Adherence of men living with HIV/AIDS to antiretroviral treatment

Moraes, Danielle Chianca de Andrade; Oliveira, Regina Célia de; Costa, Solange Fátima Geraldo da

doi:10.5935/1414-8145.20140096

Cited by 10 publications

(10 citation statements)

References 6 publications

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“…However, survival rates did not differ between men and women17. Another study showed that men had less adherence in taking ART medication18. A study in India did not find a significant relationship between gender and drug adherence, which could be due to small sample size15.…”

Section: Discussionmentioning

confidence: 96%

Non- adherence to anti-retroviral medication in Shiraz, 2014: a cross sectional study

2018

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BackgroundMedication adherence is a dynamic and complex behavioral process, which is strongly influenced by personal, social and environmental factors.ObjectivesTo determine the prevalence and factors affecting non-adherence to medication among HIV-infected patients.Methods and materialsDesignA cross-sectional study.SettingVoluntary Counseling and Testing Center (VCT), Shiraz, Fars province, in the South of Iran.PatientsAmong HIV-positive patients who received anti-retroviral therapy, 214 adult patients were selected through convenience sampling. Their medication adherence was checked by interview and counting the pills on visits during two months. Clinical and laboratory data were obtained from the patients' records.ResultsNon-adherence and adherence groups included 30.4% (65) and 69.6% (149) of the patients, respectively. The mean age of patients was 40.80±7.77 years, and ranged from 20 to 65 years. Majority of cases (65%) were male. A significant relationship was found between non-adherence to medications and the variables of transmission method, marital status, housing status, and CD4, but there was no significant relationship with gender.ConclusionThe prevalence of medication adherence was similar to other regions with limited financial resources. To increase patient's medication adherence, they should be exposed to motivational interventions to promote their drug consumption, social and occupational support.

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Section: Discussionmentioning

confidence: 96%

Non- adherence to anti-retroviral medication in Shiraz, 2014: a cross sectional study

2018

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“…However, a study in Rio de Janeiro that specifically involved a male population (the predominant gender in the current study) mentions that in cases where serological status is undisclosed, having more persons residing in the same household can hinder regular taking of medications 19 . This finding could explain the higher retention of single and separated males and widowers in the model, considering the likelihood of these individuals living with fewer persons in the household and the close relationship between ART adherence and retention in care.…”

Section: Discussionmentioning

confidence: 83%

“…According to the study, the use of four or more pills a day contributed to retention in care. Reporting on the interrelationship between ART and retention in care, as mentioned previously, this finding contradicts some studies that suggest that the more medications in the treatment regimen, the lower the adherence and thus the lower the retention in care 8,19,22 .…”

Section: Classification Of Decision Tree Totalmentioning

confidence: 81%

Modelo preditivo de retenção no cuidado especializado em HIV/aids

et al. 2018

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O estabelecimento de metas universais voltadas ao controle do HIV/aids e a instituição do tratamento como forma de prevenção reforçam a necessidade do acompanhamento clínico continuado das pessoas vivendo com HIV/aids como um elemento indispensável ao cuidado destas, sendo a retenção no cuidado em saúde uma necessidade e um desafio. Neste estudo, objetivou-se construir um modelo preditivo de retenção de pessoas vivendo com HIV/aids no cuidado em saúde. Para tanto foi construído um modelo estatístico, árvore de decisão, com base em variáveis sociodemográficas, clínicas e relacionadas aos comportamentos em saúde, identificadas em um banco de dados que contemplava informações de 260 pessoas com HIV/aids, vinculadas a um serviço especializado no atendimento a estes indivíduos. O modelo subsidiou a identificação de nove variáveis cujos ganhos de informação foram significativos em relação à variável desfecho, provável retenção no cuidado em saúde, e à construção de 24 regras de decisão, dando origem a uma árvore com porcentual de acerto de 80,4%, as quais poderão contribuir com a identificação de possíveis estratégias no sentido de otimizar a retenção e contribuir com o alcance das metas propostas para o enfrentamento da epidemia nos próximos anos.

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“…The importance of ARV treatment in HIV infected persons is massive as it prolongs their survival, advances their value of life and minimizes the morbidity and mortality rates [ 18 ]. ARV treatment is the standard care for all HIV infected persons in Kenya [ 19 ]. However, there is a contest due to HIV drug-resistant mutations which weakens effectiveness of the drug.…”

Section: Discussionmentioning

confidence: 99%

Correlation of HIV-1 drug resistant mutations and virologic failure

Makwaga¹,

Mulama²,

John³

et al. 2021

Pan Afr Med J

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Introduction mutations are important by ensuring that the HIV-1 agent remains fit in the environment and evades drugs that are developed purposely to kill them. In Kenya, mutations conferring resistance to available ARVs have been reported in previous studies. However, there is a paucity of information on whether these previous studies have reported all mutations conclusively that confer resistance to available drugs leading to virologic failure. Therefore, this study was sought to identify the current HIV-1 drug-resistant mutations attributable to virologic failure among adults on various ARV regimens. Methods the samples were collected March to June 2020. Analysis of viral loads and HIV-1 drug-resistant mutations through sequencing of the pol region of HIV-1 were done. Alignment of the cDNA sequences was done by Recall (beta version 3.05) software. HIV-1 resistant mutations were identified by Stanford University HIV drug resistance database. Results most of the participants had viral loads of more than 1000 copies/ml during all the three visits. Out of 125 mutations identified, 83 mutations resulted in virologic failure. Out of 17 new mutations, 14 resulted in virologic failure and included NRTIs (L74I, L74V, T69D, V65R); NNRTIs (A98G, V179E, V179F, V179D, 179F); PIs (I54V3, F53L2, L89T, G48A). Conclusion the study reveals new HIV-1 drug-resistant mutations which have never been reported in Kenya as well as old and both resulted in virologic failure. This calls for frequent monitoring and profiling of mutations that will enable decision-making in the drugs and vaccine design and development.

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Adherence of men living with HIV/AIDS to antiretroviral treatment

Cited by 10 publications

References 6 publications

Non- adherence to anti-retroviral medication in Shiraz, 2014: a cross sectional study

Non- adherence to anti-retroviral medication in Shiraz, 2014: a cross sectional study

Modelo preditivo de retenção no cuidado especializado em HIV/aids

Correlation of HIV-1 drug resistant mutations and virologic failure

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