A Correlation of Adenosine Deaminase Activity with Calcium Concentration in Sera of Renal Failure Patients

Abstract

Chronic renal failure (CRF) is one of the major public health problems in Iraq. This work aimed to investigate whether adenosine deaminase (ADA) activity has any correlation with calcium concentration in patients with CRF for the first time, then using this correlation as a diagnostic tool for CRF disease. Creatinine (Cr), urea, total protein concentrations, in addition to ADA activity and calcium concentration, were measured for 33 males individuals divided to two groups, the first group included eighteen patients with CRF before hemodialysis at department of artificial kidney of Al-Hussein Teaching Hospital in Thi-Qar (Iraq) while control group included fifteen healthy matched individuals. The results showed that a significant increase in Cr, urea concentrations in addition to ADA activity, while there was a significant decrease in a total protein and calcium concentrations for patients group comprised with control group (p < 0.05). Indeed, there was a weak negative correlation between ADA activity and calcium concentration according to this study.