabolism and unfavorable outcomes, the mechanistic mediators of this misconnection are not completely elucidated yet (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Short-Term Inflammatory Biomarker Profiles Are Associated With Deficient Mitochondrial Bioenergetics in Lymphocytes of Septic Shock Patients—a Prospective Cohort Study

Nedel¹,

Strogulski

Rodolphi

et al. 2022

Shock

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Introduction: A biomarker strategy based on the quantification of an immune profile could provide a clinical understanding of the inflammatory state in patients with sepsis and its potential implications for the bioenergetic state of lymphocytes, whose metabolism is associated with altered outcomes in sepsis. The objective of this study is to investigate the association between mitochondrial respiratory states and inflammatory biomarkers in patients with septic shock. Methods: This prospective cohort study included patients with septic shock. Routine, complex I, complex II respiration, and biochemical coupling efficiency were measured to evaluate mitochondrial activity. We measured IL-1ß, IL-6, IL-10, total lymphocyte count, and C-reactive protein levels on days 1 and 3 of septic shock management as well as mitochondrial variables. The variability of these measurements was evaluated using delta counts (days 3–1 counts). Results: Sixty-four patients were included in this analysis. There was a negative correlation between complex II respiration and IL-1ß (Spearman ρ, −0.275; P = 0.028). Biochemical coupling efficiency at day 1 was negative correlated with IL-6: Spearman ρ, −0.247; P = 0.05. Delta complex II respiration was negatively correlated with delta IL-6 (Spearman ρ, −0.261; P = 0.042). Delta complex I respiration was negatively correlated with delta IL-6 (Spearman ρ, −0.346; P = 0.006), and delta routine respiration was also negatively correlated with both delta IL-10 (Spearman ρ, −0.257; P = 0.046) and delta IL-6 (Spearman ρ, −0.32; P = 0.012). Conclusions: The metabolic change observed in mitochondrial complex I and complex II of lymphocytes is associated with a decrease in IL-6 levels, which can signal a decrease in global inflammatory activity.

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Sepsis-associated organ dysfunction and increased supportive care are associated with high serum interleukin-6 levels

Cited by 2 publications

References 0 publications

Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Short-Term Inflammatory Biomarker Profiles Are Associated With Deficient Mitochondrial Bioenergetics in Lymphocytes of Septic Shock Patients—a Prospective Cohort Study

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