Crystal Structures of 1-Aryl-1H- and 2-Aryl-2H-1,2,3-triazolyl Hydrazones. Conformational Consequences of Different Classical Hydrogen Bonds

Abstract

The crystal structures of (Z)-1-phenyl-4-[((2-phenylhydrazono)methyl)]-1H-1,2,3-triazole, (Z)-4- [(2-(2,4-

(E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests

“…In the NOESYmap, it showed correlation between NH/H Me and it was in agreement for a geometric (E)configuration in this sole isomer for this C=N bond. The steric hindrance of the phenylamino moiety on this C=N bond is certainly the major factor that induces this unique E-stereochemistry and was in agreement with results of the literature (Syakaev et al, 2006;Patorski et al, 2013;Ershov et al, 2009;Gonzaga et al, 2016;Glidewell et al, 2004). HRMS of 1c completed the analytical data and was in accordance with this structure.…”

New sulfonamides containing organometallic-acylhydrazones: synthesis, characterisation and biological evaluation as inhibitors of human carbonic anhydrases

“…Three cytosolic human (h) isoforms (hCA I, II, and VII) and one mitochondrial (hCA VA) have been included for the screening, and the results revealed interesting selectivity profiles for some of the evaluated compounds. Inhibition data obtained with the standard stopped-flow CO 2 hydrase assay are compared to those of the standard sulfonamide inhibitor acetazolamide ( AAZ ) 43–47 (Table 1). Structure-activity relationships have been delineated dividing the compounds into three classes, depending on the organic portion responsible for the CA inhibition.…”