Influence of hemodialysis on the plasma concentration of adenosine deaminase in patients with chronic kidney disease

Chielle, Eduardo O.; Rigon, Kaue A.; Arcari, Idania A.; Stein, Vanessa; Santos, Gelson Antônio dos

doi:10.5935/1676-2444.20150026

Cited by 7 publications

(11 citation statements)

References 7 publications

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“…Earlier data showed to patients ESRD before dialysis sera ADH, urea and creatinine levels are higher than healthy control. Previous studies, agree with data to ADH, urea and creatinine levels [14][15][16]. subsequent data confirm this finding and indicated that the elevated levels of ADH were related to osmolality due to increased concentration of salts and proteins in the blood increases the storage of water in the body and thus leads to lower kidney function and increased secretion of ADH.…”

Section: Resultssupporting

confidence: 88%

Study of the Anti-Diuretic Hormone (ADH) on End Stage Renal Failure Disease (ESRD) Pre-Hemodialysis in Iraqi Patients

Al-Taiee¹,

Al-Shammaa²,

Aljber³

2019

IHJPAS

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Chronic renal disease (CRD) is a pathophysiologic process with multiple etiologies, resulting in the inexorable attrition of Nephron number and function and frequently leading to end-stage renal disease (ESRD). In turn, ESRD represents a clinical state or condition in which there has been an irreversible loss of endogenous renal function, of a degree sufficient to render the patient permanently dependent upon renal replacement therapy (dialysis of transplantation) in order to avoid life threatening uremia, reflecting a dysfunction of all organ systems as a result of untreated or under treated acute or chronic renal failure. The current study was involved 80 patients, the age range within 25-70 years, selected sample of patients who attend Iraqi center of kidney dialysis, Baghdad Teaching Hospital and Al-Yarmok Teaching Hospital. All the patient's body mass index [BMI] were measured serum anti diuretic hormone ADH was assessed using enzyme linked immunosorbent kit [Elisa] while urea, creatinine, albumin, hemoglobin were determined by spectrophotometer (PD-303), and sodium, potassium, chloride were determined by Electrolyte analyzer 9180.These patients were divided in two group B (40 patients) as pre dialysis with ESRD, and group A (40) healthy control. Results showed non-significant elevations in ADH levels in the patient group compared with the control group, while highly significant increase in urea, creatinine and albumin levels in in the patient group compared with the control group, also highly significant decrease in hemoglobin comparing with the control group. Also, it was observed non-significant decrease in sodium, non-significant increase in potassium and highly significant increase in chloride when comparing with the control group.

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Section: Resultssupporting

confidence: 88%

Study of the Anti-Diuretic Hormone (ADH) on End Stage Renal Failure Disease (ESRD) Pre-Hemodialysis in Iraqi Patients

Al-Taiee¹,

Al-Shammaa²,

Aljber³

2019

IHJPAS

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“…All obtained laboratory values are represented in table 1. These results had become axiom in the literatures [3,14]. In CRF, the increased serum urea level is proportional to the progression of the disease, but it is highly influenced by a catabolic state or an excessive protein ingestion, leading to a higher production of other waste substances of protein catabolism while the increase in Cr level in the serum of patients with CRF is attributed to the decrease in the number of functioning nephrons [12,14].…”

Section: Resultsmentioning

confidence: 99%

“…Kidney diseases are a public health problem worldwide. In Iraq, over recent years, there has been a significant rise in the number of patients with chronic renal failure (CRF), where there is increased number of patients The renal failure refers to a condition where the kidneys lose their normal function due to various factors resulting accumulation of waste and toxic materials inside the body such as urea and creatinine (Cr), therefore tests of urea and Cr are sufficient tests to evaluate whether a patient is suffering kidney disease, in addition to follow-up of control and treatment of this disease [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…The kidneys play an essential role in calcium metabolism and patients with CKD have low blood calcium levels [12]. It is worth to be mentioned that few previous studies which interested ADA in renal failure patients but they never enlighten a correlation of ADA and calcium [3,6]. The objective of this study is trying to find early diagnostic tool for this disease and monitor steps of treatment via investigation whether adenosine deaminase (ADA) activity has any correlation with calcium concentration in patients with (CRF) for the first time.…”

Section: Introductionmentioning

confidence: 99%

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A Correlation of Adenosine Deaminase Activity with Calcium Concentration in Sera of Renal Failure Patients

Issmer

2019

University of Thi-Qar Journal

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Chronic renal failure (CRF) is one of the major public health problems in Iraq. This work aimed to investigate whether adenosine deaminase (ADA) activity has any correlation with calcium concentration in patients with CRF for the first time, then using this correlation as a diagnostic tool for CRF disease. Creatinine (Cr), urea, total protein concentrations, in addition to ADA activity and calcium concentration, were measured for 33 males individuals divided to two groups, the first group included eighteen patients with CRF before hemodialysis at department of artificial kidney of Al-Hussein Teaching Hospital in Thi-Qar (Iraq) while control group included fifteen healthy matched individuals. The results showed that a significant increase in Cr, urea concentrations in addition to ADA activity, while there was a significant decrease in a total protein and calcium concentrations for patients group comprised with control group (p < 0.05). Indeed, there was a weak negative correlation between ADA activity and calcium concentration according to this study.

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“…The ADA enzyme is widely distributed in tissues and plays a vital role in a numerous physiological systems. However, studies have reported that ADA activity could be used to monitor inflammation in patients with CKD [ 19 ]. Also, increased ADA positively correlates with oxidative stress [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Suppression of Adenosine Deaminase and Xanthine Oxidase Activities by Mineralocorticoid and Glucocorticoid Receptor Blockades Restores Renal Antioxidative Barrier in Oral Contraceptive-Treated Dam

Badmus

Areola

Benjamin

et al. 2021

J Renin Angiotensin Aldosterone Syst

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Objective. We tested the hypothesis that postpartum combined oral contraceptive (COC) treatment would induce oxidative stress via the adenosine deaminase-xanthine oxidase pathway in the kidney. We also sought to determine whether mineralocorticoid receptor (MR) or glucocorticoid receptor (GR ) blockade would suppress the activities of ADA and xanthine oxidase caused by postpartum COC treatment in the kidney. Methods. Twenty-four Wistar dams were randomly assigned to 4 groups ( n = 6 / group ). Dams received vehicle (po), COC (1.0 μg ethinylestradiol and 5.0 μg levonorgestrel; po), COC with GR blockade (mifepristone; 80.0 mg/kg; po), and COC with MR blockade (spironolactone; 0.25 mg/kg; po) daily between 3rd and 11th week postpartum. Results. Data showed that postpartum COC caused increased plasma creatinine and urea, increased renal triglyceride/high-density lipoprotein ratio, free fatty acid accumulation, alanine aminotransferase, gamma-glutamyltransferase, uric acid, and activities of renal XO and ADA. On the other hand, postpartum COC resulted in decreased plasma albumin, renal glutathione, and Na+-K+-ATPase activity with no effect on lactate production. However, MR or GR blockade ameliorated the alterations induced by postpartum COC treatment. The present results demonstrate that MR or GR blockade ameliorates postpartum COC-induced increased activities of ADA and xanthine oxidase and restores glutathione-dependent antioxidative defense. Conclusion. These findings implicate the involvements of GR and MR in renal dysfunctions caused by COC in dams via disrupted glutathione antioxidative barrier.

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Influence of hemodialysis on the plasma concentration of adenosine deaminase in patients with chronic kidney disease

Cited by 7 publications

References 7 publications

Study of the Anti-Diuretic Hormone (ADH) on End Stage Renal Failure Disease (ESRD) Pre-Hemodialysis in Iraqi Patients

Study of the Anti-Diuretic Hormone (ADH) on End Stage Renal Failure Disease (ESRD) Pre-Hemodialysis in Iraqi Patients

A Correlation of Adenosine Deaminase Activity with Calcium Concentration in Sera of Renal Failure Patients

Suppression of Adenosine Deaminase and Xanthine Oxidase Activities by Mineralocorticoid and Glucocorticoid Receptor Blockades Restores Renal Antioxidative Barrier in Oral Contraceptive-Treated Dam

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