Virginicin, a New Naphthalene from<i>Kosteletzkya virginica</i>(Malvaceae)

Bai, Bai; Gu, Xueting; Chen, Yu; Guan, Fuqin; Yu, Shuhui; Feng, Xianying

doi:10.5935/0103-5053.20150032

Cited by 3 publications

(4 citation statements)

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“…The other five isolates obtained were identified as the known compounds durantin C ( 6 ) [ 22 ], cleomiscosin A methyl ether ( 8 ) [ 17 ], jatrocin B ( 9 ) [ 29 , 30 ], venkatasin ( 10 ) [ 20 ], and 4′-O-methyl-cleomiscosin D ( 11 ) [ 31 ], by comparison of their physical and spectroscopic data with those reported in the literature. To date, only one coumarinolignan has been reported from the Malvaceae family [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of Waltheria indica

et al. 2022

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Seven new coumarinolignans, walthindicins A–F (1a, 1b, 2–5, 7), along with five known analogs (6, 8–11), were isolated from the roots of Waltheria indica. The structures of the new compounds are determined by detailed nuclear magnetic resonance (NMR), circular dichroism (CD) with extensive computational support, and mass spectroscopic data interpretation. Compounds were tested for their antioxidant activity in Human Cervical Cancer cells (HeLa cells). Compounds 1a and 6 showed higher reactive oxygen species (ROS) inhibitory activity at 20 μg/mL when compared with other natural compound-based antioxidants such as ascorbic acid. Considering the role of ROS in nuclear-factor kappa B (NF-κB) activation, compounds 1a and 6 were evaluated for NF-κB inhibitory activity and showed a concentration-dependent inhibition in Human Embryonic Kidney 293 cells (Luc-HEK-293).

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Section: Resultsmentioning

confidence: 99%

Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of Waltheria indica

et al. 2022

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“…Cytotoxicity assays: Cytotoxic activity was determined against human tumor cell lines Lovo, MDA-MB-231, HeLa cells with MTT method in 96-well microplates [15]. Lovo cells was maintained in Roswell Park Memorial Institute medium (1640) supplemented with 10% fetal bovine serum, 100 units/mL penicillin and 100 μg/mL streptomycin in 5% CO 2 at 37°C.…”

Section: Extraction and Isolationmentioning

confidence: 99%

“…The in vitro cytotoxic activity of compounds 1-6 was evaluated against three human tumor cell lines, Lovo, MDA-MB-231 and HeLa, by MTT method[15]. Taxol was used as a positive control.…”

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confidence: 99%

A New Quinolone Alkaloid with Cytotoxic Activity from the Fruits of Euodia Rutaecarpa

Liu

et al. 2018

Natural Product Communications

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A new quinolone alkaloid, 1-methyl-2-[( Z)-1-undecenyl]–4( 1H)-quinolone (1), together with two known quinolone alkaloids (2–3), and three known limonoids (4–6), were isolated from the fruits of Euodia rutaecarpa (Juss.) Benth.. Their chemical structure was determined by UV, MS, NMR and comparison with literatures. Bioassay results indicated that compound 1 had moderate cytotoxicity against tumor cell lines Lovo, MDA-MB-231 and HeLa with IC50 values of 6.72, 14.20 and 13.05 μM, respectively.

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“…Kosteletzkya pentacarpos L. (seashore mallow), formerly known as Kosteletzkya virginica (Liu et al, 2020(Liu et al, , 2021, is a perennial halophyte belonging to the Malva genus of the Malvaceae family. It is naturally distributed on the salt marshy coasts of eastern United States, and is commercially used for the production of oil (Ruan et al, 2008), feed (Sun et al, 2019), medicines (Bai et al, 2015), and beauty products (Qin et al, 2015). The plant was introduced in China in 1993 as a candidate species for the development of coastal tidal flats (Xu et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Integrated Analyses of Transcriptome and Chlorophyll Fluorescence Characteristics Reveal the Mechanism Underlying Saline–Alkali Stress Tolerance in Kosteletzkya pentacarpos

Zhou

Wang

et al. 2022

Front. Plant Sci.

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In recent years, soil salinization has become increasingly severe, and the ecological functions of saline–alkali soils have deteriorated because of the lack of plants. Therefore, understanding the tolerance mechanisms of saline–alkali-tolerant plants has become crucial to restore the ecological functions of saline–alkali soils. In this study, we evaluated the molecular mechanism underlying the tolerance of Kosteletzkya pentacarpos L. (seashore mallow) seedlings treated with 0.05 or 0.5% saline–alkali solution (NaCl: NaHCO3 = 4:1 mass ratio) for 1 and 7 days. We identified the key genes involved in tolerance to saline–alkali stress using orthogonal partial least squares regression analysis (OPLS-RA) based on both chlorophyll fluorescence indexes and stress-responsive genes using transcriptome analysis, and, finally, validated their expression using qRT-PCR. We observed minor changes in the maximum photochemical efficiency of the stressed seedlings, whose photosynthetic performance remained stable. Moreover, compared to the control, other indicators varied more evidently on day 7 of 0.5% saline–alkali treatment, but no variations were observed in other treatments. Transcriptome analysis revealed a total of 54,601 full-length sequences, with predominantly downregulated differentially expressed gene (DEG) expression. In the high concentration treatment, the expression of 89.11 and 88.38% of DEGs was downregulated on days 1 and 7, respectively. Furthermore, nine key genes, including KpAGO4, KpLARP1C, and KpPUB33, were involved in negative regulatory pathways, such as siRNA-mediated DNA methylation, inhibition of 5′-terminal oligopyrimidine mRNA translation, ubiquitin/proteasome degradation, and other pathways, including programmed cell death. Finally, quantitative analysis suggested that the expression of key genes was essentially downregulated. Thus, these genes can be used in plant molecular breeding in the future to generate efficient saline–alkali–tolerant plant germplasm resources to improve the ecological functions of saline–alkali landscapes.

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Virginicin, a New Naphthalene fromKosteletzkya virginica(Malvaceae)

Cited by 3 publications

References 0 publications

Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of Waltheria indica

Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of Waltheria indica

A New Quinolone Alkaloid with Cytotoxic Activity from the Fruits of Euodia Rutaecarpa

Integrated Analyses of Transcriptome and Chlorophyll Fluorescence Characteristics Reveal the Mechanism Underlying Saline–Alkali Stress Tolerance in Kosteletzkya pentacarpos

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