Determination of Aspirin Using Chemiluminescence System of Tris(1,10 phenanthroline)Ruthenium(II)-Cerium(IV)

Mokhtari, Ali; Keyvanfard, Mohsen; Emami, Iraj; Delouei, Nastaran Jafari; Pishkhani, Hatameh F.; Ebrahimi, Aida; Karimian, Hossein

doi:10.5935/0103-5053.20150288

Cited by 5 publications

(6 citation statements)

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“…In this way, the analytical signal could be free from blank interferences from substances such as ascorbic acid and cysteine in human plasma. We used this strategy successfully for the determination of carminic acid, ketotifen, aspirin and, recently, hydroxyzine and mepivacaine in real samples. As can be seen in Figure S4 in Supporting Information, the CL kinetic profile of plasma did not have a detectable response at 10 sec after injection of Ce(IV) solution.…”

Section: Resultsmentioning

confidence: 99%

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Determination of pholcodine in syrups and human plasma using the chemiluminescence system of tris(1,10 phenanthroline)ruthenium(II) and acidic Ce(IV)

2016

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Pholcodine is an opiate derivative drug which is widely used in pediatric medicine. In this study, a chemiluminescence (CL) method is described that determines pholcodine in human plasma and syrup samples. This method is based on the fact that pholcodine can greatly enhance the weak CL emission of reaction between tris(1,10 phenanthroline)ruthenium(II), Ru(phen) , and acidic Ce(IV). The CL mechanism is described in detail using UV-vis light, fluorescence and CL spectra. Effects of chemical variables were investigated and under optimum conditions, CL intensity was proportional to the pholcodine concentration over the range 4.0 × 10 to 8.0 × 10 mol L . The limit of detection (LOD) (S/N = 3) was 2.5 × 10 mol L . Percent of relative standard deviations (%RSD) for 3.0 × 10 and 3.0 × 10 mol L of pholcodine was 2.9 and 4.0%, respectively. Effects of common ingredients were investigated and the method was applied successfully to the determination of pholcodine in syrup samples and human plasma.

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Section: Resultsmentioning

confidence: 99%

“…Therefore, a CL system may be suitable for coupling with a separation method but another CL system may not be suitable. For example luminol and lucigenin reactions occur often in alkaline medium, but Ru(II) complexes like Ru(phen) 3 2+ are often oxidized in acidic media …”

Section: Introductionmentioning

confidence: 99%

Determination of pholcodine in syrups and human plasma using the chemiluminescence system of tris(1,10 phenanthroline)ruthenium(II) and acidic Ce(IV)

2016

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“…The current method developed is advantageous over other reported methods except [44] in terms of sensitivity with a linear range of 5.6×10 -9 M (2.25 ng×ml -1 )-2.2×10 -6 M (882.2 ng×ml -1 ) and LOD of 1.5×10 -9 M (0.602 ng×ml -1 ). In addition to MF other drugs have also been analysed using CL system, aspirin was determined using a system of tris(1,10 phenanthroline)ruthenium(ii)-Ce (IV), which was linear over the range of 0.72-72.00 µg×ml -1 and LOD of 0.45 µg×ml -1 [45] . Some FQ were determined using the same sensitizer system [46] with linear range between 0.003-0.7 mg×ml −1…”

Section: +mentioning

confidence: 99%

Flow Injection Determination of Moxifloxacin using Silver Nanoparticles with Tris(2,2-Bipyridyl)Ruthenium(III)-Ce(IV) Chemiluminescence Detection

Wabaidur¹,

Alam²,

ALOthman³

et al. 2017

pharmaceutical-sciences

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Wabaidur and Alam: Moxifloxacin Analysis using Ru(bipy) 3 2+-Ce(IV) Chemiluminescence System Silver nanoparticles were synthesized and applied to sensitize Ru(bipy) 3 2+-Ce(IV) chemiluminescence system for the quantitative estimation of moxifloxacin. Prior to the experiment, silver nanoparticles were prepared using the well-reputed aqueous-gaseous phase reaction between ammonia and solution of silver nitrate. The utilization of silver nanoparticle was found to have enhanced effect on the weak chemiluminescence intensity of Ru(bipy) 3 2+-Ce(IV) system. Additionally, the enrichment of the intensity was linearly proportional to the concentration of target compound. The effects of different experimental parameters were checked to obtain best results. Under the ideal experimental conditions, the linearity of the proposed method was obtained over the moxifloxacin concentration range of 5.6×10 -9 -2.2×10 -6 M with the correlation coefficient (r 2 ) value 0.9998. The detection limit was found to be 1.5×10-9 M and the relative standard deviation calculated from five replicate measurements was 2.1%. The interference from various foreign species for the analysis of moxifloxacin was tested since they may suppress or enhance the chemiluminescence signal. The obtained quality parameters and no significant interference effect on the intensity confirm that the method is reproducible, simple and could be applied for the successful evaluation of moxifloxacin in commercial tablet and human urine.

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“…The CL spectrum (shown in Figure 9) is similar to emission spectrum of SO2* molecule. Based on above discussions, following mechanism is proposing for this CL reaction [40,41]. Zolpidem undergoes oxidation by N-demethylation, N-oxidation, decarboxylation, and oxidation of methyl groups and hydroxylation of a position on the imidazolepyridine ring [42].…”

Section: Possible Mechanismmentioning

confidence: 99%

Chemiluminescence System of Permanganate-Sulfite for Simple Determination of Zolpidem

Mokhtari¹,

Aaghamohammadhasan²

2016

Eurasian J Anal Chem

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Zolpidem is an imidazopyridine agent for short term treatment of insomnia with a favorable adverse effect profile. A novel chemiluminescence (CL) method has been proposed for simple determination of zolpidem. The method is based on the fact that zolpidem can produce CL emission in the system of acidic KMnO4 (permanganate) and Na2SO3 (sulfite). On the optimized conditions of chemical variables, CL intensity was proportional to concentration of zolpidem in the range 2.5-295.1 ng mL-1. Limit of detection was 1.6 ng mL-1 (S/N=3). The percent of relative standard deviation was 4.5% for 98.4 ng mL-1 zolpidem. The proposed method was satisfactorily applied for the determination of zolpidem in pharmaceutical formulations and human plasma samples. Sampling rate of the method was calculated about 30 samples h-1. CL mechanism has been proposed using UV-Vis and CL spectra.

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Determination of Aspirin Using Chemiluminescence System of Tris(1,10 phenanthroline)Ruthenium(II)-Cerium(IV)

Cited by 5 publications

References 0 publications

Determination of pholcodine in syrups and human plasma using the chemiluminescence system of tris(1,10 phenanthroline)ruthenium(II) and acidic Ce(IV)

Determination of pholcodine in syrups and human plasma using the chemiluminescence system of tris(1,10 phenanthroline)ruthenium(II) and acidic Ce(IV)

Flow Injection Determination of Moxifloxacin using Silver Nanoparticles with Tris(2,2-Bipyridyl)Ruthenium(III)-Ce(IV) Chemiluminescence Detection

Chemiluminescence System of Permanganate-Sulfite for Simple Determination of Zolpidem

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