Untargeted LC–MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

Chibli, Lucas Apolinário; Rosa, Annylory Lima; Nonato, Maria Cristina; Costa, Fernando B. Da

doi:10.1007/s11306-019-1520-7

Cited by 13 publications

(10 citation statements)

References 209 publications

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“…The metabolomics approach is used in large-scale studies of metabolites and, when applied to plants, it involves high-throughput analyses of complex metabolite mixtures. For example, plant metabolomic studies can focus on the investigation of abiotic effects on plants metabolism, to find bioactive compounds in plant matrices [ 25 ], in the biogeography of species [ 75 ], employed as an authentication tool or quality control for food products [ 35 , 87 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics as a marketing tool for geographical indication products: a literature review

Cassago

Artêncio

Giraldi

et al. 2021

Eur Food Res Technol

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Geographical indication (GI) is used to identify a product's origin when its characteristics or quality are a result of geographical origin, which includes agricultural products and foodstuff. Metabolomics is an “omics” technique that can support product authentication by providing a chemical fingerprint of a biological system, such as plant and plant-derived products. The main purpose of this article is to verify possible contributions of metabolomic studies to the marketing field, mainly for certified regions, through an integrative review of the literature and maps produced by VOSviewer software. The results indicate that studies based on metabolomics approaches can relate specific food attributes to the region’s terroir and know-how. The evidence of this connection, marketing of GIs and metabolomics methods, is viewed as potential tool for marketing purposes (e.g., to assist communication of positive aspects and quality), and legal protection. In addition, our results provide a taxonomic categorization that can guide future marketing research involving metabolomics. Moreover, the results are also useful to government agencies to improve GIs registration systems and promotion strategies. Supplementary Information The online version contains supplementary material available at 10.1007/s00217-021-03782-2.

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Section: Introductionmentioning

confidence: 99%

Metabolomics as a marketing tool for geographical indication products: a literature review

Cassago

Artêncio

Giraldi

et al. 2021

Eur Food Res Technol

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“…The structure of L. major DHODH was revealed by X-ray diffraction analysis [189]. It was reported that natural compounds from Asteraceae species could inhibit LmDHODH by Chibli et al, though the antileishmanial effect of the compounds has not been evaluated [190].…”

Section: Dihydroorotate Dehydrogenase (Dhodh Ec 1352)mentioning

confidence: 99%

Toward New Antileishmanial Compounds: Molecular Targets for Leishmaniasis Treatment

Istanbullu¹,

Bayraktar²

2022

Leishmaniasis - General Aspects of a Stigmatized Disease

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The leishmaniases are a group of diseases caused by protozoan parasites—Leishmania sp. Leishmaniasis is classified among the 20 neglected diseases by WHO. Although the disease has been known for more than 120 years, the number of drugs used for the treatment is still limited to 5–6. The first-line drugs against leishmaniasis are pentavalent antimonials, which were introduced to the treatment 70 years ago—despite all their side effects. Molecular targets are becoming increasingly important for efficacy and selectivity in postgenomic drug research studies. In this chapter, we have discussed potential therapeutic targets of antileishmanial drug discovery such as pteridine reductase (PTR1), trypanothione reductase (TR), N-myristoyltransferase (NMT), trypanothione synthetase (TryS), IU-nucleoside hydrolase, and topoisomerases, enzymes and their inhibitors reported in the literature.

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“…Mishra and Mohapatra noted that SistematX was an easy tool for metabolomic studies . Chibli et al profiled over 2000 metabolites from the Asteraceae family while screening for inhibitors of Leishmania major dihydroorotate dehydrogenase . In a database-driven approach to identify diterpene synthases in the Lamiaceae family, the authors criticized the inability to perform bulk downloads in the SistematX environment, which limited their ability to assess its completeness and cross-reference it with other data .…”

Section: Introductionmentioning

confidence: 99%

“…18 Chibli et al profiled over 2000 metabolites from the Asteraceae family while screening for inhibitors of Leishmania major dihydroorotate dehydrogenase. 19 In a database-driven approach to identify diterpene synthases in the Lamiaceae family, the authors criticized the inability to perform bulk downloads in the SistematX environment, which limited their ability to assess its completeness and cross-reference it with other data. 20 They suggested that the development of a tool to download publicly available digital data would be beneficial to the field.…”

Section: Introductionmentioning

confidence: 99%

The SistematX Web Portal of Natural Products: An Update

Costa

Lucena

Silva

et al. 2021

J. Chem. Inf. Model.

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Natural products and their secondary metabolites are promising starting points for the development of drug prototypes and new drugs, as many current treatments for numerous diseases are directly or indirectly related to such compounds. State-of-the-art, curated, integrated, and frequently updated databases of secondary metabolites are thus highly relevant to drug discovery. The SistematX Web Portal, introduced in 2018, is undergoing development to address this need and documents crucial information about plant secondary metabolites, including the exact location of the species from which the compounds were isolated. SistematX also allows registered users to log in to the data management area and gain access to administrative pages. This study reports recent updates and modifications to the SistematX Web Portal, including a batch download option, the generation and visualization of 1H and 13C nuclear magnetic resonance spectra, and the calculation of physicochemical (drug-like and lead-like) properties and biological activity profiles. The SistematX Web Portal is freely available at .

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Untargeted LC–MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

Cited by 13 publications

References 209 publications

Metabolomics as a marketing tool for geographical indication products: a literature review

Metabolomics as a marketing tool for geographical indication products: a literature review

Toward New Antileishmanial Compounds: Molecular Targets for Leishmaniasis Treatment

The SistematX Web Portal of Natural Products: An Update

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