Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Abstract

In this study, IL-6 levels were assessed as inflammatory biomarker of bacterial sepsis in patients hospitalized at the ICU of the hospital of Colombia.Materials and methodsProspective study on 62 patients diagnosed with sepsis and septic shock. An ELISA assay was used to test serum levels of IL-6 at admission and 48 h after admission. Variables were analyzed by χ2 test (alfa <0.05). Multivariable Cox regression was used to determine the survival with the statistical program SPSS v23.00.ResultsPatient's median age was 53 years old and 59.7% were male. Lung was the most common primary site of infection (43.5%), and hypertension comorbidity with higher prevalence (40%). Infection by Gram negative bacteria were significantly more frequent among patients than Gram positive (P = 0.037). Overall, survival analysis showed that 10 (16.1%) patients died with a survival median of 7.00 +4.874 (2–3) days. In patients with sepsis we detected a significant decline in the average of IL-6 serum levels after 48 h of admission [7.50 (SD: 7.00–68.00) pg/mL vs. 68.00 [SD: 7.00–300.00] pg/mL (P = 0.000). Only 25% of patients with septic shock who presented high levels of IL-6 at the time of admission and at 48 h had a survival up to 15 days (P = 0.005).ConclusionWe found significant differences between the plasma levels of IL-6 during the first 48 h after admission to the ICU among patients with sepsis and septic shock. Patients with sepsis had a significant decline in IL-6 levels, whereas in patients who developed septic shock, levels of this cytokine remained high and have a lower survival compared to those who maintained low levels of IL-6.

A Secondary Retrospective Analysis of the Predictive Value of Activated Neutrophils (NEUT-RI) in Septic and Non-septic Patients in Intensive Care

“…Additionally, it would be valuable to correlate the insights derived from NEUT-RI with IL-6 levels for early sepsis diagnosis. As indicated in the literature, IL-6 plays a pivotal role in determining the prognosis of patients in the ICU [32]. Integrating IL-6 data with the previously obtained information on NEUT-RI and PCT has the potential to enhance the specificity and/or sensitivity of the outcome, offering a more comprehensive understanding.…”

Fermented Sprouts of Codonopsis lanceolata Suppress LPS-Induced Inflammatory Responses by Inhibiting NF-κB Signaling Pathway in RAW 264.7 Macrophages and CD1 Mice

“…Especially, plasma levels of IL-6 are considered an important biomarker positively associated with septic shock in patients. Furthermore, patients who exhibit elevated levels of IL-6 have a lower survival rate than those with lower levels, prompting studies that aim to develop therapeutic agents such as anti-IL-6 antibodies [ 67 , 68 , 69 ]. The effectiveness of F-CSA in treating sepsis was evaluated using an LPS-induced mouse model in this study.…”

Fieber in der Intensivmedizin

“…Damit ist die Kinetik von Interleukin-6 deutlich schneller als beim CRP und PCT, die eine "Response"-Halbwertszeit von 6-8 h bis zum Anstieg aufweisen [30]. Darüber hinaus kann IL-6 zur Prognoseabschätzung genutzt werden [30,31].…”