Square-Wave Voltammetric Determination of Paracetamol and Codeine in Pharmaceutical and Human Body Fluid Samples Using a Cathodically Pretreated Boron-Doped Diamond Electrode

Santos, Anderson M.; Vicentini, Fernando Campanhã; Deroco, Patrícia Batista; Rocha‐Filho, Romeu C.; Fatibello‐Filho, Orlando

doi:10.5935/0103-5053.20150203

Cited by 15 publications

(9 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is worth noting that the larger response and the lower oxidation potential of APAP indicates its higher electron transfer rate on H-BDDE (41). This observation is aligned with previously reported characterizations of APAP oxidation (42,43) and may be attributed to the enhancement in the interaction of APAP and reduced-carbon surface (44).…”

Section: Resultssupporting

confidence: 92%

Noninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics

Lin

Wang

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., sweat), play a critical role, because they can be deployed at a large scale to monitor the individuals’ drug transcourse profiles (semi)continuously and longitudinally. To this end, voltammetry-based sensing modalities are suitable, as in principle they can detect and quantify electroactive drugs on the basis of the target’s redox signature. However, the target’s redox signature in complex biofluid matrices can be confounded by the immediate biofouling effects and distorted/buried by the interfering voltammetric responses of endogenous electroactive species. Here, we devise a wearable voltammetric sensor development strategy—centering on engineering the molecule–surface interactions—to simultaneously mitigate biofouling and create an “undistorted potential window” within which the target drug’s voltammetric response is dominant and interference is eliminated. To inform its clinical utility, our strategy was adopted to track the temporal profile of circulating acetaminophen (a widely used analgesic and antipyretic) in saliva and sweat, using a surface-modified boron-doped diamond sensing interface (cross-validated with laboratory-based assays, R2 ∼ 0.94). Through integration of the engineered sensing interface within a custom-developed smartwatch, and augmentation with a dedicated analytical framework (for redox peak extraction), we realized a wearable solution to seamlessly render drug readouts with minute-level temporal resolution. Leveraging this solution, we demonstrated the pharmacokinetic correlation and significance of sweat readings.

show abstract

Section: Resultssupporting

confidence: 92%

Noninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics

Lin

Wang

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Between these analytical methods, the electroanalytical technique demonstrated major advantages in the study of biological fluid samples compared to other conventional methods such as chromatography and spectrophotometry [18]. Its advantages include greater flexibility, real-time analysis, low cost, and fast analysis time [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Computational determination the reactivity of salbutamol and propranolol drugs

Omer

Koparır²,

Ahmed

et al. 2020

Turkish Computational and Theoretical Chemistry

View full text Add to dashboard Cite

Gaussian software programs 09 was utilized to find the reactivity of salbutamol (SAL) and propranolol (PRO). Density Functional Theory (DFT) and Hartree-Fock (HF) were used to determine the energy band gaps. B3LYP/6-31++G(d,p) lower energy level was chosen as the base set. Geometrical structures with frontier molecular orbitals estimation for both the SAL and PRO. Atomic charge distribution and molecular electrostatic potential evaluation were performed for both drugs. For thermodynamic analysis Ab-initio DFT with HF at 6-31++G base sets were accomplished. The results showed that the PRO is more reactive than SAL.

show abstract

“…The limits of detection (LOD) and quantication (LOQ) were calculated using LOD ¼ 3 Â s/m and LOQ ¼ 10 Â s/m, with s being the standard deviation of ten blank measurements and m the calibration curve slope. 40…”

Section: Analytical Parametersmentioning

confidence: 99%

Simple, fast and environmentally friendly method to determine ciprofloxacin in wastewater samples based on an impedimetric immunosensor

et al. 2020

View full text Add to dashboard Cite

In this study an impedimetric immunosensor was developed in order to determine ciprofloxacin (CIP) in wastewater samples, an emergent contaminant widely found in wastewater. To achieve this, an anticiprofloxacin antibody was immobilized on the surface of a printed carbon electrode. Then, the developed immunosensor was applied in wastewater samples from Université Laval residences (Québec, Canada) through the load transfer resistance (R ct ) using [Fe(CN) 6 ] 3À/4À as a redox probe, and the average CIP concentration was found to be 2.90 Â 10 À4 mg mL À1 . The observed R ct changes presented a linear relationship from CIP concentrations of 10 À5 to 1.0 mg mL À1 , with detection and quantification limits of 2.50 Â 10 À6 and 7.90 Â 10 À6 mg mL À1 , respectively. The immunosensor presented high selectivity and repeatability, as well as a good recovery rate in wastewater samples (97%). Significant interference with other compounds was not observed. The proposed method requires only 30 mL of sample without the use of organic solvents or preceding sample preparation and/or extraction techniques. Moreover, the method is fast: only 20 min of incubation followed by 2 min of analysis time was sufficient to obtain the CIP concentration. The method's estimated cost is U$ 2.00 per sample.

show abstract

Square-Wave Voltammetric Determination of Paracetamol and Codeine in Pharmaceutical and Human Body Fluid Samples Using a Cathodically Pretreated Boron-Doped Diamond Electrode

Cited by 15 publications

References 2 publications

Noninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics

Noninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics

Computational determination the reactivity of salbutamol and propranolol drugs

Simple, fast and environmentally friendly method to determine ciprofloxacin in wastewater samples based on an impedimetric immunosensor

Contact Info

Product

Resources

About