Chemical Composition and Cytotoxic Activity of the Root Essential Oil from<i>Jatropha ribifolia</i>(Pohl) Baill (Euphorbiaceae)

Silva, Celia E. L. da; Minguzzi, Sandro; Silva, Rogério C. L. da; Matos, Maria Auxiliadora Costa; Tófoli, Danilo; Carvalho, João Ernesto de; Ruiz, Ana Lúcia T. G.; Costa, Willian Ferreira da; Simionatto, Euclésio

doi:10.5935/0103-5053.20140253

Cited by 12 publications

(12 citation statements)

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“…It is relevant to mention the efficacy of the essential oils that have promising biological activities when the mixture of all their constituents, minor and major ones, is evaluated (Raut and Karuppayil 2014). It has been suggested, therefore, that minor constituents, due to the synergistic effect, are also crucial for the biological activities of essential oils (Silva et al 2015a). …”

Section: Resultsmentioning

confidence: 99%

In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)

Estevam

Deus

Silva

et al. 2017

An. Acad. Bras. Ciênc.

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Leishmaniasis and trypanosomiasis are globally widespread parasitic diseases which have been responsible for high mortality rates. Since drugs available for their treatment are highly hepatotoxic, nephrotoxic and cardiotoxic, adherence to therapy has been affected. Thus, the search for new, more effective and safer drugs for the treatment of these diseases is necessary. Natural products have stood out as an alternative to searching for new bioactive molecules with therapeutic potential. In this study, the chemical composition and antiparasitic activity of the essential oil from Protium ovatum leaves against trypomastigote forms of Trypanosoma cruzi and the promastigote forms of Leishmania amazonensis were evaluated. The essential oil was promising against trypomastigote forms of T. cruzi (IC 50 = 28.55 μg.mL -1 ) and L.amazonensis promastigotes (IC 50 = 2.28 μg.mL -1 ). Eighteen chemical constituents were identified by GasChromatography coupled to Mass Spectrometry (GC-MS) in the essential oil, whose major constituents were spathulenol (17.6 %), caryophyllene oxide (16.4 %), β-caryophyllene (14.0 %) and myrcene (8.4 %).In addition, the essential oil from P. ovatum leaves had moderate cytotoxicity against LLCMK 2 adherent epithelial cell at the concentration range under analysis (CC 50 = 150.9 μg.mL -1 ). It should be highlighted that this is the first report of the chemical composition and anti-Trypanosoma cruzi and anti-Leishmania amazonensis activities of the essential oil from Protium ovatum leaves.

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Section: Resultsmentioning

confidence: 99%

In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)

Estevam

Deus

Silva

et al. 2017

An. Acad. Bras. Ciênc.

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“…It has an anticancer property and cytotoxic property. This compound has been reported as cytotoxic compounds by inhibiting various types of neoplastic cell lines and some of the compounds are potent anticancer agents [35][36] .…”

Section: -Trifluoroacetoxytridecanementioning

confidence: 99%

Phytochemicals and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Taraxacum officinale (L).

Sasikala¹,

Ganesan²,

Jayaseelan³

et al. 2019

J. Drug Delivery Ther.

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Objective:To identify the phytochemical constituents present in ethanolic leaves extract of Taraxacum officinale (T. o) and to elucidate the bioactive compounds. Methods: The fresh leaves of T. officinale (1000g) were shade dried at room temperature for 30 days and the dried leaves were made into a fine powder. The ethanolic leaves extract obtained was dried with help of desiccator and rotatory evaporator. The dried samples tested for phytochemical analysis and bioactive compounds profiling through GC-MS analysis. Results: The phytochemical screening studies showed presence of alkaloids, flavonoids, phenol, cardiac glycosides and anthraquinones. in the leaves extract of T. officinale. GC-MS analysis showed 10 essential bioactive compounds and it revealed the presence of significant anticancer, Antimicrobial and antidiabetic compounds. Conclusions: The ethanol extract of T. o possess the most important phytochemical compounds and it has various medicinal properties to cure dangerous diseases and disorders.

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“…A review of recent literature confirmed that γ-eudesmol is identified here for the first time in the genus Jatropha . The essential oils of many Jatropha species have been studied including J. ribifolia , J. gossypifolia, and J. mutabilis (Da Silva et al, 2015, Aboaba et al, 2015, Okoh et al, 2016, Costa et al, 2014). The major constituents in J. ribifolia aerial part essential oil were identified as β-pinene, isoeugenol methyl ether, α-gurjunene, endo -8-hydroxy-cycloisolongifolene, α-pinene, and p -menth-1-en-8-ol, while phytol, spathulenol, epi -α-cadinol, caryophyllene oxide, germacerene D, and α-cadinol were the main components derived from J. mutabilis leaves essential oil.…”

Section: Resultsmentioning

confidence: 99%

“…Much phytochemical and biological work has been carried out on essential oils isolated from the genus Jatropha, such as J. curcas , J. ribifolia, J. gossypifolia, and J. mutabilis (Nzikou et al, 2009, Da Silva et al, 2015, Aboaba et al, 2015, Costa et al, 2014). It is worthy to note that this is the first study describing the chemical constituents and biological activities of the essential oil isolated from J. pelargoniifolia roots.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and biological activity of the essential oil from the root of Jatropha pelargoniifolia Courb. native to Saudi Arabia

Aati

El‐Gamal

Kayser

2019

Saudi Pharmaceutical Journal

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The chemical composition of the essential oil from Jatropha pelargoniifolia roots was determined via GC-FID. There were 80 compounds, representing 99.99% of the total oil constituents. Among these, 77.31% were sesquiterpenes, 14.62% were fatty acids, 7.21% were other components (i.e., phenolics, hydrocarbons, etc.), and 0.85% were monoterpenes. The major compounds in the oil were γ-eudesmol (35.31%), 5-guaien-11-ol (14.43%), epi-cedrol (8.19%), oleic acid (5.23%), bulnesol (4.45%), α-linoleic acid (4.20%), 3,4-dimethoxycinnamic acid (3.83%), palmitic acid (2.69%), isolongifolanone (2.68%), eicosane (1.41%), and cedrol (1.14%). Oxygenated sesquiterpenes were found to represent more than 50% percent of the total oil content. Moreover, the essential oil was evaluated for anti-inflammatory, antioxidant, antipyretic, and antinociceptive activities using in vivo and in vitro models. Additionally, the antioxidant potential of the oil was evaluated using various in vitro antioxidant tests, including DPPH•, ABTS•+ and FRAP. At a dose of 240 µl/kg, the oil showed anti-inflammatory (59.12%), antipyretic (37.00 ± 0.11), and antinociceptive (47.58%) activities and showed significant (p < 0.001) effect as compared to a standard drug (phenylbutazone and indomethacin). These findings demonstrated that the essential oil of Jatropha pelargoniifolia root could be used as a natural source for their anti-inflammatory, antinociceptive, antipyretic, and antioxidant effects.

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Chemical Composition and Cytotoxic Activity of the Root Essential Oil fromJatropha ribifolia(Pohl) Baill (Euphorbiaceae)

Cited by 12 publications

References 1 publication

In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)

In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)

Phytochemicals and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Taraxacum officinale (L).

Chemical composition and biological activity of the essential oil from the root of Jatropha pelargoniifolia Courb. native to Saudi Arabia

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