Osseous metaplasia in gliosarcoma: an unusual histologic finding. Case report

Abstract

Gliosarcoma (GS) is a malignant neoplasm of the central nervous system that has coexisting glial and mesenchymal components. GSs are rarely related to osseous metaplasia. The authors report a case of GS in a male patient presenting apathy and catatonia. Computed tomography/magnetic resonance imaging showed an expansive process affecting the left frontal lobe. At microscopy, a malignant glioma constituted by highly atypical glial cells intermingled with spindle-shaped cells was identified. The lesion showed areas of necrosis with pseudopalisading formation, focus of osseous metaplasia, and positive immunoexpression of S100, CD99 and vimentin in both elements. Only the sarcomatous component exhibited negative immunoexpression of glial fibrillary acidic protein (GFAP). The diagnosis of GS was then established.

As Tecnologias na Educação: (re)pensando seus sentidos tecnopoiéticos

“…Nessa complexidade das dimensões da emotividade humana há uma relação contínua com as formas do sujeito se expressar, o que pode despertar um novo estado de espírito e a sensação de reconhecimento e pertencimento. Alguns estudos abordados nesse trabalho seguiram essa linha de investigação, já outros buscaram a partir desse conhecimento, propor estilos e estratégias de aprendizagem, de forma mais racionalizada e construtivista -a partir das significações e construções do conhecimento, de modo que no AVA o estudante vivencia experiências sociais e afetivas, que podem ser estimuladas por meio de atividades cooperativas e em redes sociais (ANTUNES, 2016;CAMBRUZZI, 2014;GOMES, 2012;KAMPFF, 2009;PORTAL, 2016;QUEIROGA, 2007;SILVA e SILVA, 2015).…”

Gliosarcoma with Complete Osteosarcomatous Differentiation and Extensive Calcification: Case Report

“…We report a case of dystrophic calcification and stone formation in a patient with gliosarcoma, a topic that has been scarcely reported. There has only been one report of a gliosarcoma with osteosarcomatous differentiation [3], compared to the others that have described osseous metaplasia [8,[15][16][17]. The extracellular fluids are supersaturated with calcium phosphate, but inhibitors such as matrix gla protein, osteoconectin and osteoponin prevent crystal deposition under normal physiological conditions [18].…”