(E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests

Abstract

E)-N'-[1-(3-Oxo-3H-benzo[f]chromen-2-yl)ethylidene benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests

A novel synthetised sulphonylhydrazone coumarin (E)‐4‐methyl‐N′‐(1‐(3‐oxo‐3H‐benzo[f]chromen‐2‐ yl)ethylidene)benzenesulphonohydrazide protect against isoproterenol‐induced myocardial infarction in rats by attenuating oxidative damage, biological changes and electrocardiogram

“…Scheme 1 describes the synthetic route of (E)‐4‐methyl‐N′‐(1‐(3‐oxo‐3H‐benzo[f]chromen‐2‐yl)ethylidene)benzenesulphonohydrazide (denoted as 5,6‐PhSHC). The synthesis of compound 1a was reported in our previous work 21–22 . Condensation of 1a (0.3 g, 1.25 mmol) with P‐toulenesulphonhydrazide (0.23 g, 1.25 mmol) in ethanol (15 ml) and catalytic amount of acetic acid afforded the sulphonylhydrazone coumarin 5,6‐PhSHC in 68% yield as a white solid, with a melting point >266°C.…”

“…The synthesis of compound 1a was reported in our previous work. [21][22] Condensation of 1a (0. As shown in (Figure 2), the signals of compound 3), 13…”

Synthesis and Characterization of Biopotent Transition Metal Complexes of Schiff Base 2-{(1)-1-[2-(1,3-Benzothiazol-2-yl)hydrazinylidene]ethyl}-6,10b-dihydro-3H-benzo[f]chromen-3-one and their Biological Evaluation

“…Antibacterial activity: The newly synthesized compounds were tested for antibacterial activity against Gram-positive bacteria (S. aureus, B. subtilis) and Gram-negative bacteria (S. typhi and E. coli) by well diffusion assay with some modifications [16]. The Petri plates were prepared by pouring 20 mL of sterilized nutrient agar media under aseptic condition and allowed to solidify.…”

3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives: Synthesis, Characterization, and Evaluation on Tumor Cell Lines

“…In our group and as part of our program aimed at developing new methods for the preparation of new building blocks or, for the synthesis of 2-iminocoumarins showing potential biological properties dedicated to protection of rat tissues from isoproterenol toxicity [15] or, for cancer [16] [17], we were motivated in this work respectively for: 1) to prepare a class of hybrid derivatives of 2-iminocoumarins bearing a tetrazole pharmacophore, 2) to evaluate their antiproliferative activities on tumor cell lines and iii) to study their UV/visible properties.…”