A New Furanoheliangolide Sesquiterpene Lactone fromCalea pinnatifida(R. Br.) Less. (Asteraceae) and Evaluation of Its Trypanocidal and Leishmanicidal Activities

The genus Calea L.: A review on traditional uses, phytochemistry, and biological activities

“…Sesquiterpenes lactones constitute the largest group of metabolites found in Calea species, and several biological activities have been assigned for this chemical class (Lima et al, ; Ohguchi et al, ; Umemura et al, ; Wu et al, ). One hundred forty‐three (1–143) compounds belonging to this chemical category have been isolated in Calea plants, including 63 heliangolides (1–63), 44 germacranolides (64–107), 24 guianolides (108–131), and 12 eudesmanolides (132–143).…”

“…In another study, Lima et al () evaluated leishmanicidal and trypanocidal effects of six compounds (2, 182, vanillin, phytol, 3,4‐di‐ O ‐ E ‐caffeoylquinic acid, and 4,5‐di‐ O ‐ E ‐caffeoylquinic acid), isolated from ethanol extract of C. pinnatifida , against L. amazonensis and T. cruzi intracellular amastigotes. Benznidazole 20 μM and amphotericin B 2 μM, used as positive controls, showed 82.67% of growth inhibition against T. cruzi and 86.88% against L. amazonensis , respectively.…”

“…Furanoheliangolide 2 revealed a strong leishmanicidal and trypanocidal activity, with IC 50 values of 8.30 and 5.27 μM, respectively. The other compounds exhibited weak or no percentage of inhibition against intracellular amastigotes of both T. cruzi and L. amazonensis (Lima et al, ).…”

“…Many reports in the literature tender for support of the traditional uses of Calea and show that this genus contains compounds that present several biological activities, including leishmanicidal (Lima et al, ; Lima et al, ), trypanocidal (Lima et al, ; Lima et al, ), antihypertensive (Guerrero et al, ), antinociceptive, antidiarrheal (Salaga et al, ), antifungal (Flach et al, ), antiplasmodial (Kohler et al, ), acaricidal (Ribeiro, Avancini, Goncalves, Toigo, & von Poser, ), antimicrobial (Do Nascimento, Salvador, Candido, Ito, & De Oliveira, ), anti‐inflammatory (Gómez & Gil, ), antidiabetic (Roman, Alarcon‐Aguilar, Lara‐Lemus, & lores‐Saenz, ), and cytotoxic activities (Nakagawa et al, ).…”

The genus Calea L.: A review of isolated compounds and biological activities

“…Those showing trypanocidal activity in vitro were ethyl caffeate (C146) and a mixture of butein (C218) + orobol (C219), displaying IC 50 values of 18.27 and 26.53 μM, respectively (Lima et al, 2017) (Figure 6). …”