Non- adherence to anti-retroviral medication in Shiraz, 2014: a cross sectional study

Motazedian, Nasrin; Sayadi, Mehrab; Firoozbakhtian, Ali

doi:10.4314/ahs.v18i2.24

Cited by 10 publications

(14 citation statements)

References 23 publications

(25 reference statements)

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“…However, cross-sectional study conducted in Shiraz showed that prevalence of nonadherence was 30.4%. 19 This small difference between our study and that of study conducted in Shiraz may be due to the fact that studies were done in different sociocultural areas. More over the difference could be due to differences in design of the studies that is in our study we used pre-post intervention study but the other study is cross sectional.…”

Section: Discussioncontrasting

confidence: 65%

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Factors Influencing Effectiveness of Peer Education Against Nonadherence to Antiretroviral Therapy Among Adult People Living with HIV/AIDS: A Pre-Post Intervention Study in Arsi Zone, Ethiopia

Hussein¹,

Dibaba²,

Wondu³

2020

HIV

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Background: Nonadherence to antiretroviral therapy (ART) among people with HIV/AIDS can lead to drug resistance and death. Different studies have defined nonadherence, and it denotes at least one missed dose of ART within 28 days. One of the strategies to prevent nonadherence to ART could be peer education. However, published studies which test out whether or not peer education is effective for prevention of nonadherence to ART among adults living with HIV were not available. Moreover, published studies on factors discussing the success of peer education against nonadherence to ART were not available, so we conducted this study. Objectives: To determine effectiveness of peer education against nonadherence to ART and identify factors influencing the effectiveness of peer education for prevention of nonadherence to ART among people living with HIV/AIDS in Arsi zone, Ethiopia. Methods: An institution based pre-post intervention study was conducted. The intervention was giving peer education for three months. Frequencies and percentages were used to describe the data. Binary and multivariate logistic regressions were used to assess the variables. Results: The data was collected from 355 and 319 people with HIV/AIDS at pre-and postintervention stages, respectively. Experiencing an ART side effect, reminder to take ART, gender, marital status and monthly income were associated with nonadherence. More study participants who had not useda reminder to take ART service missed at least one dose of ART when compared to those who used a reminder to take ART service (adjusted odds ratio (AOR) =6.21; 95% CI=2.12-18.20). Conclusion: Experiencing a side effect of ART influenced effectiveness of peer education negatively while using reminder to take ART influenced effectiveness positively. Peer education is effective for reduction of nonadherence to ART if it is used with reminder to take ART. This study can be a base for further studies that should be conducted in various areas, since peer education can be influenced by sociodemographic and economic factors.

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Section: Discussioncontrasting

confidence: 65%

“…3 Study in Brazil found that nonadherence to ART among patients initiating the therapy was 36.9% in 2005. 4 A study conducted in Northwest Ethiopia indicated that nonadherence to ART among adult hospitalized patients was 19.1% in 2014. 5 Nonadherence to ART is related to different factors.…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Effectiveness of Peer Education Against Nonadherence to Antiretroviral Therapy Among Adult People Living with HIV/AIDS: A Pre-Post Intervention Study in Arsi Zone, Ethiopia

Hussein¹,

Dibaba²,

Wondu³

2020

HIV

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“…The study is higher than studies done in Northern Ethiopia (62.3%), 24 Southern Ethiopia (60%,56%), 25,26 Eastern Ethiopia (65%), 27 Western Africa (62.6%), 28 Southern-central Africa (63.81%), 29 Southern Africa (70.8%), 30 and Western Asia (69.6%). 31 This variation might be due to differences in adherence measurement, and socio-demographic characteristics. In this study, relationships were found between ART adherence and different variables.…”

Section: Discussionmentioning

confidence: 99%

Antiretroviral Treatment Adherence and Determinant Factors Among Adult People Infected with Human Immunodeficiency Virus in Eastern Tigray General Hospitals, Northern Ethiopia, 2019

Gebreagziabher¹,

Woldemariam²

2020

HIV

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Background: Human immune deficiency virus is a significant cause of morbidity and mortality, especially in developing countries. Globally, about 37.9 million people had HIV/ AIDS in 2018 and 36.2 million people were adults, Moreover, about 770,000 AIDS-related mortality occurred in adult infected people. Appropriate antiretroviral therapy adherence is important to minimize drug resistance, improve virological response, and decrease morbidity and mortality. Researches done in Ethiopia reported knowledge on antiretroviral therapy adherence and determinant factors were limited and the literature was scared. Moreover, the eastern zone of Tigray was inhabited with a highly rural population and this may be a significant facilitator and barrier to ART adherence. According to a census conducted by the central agency of Ethiopia in 2013, the eastern zone of Tigray has a population of 755,343, of whom 395,705 are women and 609,279 (80.66%) are rural inhabitants. Objective: This study aimed to assess antiretroviral therapy adherence and determinant factors among Adult HIV infected people in eastern Tigray, 2019. Methods: A cross-sectional study design was conducted from January 1 to June 30 2019 on 339 adults attending the antiretroviral clinic at eastern Tigray. A systematic random sampling method was used to pick the study samples. Data were collected by a structured questionnaire using face to face interview. P-value < 0.05 in multivariate analysis was used as a cutpoint for the statistical significance of the association. Results: About 74.6% of participants were adhering to antiretroviral therapy. Place of residence (AOR= 5.13 (1.63-13.44), social support (AOR=2.71 (1.37-9.74), HIV disclosure (AOR=3.32 (1.43-9.24), free from depression (AOR=2.54 (1.36-9.43) and free from substance use (AOR=3.42 (1.67-10.87) were the factors associated with adherence to antiretroviral therapy. Conclusion and Recommendation: Drug adherence in eastern Tigray was low and place of residence, social support, HIV disclosure, free from depression and free substance use were the factors associated with ART. So, awareness creation for rural residence, social support, avoidance of depression, and substance use should be strengthened to increase drug adherence.

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“…HIV of course is the big story here, with authors reporting adherence to ART23, physical activity24 and disputes over HIV diagnosis by ELISA25, hepatitis C26 and surveillance of epidemic prone diseases 27…”

Section: Infectionsmentioning

confidence: 99%

Sexuality and other issues in Africa and beyond

Tumwine¹

2018

Afr H. Sci.

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Non- adherence to anti-retroviral medication in Shiraz, 2014: a cross sectional study

Cited by 10 publications

References 23 publications

<p>Factors Influencing Effectiveness of Peer Education Against Nonadherence to Antiretroviral Therapy Among Adult People Living with HIV/AIDS: A Pre-Post Intervention Study in Arsi Zone, Ethiopia</p>

<p>Factors Influencing Effectiveness of Peer Education Against Nonadherence to Antiretroviral Therapy Among Adult People Living with HIV/AIDS: A Pre-Post Intervention Study in Arsi Zone, Ethiopia</p>

<p>Antiretroviral Treatment Adherence and Determinant Factors Among Adult People Infected with Human Immunodeficiency Virus in Eastern Tigray General Hospitals, Northern Ethiopia, 2019</p>

Sexuality and other issues in Africa and beyond

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