Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of Waltheria indica

Abstract

Seven new coumarinolignans, walthindicins A–F (1a, 1b, 2–5, 7), along with five known analogs (6, 8–11), were isolated from the roots of Waltheria indica. The structures of the new compounds are determined by detailed nuclear magnetic resonance (NMR), circular dichroism (CD) with extensive computational support, and mass spectroscopic data interpretation. Compounds were tested for their antioxidant activity in Human Cervical Cancer cells (HeLa cells). Compounds 1a and 6 showed higher reactive oxygen species (ROS) inhibitory activity at 20 μg/mL when compared with other natural compound-based antioxidants such as ascorbic acid. Considering the role of ROS in nuclear-factor kappa B (NF-κB) activation, compounds 1a and 6 were evaluated for NF-κB inhibitory activity and showed a concentration-dependent inhibition in Human Embryonic Kidney 293 cells (Luc-HEK-293).

The Potential of Cochlospermum tinctorium, Flueggea virosa, and Waltheria indica Traditional Plants From Burkina Faso in Treating Periodontitis: A Systematic Review

“…Due to the expected heterogeneity of the data and the paucity of experimental studies in humans, only a qualitative synthesis of the data could be provided. From the initial pool of 700 articles, a total of 11 studies were ultimately incorporated (Figure 2) [13,[18][19][20][21][22][23][24][25][26][27]; the majority of these (80%) of these were in vitro studies. Among the trio of plants, W. indica emerged as the most extensively scrutinized, accounting for 65% of the studies.…”

“…Additionally, two other studies evaluated the antioxidant properties of F. virosa [24] and W. indica [18]. In contrast, very little information is available regarding the pharmacological properties of C. tinctorium.…”

New Compounds from Terrestrial Plants: A Perspective View

“…New coumarolignans were obtained from the roots of Waltheria indica L. (Malvaceae) and were named walthindicins A-F [131]. Among the new compounds, walthindicin A (90) (Figure 19) exhibited the greatest inhibition of reactive oxygen species (ROS) and showed dose-dependent inhibition of the NF-κβ transcription factor in human embryonic kidney 293 cells (Luc-HEK-293).…”

New Compounds from Plants: A Perspective View

“…New coumarolignans were obtained from the roots of Waltheria indica L. (Malvaceae) and were named walthindicins A-F [131]. According to the author, among the new compounds, walthindicin A (96) exhibited the greatest inhibition of reactive oxygen species (ROS) and showed dose-dependent inhibition of the NF-κβ factor in human embryonic kidney 293 cells (Luc-HEK-293).…”