Discrimination ofAnnona muricataandRollinia mucosaExtracts by Using Multivariate Curve Resolution and Partial Least-Squares Regression of Liquid Chromatography-Diode Array Data

Afonso, Sabrina; Pisano, Pablo L.; Silva, Fabiano; Scaminio, Ieda; Olivieri, Alejandro C.

doi:10.5935/0103-5053.20150210

Cited by 4 publications

(6 citation statements)

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“…The fruits, leaves, stems and roots of Graviola are known to be rich in flavonoids, isoquinoline alkaloids and annonaceous acetogenins [2,[33][34][35][36][37][38][39][40]. It is reported [41,42] that absorption peaks from 200 to 230 nm are characteristic of acetogenins. In case of PB-WE and S-WE extracts we find that specifically a broad band peak in this wavelength dominating.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Harnessing of the Graviola Bioactive Components Using a Neoteric Sonication Cum Microwave Coadjuvant Extraction Protocol

et al. 2018

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Graviola is one of the most accomplished natural anticancer therapists gaining popularity in recent times. Harnessing the full benefit from tapping all of its rich bioactive reservoirs is absolutely worthy and mandatory. It is in this regard that a well optimized extraction methodology gains paramount importance. In case of Graviola, no sophistication in terms of extraction methods is reported. A neoteric sonication cum microwave combined extraction technology was introduced that maximized the extraction process and minimized (7 min) the extraction time. The extraction efficiency was validated based on the significant enrichment of bioactive ingredients in Graviola extracts following the sonication cum microwave combined protocol.

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Section: Resultsmentioning

confidence: 99%

Enhanced Harnessing of the Graviola Bioactive Components Using a Neoteric Sonication Cum Microwave Coadjuvant Extraction Protocol

et al. 2018

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“…In addition to the interspecific factor, these discrepant results may occur, among other issues, due to technical, ecological or physiological factors, even within the species under study (Afonso et al, 2015;Fernandez et al, 2018;Nendissa et al, 2021;Shehata et al, 2021;Villalva et al, 2021). Phytochemical diversity is related to several plant ecophysiological functions and seasonal variation of secondary metabolites in response to phenology and climate must be considered (Yeshi et al, 2022), as observed for tannins in Xylopia emarginata (Medeiros et al, 2021).…”

Section: Preliminary Phytochemical Prospec Ng Of Hydroalcoholic Extractsmentioning

confidence: 99%

Phytochemical screening and potential antioxidant, antibacterial and anti-melanoma activities of Rollinia dolabripetala leaves

Campos¹,

Oliveira²,

Silva-Júnior³

et al. 2022

NRFHH

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Plants are an important source of natural compounds used for medicine. The Annonaceae family exhibits a cytotoxic effect on different tumor strains and on several bacterial strains. This unprecedented study investigates the antioxidant, anti-melanoma, anti-staphylococcal and anti-streptococcal potential of hydroalcoholic extracts of Rollinia dolabripetala leaves and of 1.7 -dihydroxyxanthone and xanthone phytocompounds. The determination of the antioxidant capacity was performed by the DPPH and lipid peroxidation methods. Isolated phytochemicals xanthone and 1.7-dihydroxyxanthone were also included in cytotoxicity and antimicrobial tests. Assays for antitumor leaf potential were performed on melanoma carcinogenic cells and assays for antibacterial potential were performed on Gram-positive Staphylococcus aureus 29213 (SA13), S. aureus 4075 (SA75) and Streptococcus bovis-01 (SB01) strains. The phytochemical prospection revealed the presence of flavonols, tannins and xanthones. Halo inhibition (mm) of Gram-positive SA13 was 7.00 ± 0.38. There was no inhibitory effect on SA75 and SB01 strains. The antitumor activity, expressed in the minimum lethal concentration (GI50) was in μg/mL: R. dolabripetala: 47.04, 1.7-dihydroxyxanthone: 0.98, Xanthone: 3.38, and 5-Fluorouracil: 0.24. When comparing treatments with 5-Fluorouracil, the best correlation between dosage and the inhibition rate occurs with 1.7-dihydroxy-xanthone followed by R. dolabripetala treatment. In conclusion, R. dolabripetala exhibits antioxidant, anti-staphylococcal and anti-melanoma bioactivities with 1.7-dihydroxy-xanthone exhibiting the best correlation between dosage and inhibition rate. Phytochemicals such as, flavonols, tannins and xanthone reinforce the biological results obtained. The seasonal factor in the collection of plant samples may explain the discrepancies in the phytochemical data of R. dolabripetala compared to other species of the genus.

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“…The remainder was evaporated in a rotary evaporator, removing all the solvent still present in the sample, until attaining constant weight. 31,37 HPLC analysis 3.0 mg of the crude extract were dissolved in 1.0 mL of methanol. Twenty microliters of this extract were added to 10 mL of the mobile phase (35% methanol, 35% acetonitrile, 30% water).…”

Section: Extract Preparationmentioning

confidence: 99%

“…Our research group has used statistical mixture designs for the development of fingerprint profiles for extracted metabolites of plant material. [29][30][31][32][33][34] This procedure is important because the extraction conditions differ greatly for different types of metabolomic compounds. The choice of solvents involves compromise between maximizing the efficiency of the interactions between molecules while insuring the extraction of an expressive number of metabolites depending on the case under study.…”

Section: Introductionmentioning

confidence: 99%

Influence of Seasonality and Sunlight Effects on Rollinia mucosa Leaves Fingerprint

Afonso¹,

Silva²,

Marcheafave³

et al. 2018

J. Braz. Chem. Soc.

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Rollinia mucosa fruit has generated great interest due to the presence of bioactive compounds, which exhibit promising biological activities. Fingerprinting analytical techniques, chromatographic-diode array detection (DAD), infrared, mass spectrometric, 1 H and 13 C nuclear magnetic resonance (NMR) spectra, associated with chemometric analysis and mixture design, were used to determine chemical discriminations of sun-exposed and self-shaded leaves of Rollinia mucosa in each of the four seasons. Sunlit leaves in winter presented higher metabolite signals related to the acetogenins, whereas shaded leaves have higher abundances of carbohydrates and terpenes. Sunlit leaves harvested in the summer had the smallest metabolite abundances. Fingerprints confirmed the presence of two acetogenins, annonacin A and annonastatin. Ternary and quaternary mixtures of the statistical mixture design were most effective for revealing important discriminations.

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Discrimination ofAnnona muricataandRollinia mucosaExtracts by Using Multivariate Curve Resolution and Partial Least-Squares Regression of Liquid Chromatography-Diode Array Data

Cited by 4 publications

References 1 publication

Enhanced Harnessing of the Graviola Bioactive Components Using a Neoteric Sonication Cum Microwave Coadjuvant Extraction Protocol

Enhanced Harnessing of the Graviola Bioactive Components Using a Neoteric Sonication Cum Microwave Coadjuvant Extraction Protocol

Phytochemical screening and potential antioxidant, antibacterial and anti-melanoma activities of <i>Rollinia dolabripetala</i> leaves

Influence of Seasonality and Sunlight Effects on Rollinia mucosa Leaves Fingerprint

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