Improving Natural Biopolymeric Membranes Based on Chitosan and Collagen for Biomedical Applications Introducing Silver

Ungureanu, Camelia; Ioniță, Daniela; Berteanu, Elena; Tcacenco, Luminita; Zuav, Adina; Demetrescu, Ioana

doi:10.5935/0103-5053.20150298

Cited by 8 publications

(10 citation statements)

References 31 publications

(34 reference statements)

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“…The antimicrobial activity of the developed active edible films was investigated against Gram-negative ( E. coli , CECT 434) and Gram-positive ( S. aureus , CECT 239) bacteria. The optical density method was followed by using the Biomate-3 UV-Vis spectrophotometer at 540 nm [ 58 ]. In this method, the turbidity measurement can be used as an indicator of the bacterial growth since the transmission of light decreases as the cell population increases.…”

Section: Methodsmentioning

confidence: 99%

Impact of Olive Extract Addition on Corn Starch-Based Active Edible Films Properties for Food Packaging Applications

Valdés

Álvarez-Pérez

Rojas

et al. 2020

Foods

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Active edible films based on corn starch containing glycerol as a plasticizer and an olive extract obtained from Spanish olive fruit (Olea europaea) by-products (olive extract; OE) at different concentrations (0, 0.05, 0.1 and 0.2 wt%) were prepared by using the casting technique and further solvent-evaporation. OE showed high total phenolic and flavonoids contents and antioxidant activity, which was evaluated by using three different methods: free radical scavenging assay by (1, 1-Dipheny l-2-picrylhydrazyl) DPPH, 2, 2-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) ABTS radical inhibition and ferric reducing antioxidant power (FRAP). The incorporation of OE into the corn starch/glycerol matrix underlined the antioxidant potential and antimicrobial effect against E. coli and S. aureus of these novel active films, being noticeable for films added with 0.2 wt% OE. The developed active films showed a clear thermo-oxidative stability improvement with OE incorporation, in particular at 0.2 wt% loading with an increase of around 50 °C in the initial degradation temperature (Tini) and oxidation onset temperature (OOT). The functional properties of control films were also improved with OE addition resulting in a decrease in Young’s modulus, elongation at break, shore D hardness and water vapor permeability. The present work suggested the potential of the developed corn starch-based edible films as low-price and sustainable food packaging systems to prevent the oxidative deterioration of packaged foodstuff while reducing also the generation of olive by-products.

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Section: Methodsmentioning

confidence: 99%

Impact of Olive Extract Addition on Corn Starch-Based Active Edible Films Properties for Food Packaging Applications

Valdés

Álvarez-Pérez

Rojas

et al. 2020

Foods

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“…In addition, the adsorption bands at 2850 and 2950 cm −1 corresponded to CH stretching vibration bands of PCL. Furthermore, the stretching vibration band of NH group appeared at 3324 cm −1 attributing to amine in Col structure immobilized on PCL–BCP–Col–BMP‐2 …”

Section: Resultsmentioning

confidence: 99%

Bone morphogenetic protein‐2 immobilization on porous PCL‐BCP‐Col composite scaffolds for bone tissue engineering

Song

Amirian

Linh

et al. 2017

J of Applied Polymer Sci

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The objective of this study was to develop novel porous composite scaffolds for bone tissue engineering through surface modification of polycaprolactone-biphasic calcium phosphate-based composites (PCL-BCP). PCL-BCP composites were first fabricated with salt-leaching method followed by aminolysis. Layer by layer (LBL) technique was then used to immobilize collagen (Col) and bone morphogenetic protein (BMP-2) on PCL-BCP scaffolds to develop PCL-BCP-Col-BMP-2 composite scaffold. The morphology of the composite was examined by scanning electron microscopy (SEM). The efficiency of grafting of Col and BMP-2 on composite scaffold was measured by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). Both XPS and FTIR confirmed that Col and BMP-2 were successfully immobilized into PCL-BCP composites. MC3TC3-E1 preosteoblasts cells were cultivated on composites to determine the effect of Col and BMP-2 immobilization on cell viability and proliferation. PCL-BCP-Col-BMP-2 showed more cell attachment, cell viability, and proliferation bone factors compared to PCL-BCP-Col composites. In addition, in vivo bone formation study using rat models showed that PCL-BCP-Col-BMP-2 composites had better bone formation than PCL-BCP-Col scaffold in critical size defect with 4 weeks of duration. These results suggest that PCL-BCP-Col-BMP-2 composites can enhance bone regeneration in critical size defect in a rat model with 4 weeks of duration.

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“…Additionally, a shift to higher frequencies in the amide bands designating the cross-linking may be the result of the coordinate or H-bonding interactions of the amide nitrogen. 34 , 49 , 50 The distinguishing absorption bands of newly formed C=N and C–N bonds owing to cross-linking with DMDF are overlapped by those of amide I, amide II, and amide III. C–H bending vibrations of the methyne group (1000–650 cm –1 ) stemmed from the absorption bands at 894 and 961 cm –1 in the CP sample and 902 and 969 cm –1 in the CDI sample.…”

Section: Resultsmentioning

confidence: 99%

Radiopaque Hemocompatible Ruminant-Sourced Gut Material with Antimicrobial Physiognomies for Biomedical Applications in Diabetics

et al. 2017

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This study comprises the fabrication of a radiopaque gut material with its mechanical properties conforming to the US Pharmacopeia guidelines giving an antimicrobial advantage for suture application, especially in conditions such as diabetes mellitus, which has a high wound infection rate. Schiff base cross-linking iodination of the material is evinced by the spectroscopic studies, and antimicrobial properties owing to released iodine are evinced through in vitro studies. Modified gut sutures demonstrated favorable physicomechanical features such as appropriate tensile strength (440 ± 20 MPa) and knot strength (270 ± 20) alongside a mean radiopacity value of 139.0 ± 10 in comparison with that of the femoral shaft with 160 ± 10. The diabetic model showed absence of clinical signs of infection, supported by wound swab culture and the absence of necrosis in histology. Hemocompatibility studies evinced the absence of contact platelet activation and hemolysis alongside the customary coagulation response. These promising results highlight the stimulating potential of the process in the development of biomedical applications, necessitating persistent studies for its evidence-based applicability, particularly in diabetic patients.

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Improving Natural Biopolymeric Membranes Based on Chitosan and Collagen for Biomedical Applications Introducing Silver

Cited by 8 publications

References 31 publications

Impact of Olive Extract Addition on Corn Starch-Based Active Edible Films Properties for Food Packaging Applications

Impact of Olive Extract Addition on Corn Starch-Based Active Edible Films Properties for Food Packaging Applications

Bone morphogenetic protein‐2 immobilization on porous PCL‐BCP‐Col composite scaffolds for bone tissue engineering

Radiopaque Hemocompatible Ruminant-Sourced Gut Material with Antimicrobial Physiognomies for Biomedical Applications in Diabetics

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